ID A0A3Q7UF36_VULVU Unreviewed; 618 AA.
AC A0A3Q7UF36;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Zinc finger protein 461 isoform X1 {ECO:0000313|RefSeq:XP_025866030.1};
GN Name=ZNF461 {ECO:0000313|RefSeq:XP_025866030.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025866030.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025866030.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025866030.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025866030.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025866030.1; XM_026010245.1.
DR AlphaFoldDB; A0A3Q7UF36; -.
DR STRING; 9627.ENSVVUP00000018442; -.
DR KEGG; vvp:112928491; -.
DR OrthoDB; 3120634at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24381; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24381:SF437; ZINC FINGER PROTEIN 461; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 84..155
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 246..273
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 297..327
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 328..355
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 356..383
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 384..411
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 412..439
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 440..467
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 468..495
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 496..523
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 524..551
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 552..579
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 618 AA; 72351 MW; D1CBB511B0870CC7 CRC64;
MPHTTGLLEI SLSAWALSFR TTFPRGHSGA KLLPVGTSAE WSAAEAGEDF TRPAERARLG
ARPRLECKSE FGPAPFLRML KGLVMFKDVA IDVSQEEWEC LNPTQRNLYK DVMLENYSNL
VSLGLSISKP AVISSLEQGK EPWMVEREVT GGWCTDLVSR YEAKKLSPKR DIYETEPSRW
TIMEQFKSHN PEKSIFRDIW ERSSQFETQQ EQEDYFRQFV INHKHLPIFN QHALLTQEFY
NREKIFECKE CRKNFSYHLF FSHHKRTHSK EKRSECKECT GTVNTSYLTK QRIQDSSKCS
EYKECWRAFI HCSQLKQHLR IHNGEKRYEC KECGKAFNYG SELILHQRIH TGEKPYECKE
CGKAFRQRSQ LTQHQRLHTG EKPYECKQCG KAFIRGFQLT EHQRLHTGEK PYECKECGKT
FRHRSHLTIH QRIHTGEKPY ECRECGKTFS YHSSFSHHQK IHSGKKPYEC SECGKAFCDG
LQLTLHRRIH TGEKPYECKE CGKTFRQCSH LKRHQRIHTG EKPHECLICG KAFRLHSHLI
QHQRIHTGEK PYECKECGKA FSYHSSFSHH QRIHSGKKPY ECGKAFKHGL QFNLHKALHT
VKMPVRLPFL SAHTSLTS
//
