ID A0A3Q7UD37_VULVU Unreviewed; 933 AA.
AC A0A3Q7UD37;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator isoform X2 {ECO:0000313|RefSeq:XP_025865365.1};
GN Name=RALGDS {ECO:0000313|RefSeq:XP_025865365.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025865365.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025865365.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025865365.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025865365.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025865365.1; XM_026009580.1.
DR AlphaFoldDB; A0A3Q7UD37; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17209; RA_RalGDS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR015758; RalGDS_RA.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 112..249
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 393..655
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 817..904
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 279..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..322
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 933 AA; 102432 MW; 148C556A256494F0 CRC64;
MVQRMWAEAA GPAGAAEPLF PGSRRSRSVW DAVRLEVGGP DSCPVVLHSF TQLDPDLPRL
ESCTQEIGEE LVNGVIYSIS LRKVQAHHSA NKGQRWLGCE NESALHLYET CKVRTVKAGT
LEKLVEHLVP AFQGSDLSYV TIFLCTYRAF TTTQQVLDLL FKRYGRCDAL TASSRYGCIL
PYSDEDGGPQ DQLKNAISSI LGTWLDQYSE DFCQPPDFPC LKQLVAYVQL NMPGSDLERR
AHLLLAQLEH SELTEAEPEA LSPAPMPVLK TAPELEPALA PPLVPAPELQ SAPAPAPAPA
PAPALERQSA PAPAPELEPA PAPELEPASA LELEPALAPA PELEPALAPA PEPEPALSQT
LELEPAPAPE PPWPSPVAAE NGLNEKPHVL TFPPDLVAEQ FTLMDAELFK KVVPYHCLGS
IWSQRDKKGK EHLAPTVRAT VTQFNSVANC VITTCLGDRS VTARDRARVV EHWIEVAREC
RVLKNFSSLY AILSALQSNS VHRLKKTWEE VSRDSFRVFQ KLSEIFSDEN NYSLSRELLI
KEGTSKFATL EMNPKRAQKR PKETGVIQGT VPYLGTFLTD LVMLDTAMKD YLYGRLINFE
KRRKEFEVIA QIKLLQSACN NYSIAPEEHF GAWFRAMERL SETESYNLSC ELEPPSESAS
NTLKAKKNTA IVKRWSDRQA PSTELSTSGS SHSKSCDQLR CGPYLSSGDL ADALSVHSAG
SSSSDVDEIN MSFVPESPDG QEKKGLGLLL IMPSPQFWES TSQSSPETSG ISSASSSTSS
SSASTTPVSA TRTHKRSVSG VCSYSSSLPL YNQQVGDCCI IRVSLDVDNG NMYKSILVTS
QDKAPAVIRK AMDKHNLDED EPDDYELVQV ISDDRKLKIP DNANVFYAMN STANYDFVLK
KRTFTKGTKV RHGASSTLPR MKQKGLKIAK GIF
//
