ID   A0A3Q7UCE0_VULVU        Unreviewed;      1384 AA.
AC   A0A3Q7UCE0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   Name=MOV10L1 {ECO:0000313|RefSeq:XP_025875596.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025875596.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025875596.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025875596.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025875596.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC       {ECO:0000256|ARBA:ARBA00005601}.
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DR   RefSeq; XP_025875596.1; XM_026019811.1.
DR   STRING; 9627.ENSVVUP00000034803; -.
DR   KEGG; vvp:112935861; -.
DR   OrthoDB; 170190at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   CDD; cd18078; DEXXQc_Mov10L1; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR049080; MOV-10-like_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR45418; CANCER/TESTIS ANTIGEN 55; 1.
DR   PANTHER; PTHR45418:SF1; CANCER_TESTIS ANTIGEN 55; 1.
DR   Pfam; PF13086; AAA_11; 2.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF21634; MOV-10_beta-barrel; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000313|RefSeq:XP_025875596.1};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Helicase {ECO:0000313|RefSeq:XP_025875596.1};
KW   Hydrolase {ECO:0000313|RefSeq:XP_025875596.1};
KW   Nucleotide-binding {ECO:0000313|RefSeq:XP_025875596.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT   DOMAIN          750..823
FT                   /note="Helicase MOV-10-like beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF21634"
FT   DOMAIN          942..1028
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          1053..1123
FT                   /note="DNA2/NAM7 helicase helicase"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          1134..1346
FT                   /note="DNA2/NAM7 helicase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
SQ   SEQUENCE   1384 AA;  153614 MW;  B7886E9EEFDACED0 CRC64;
     MLRLAAKLLA FFWRRADDTE EEAGPQAPEL AEALAVTRSA GLPPPTSGVE VSTCRVDAAL
     ARRSSGRPEA GDRRRIWGGQ RAKRRLYADS GSGARRRARP WNARFPQPLE LHATAVPAPW
     APRPRPAGDA LPGRGGAHRV DRLPRRAQNV PGPLAGRGDD PLTPRLGSWC GRTVTAAPLL
     GGGRGWPCIA VENVHRDPHA AVDERGVRAR PLAVDSTPAH RAHRLCLRGT CSEGSRDTKL
     KTIQGVVTRY CSDYGMIDDL IYFSNEAVTS KVLLNVGQEV IAVVQEDKVS SGLKAIRVEA
     VSDKWEDDSK THGGGLSDSS PRVLIGCVTS LLEGAGYISQ TTYFSLQSVC EGFKPCKGDW
     VEAEYWIRPG TWSSEAISVK PLRYKHVDRV CISSLCGRNG VIDDSIFFTL DSVKLAEGYV
     PRRHDIVNAV VVESSQSCYI WRALCITPVK KRDPAAFEET TDESNGALLL KNKGDIEVTR
     MTNFGTLKEG GSKNMVIWIE NKGDTPQNLV SCKLAGWDKA KQFRFQMLDK TQMCPVGSPV
     PEKENKNFSD ETANSLESYQ ENPACQASEK EVCPDDRACE EGGDREERKP WKQVTELEPG
     GLIPPGGRAP IVVVCDAKNS GRCKELLLIC FSNFIIGRYL EVNVISGEEL LIAVREPFSW
     KKSKSSPTVT STKTTVVVTT QKRNSRRQLP SFLPQYPIPD RLKKCVEQKI DILTFQPLLA
     ELLNMSNYKE KFSTLLWLEE IHAEIELKEY NMSGVTLKRN GDLLVLEVPG LAESRPSLYA
     GDKLILKTQE YNGHVIEYIG YVIEIHEEDV TLKLNPEFEQ AYNFEPMDVE FTYNRTTSRR
     CHFALEHVIH LGVKVLFPEE IILQSPQVTG NWNLAQDTKN NGHSTIKNRK AMKDQIKHAA
     KERQAGAQDT PGPVALAEES RNLVNDVQTR KAREKGFFNP VLNENQKLAV RRILSGDCRP
     LPYILFGPPG TGKTVTIIEA VLQVYYALLD SRILVCAPSN SAADLVCLRL HESQVLRPGT
     MVRVNATCRF EETVTDAIKP YCKDGEDIWK ASRFRIIITT CSSAGLFYQI GVRVGHFTHV
     FVDEAGQASE PECLIPLGLV SDANSQIVLA GDPMQLGPVI KSRLAMAYGL NVSMLERLMS
     RPAYLRDEDA FGACGAYNPL LVTKLVKNYR SHPALLALPS RLFYHKELEV CADPKVVTSL
     LGWEKLPKKG FPLIFHGVRG SEAREGRSPS WFNAAEAVQV MRYCCLLARG VSSQVSTADI
     GVITPYRKQV EKIKILLRNI DLMDIKVGSV EEFQGQEYLA IIISTVRSNE DRFEDDRYFL
     GFLSNSKRFN VAITRPKALL IVLGNPHVLV KDPCFGALLE YSITNGVYTG CNLPPELQSL
     QNCE
//