ID A0A3Q7UID6_VULVU Unreviewed; 2577 AA.
AC A0A3Q7UID6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Nuclear receptor corepressor 2 isoform X4 {ECO:0000313|RefSeq:XP_025872952.1};
GN Name=NCOR2 {ECO:0000313|RefSeq:XP_025872952.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025872952.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025872952.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025872952.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025872952.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR RefSeq; XP_025872952.1; XM_026017167.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Receptor {ECO:0000313|RefSeq:XP_025872952.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 426..477
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 607..658
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 610..654
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 611..658
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1459..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1526..1627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1786..1889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1983..2055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2087..2131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2168..2187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2238..2303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2311..2330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2450..2563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..818
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..888
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1016
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1473..1489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1603..1627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1786..1809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1810..1835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1836..1889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2169..2187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2316..2330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2488..2502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2577 AA; 280734 MW; 389FC45CE6B50FCD CRC64;
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARPHTDVGLL EYQHHPRDYT SHLSPGSIIQ
PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM EFIESKRPRL ELLPDPLLRP
SPLLAAGQPG ASEDLSKDRS LAGKLEPVSP PSPPHADPEL ELVPPRLSKE ELIQNMDRVD
REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA
AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QRVGQRGSGL
SMSAARSEHE VSEIIDGLSE QENLEKQMRQ LAVIPPMLYD ADQQRIKFIN MNGLMDDPMK
VYKDRQVMNM WSEQEKETFR EKFMQHPKNF GLIASFLERK TVAECVLYYY LTKKNENYKS
LVRRSYRRRG KSQQQQQQQQ QQQQQQQQMP RSSQEEKEEK EKDKEAEKEE EKPDVENDKE
ELNKEKTDDT SGEDNDEKEA VASKGRKTAN SQGRRKGRIT RSMANEANSE EAITPQQSAE
LASMEMNESS RWTEEEMETA KKGLLEHGRN WSAIARMVGS KTVSQCKNFY FNYKKRQNLD
EILQQHKLKM EKERNARRKK KKAPAAASEE AAFPPVVEDE EMEASGASGN EEEMAEEAEA
LHASGNEVPR GECSGPATVN NSSDTESIPS PRTEAAKDTG QNGPKPPPGP GTDVLPPEPP
TPPPEDALVS SEPGPAPETT NPPTPPPAPA SPTAPPPVVP KEEKEEEDAA APLVAEEEEQ
KPPVAQEMAV DMGKTEEPGE ASPAEPIKSE CKEEATEEGP DKGKGGSEPS AEAEATPEGA
LKVEKKEGGG PGGKAPTAKG AGAPQDSDSS ATCSADEVDE PEGGDKNRLL SPRPSLLTST
SDARASASPQ KPLDLKQLKQ RAAAIPPIQV TKVHEPPRED AAPPALPPPQ PLQPENDTPQ
QPSSSPRGKS RSPVPPADKE AEKPVFFPAF APEGQKLPTE APCWTSGLPF PVPPREVIKA
SPHTPDPSAF SYAPPGHPLP LGLHDSVRPV LPRPPTISNP PPLISSTKHP SVLERQMSAI
SQGMSVQLHV PYSEHAKAPV GPITMGLPLA MDPKKLAPFS GVKQEQLSPR GQAGPPESLG
VPTAQETSVL RGTSLGSVPG GSITKGIPST RVPPESPISY RGSITHGTPA DVLYKGTITR
IIGEDSPSRL DRSREDSLPK GHVIYEGKKG HVLSYEGGMS VSQCSKEDGR SSSGPPHETA
APKRTYDMME GRVSRAISSA SIEGLMGRAI PPERHSPHHL KEQHHIRGSI TQGIPRSYVE
AQEDYLRREA KLLKREGTPP PPPPPPRDLA EAYKARPLEA LGPLKLKPAH EGMVATVKEA
GRSIHEIPRE ELRRTPELPL APRPLKEGSI TQGTPLKYDT GTSSAGSKKH DVRSIIGSPG
RTFPPVHPLD VMADARALER ACYEESLKSR PGAAGSSGGS ITRGAPVIVP ELGKPRQSPL
TYEEHGAPFA GHLPRGSPVT TREPTPRLQE GSLSSSKASQ DRKLTSTPRE IAKSPHSAVP
EHHPHPISPY EHLLRGVSGV DLYRGHIPLA FDPTSIPRGI PLDAAAAYYL PRHLAPNPTY
PHLYPPYLIR GYPDTAALEN RQTIINDYIT SQQMHHNAAT AMAQRADMLR GLSPRESSLA
LNYAAGPRGI IDLSQVPHLP VLVPPTPGTP ATAMDRLAYL PTAPQHFSSR LSSSPLSPGG
PTHLTKPSAT SSSERERERD RDRERERERE KSILTSTTTV EHAPIWRPGT EQSSGSSGSG
GGGSSSGGSR PASHSHSHQH SPISPRTQDA IQQRPSVLHN TGMKGIITSV EPSTPTVLRW
ARSTSTSSPV RPAATFPPTT HCPLGGTLDG VYPTLMEPVL PPKEAPRVAR PERPRADAGH
AFLAKPQARV GLEPASPPSK GSEPRPLAPP SSSHSAIART PAKSLAPHHA GPDQPAPPTS
ATDLHREKTQ SKPFSIQELE LRSLGKTTLT AATFIDAIIM RQIAHDKGPR EGGSLANDSP
RDGYHGGSYS PDGVEPISPV SSPSLTHDKG LPKHLEELDK SHLEGDLRHK QPGPGKLSGE
AAHLSHLRPL PESQSSSSPL LQTTPGVKGH QRVVTLAQHI SEVITQDYTR HHPQQLNAPL
PAPLYSFPGA SCPVLDLRRP PSDLYLPPPD HGAPARGSPH SEGGKRSPEP SKMSALGSSE
DAIEPVSPPE GLAEPGHPRS TMYPLLYRDG EQTETSRMGS KSPGNTSQPP AFFSKLTESN
SAMVKSKKQE INKKLNTHNR NEPEYNIGQP GTEIFNMPAI TGAGLMTCRS QAVQEHASTN
MGLEAIIRKA LMGKYDQWEE PPLSANAFNP LNASASLPAA IPITAADGRS EHALTSPGGG
GKAKVSGRPS SRKAKSPAPG LASGDRPPSV SSVHSEGDCN RRTPLTNRVW EDRPSSAGST
PFPYNPLIMR LQAGVMASPP PPGLPAGSGP LAGPHHAWDE EPKPLLCSQY ETLSDSE
//
