ID A0A3Q7UJ08_VULVU Unreviewed; 1067 AA.
AC A0A3Q7UJ08;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 {ECO:0000313|RefSeq:XP_025867335.1};
GN Name=NFATC3 {ECO:0000313|RefSeq:XP_025867335.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025867335.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025867335.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025867335.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025867335.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025867335.1; XM_026011550.1.
DR AlphaFoldDB; A0A3Q7UJ08; -.
DR Ensembl; ENSVVUT00000023092; ENSVVUP00000017501; ENSVVUG00000012905.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF6; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 415..596
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 17..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 115315 MW; 7EDD6FEB220EC7E9 CRC64;
MTTANCGAHD ELDFKLVFGE DGAPAPPPSG SRPADLEPDD CASIYIFNVD PPPSTLNSPL
CLPHHGLPSH SSVLSSSFQL QGHKNYEGTC EIPESKYSPL GGPKPFECPS IQITSISPNC
HQEIDAHEDD LHINDPEREY LERPSRDHLY LPLEPSYRES SLSPSPASSI SSRSWFSDAS
SCESLSHIYD DVDSELNEAA ARFTLGSPLT SPGGSPGGCP GEESWHQQYG LGHSLSPRQS
PCHSPRSSVT DENWLSPRPA SGPSSRPTSP CGKRRHSSAE VCYAGSLSPH HSPVPSPGHS
PRGSVTEDTW LNASVQGGSG LGPALFPFQC CVETDIPLKT RKTSEDQAAV LPGKLEFCSD
DQGNLSPSRE TSIDDGLGSQ YPLKKDSSGD QFLSVPSPFT WSKPKPGHTP IFRTSSLPPL
DWPLPTHFGQ CELKIEVQPK THHRAHYETE GSRGAVKAST GGHPVVKLLG YSEKPINLQM
FIGTADDRYL RPHAFYQVHR ITGKTVATAS QEIIIASTKV LEIPLLPENN MSASIDCAGI
LKLRNSDIEL RKGETDIGRK NTRVRLVFRV HIPQPNGKVL SLQTASIPVE CSQRSAQELP
HIEKYSINSC SVNGGHEMIV TGSNFLPESK IIFLEKGQDG RPQWEVEGKI IREKCQGAHI
VLEVPPYHNP AVTAAVQVHF YLCNGKRKKS QSQRFTYTPV LMKQEHKEEV DLSSVPALSV
PHPAQTQRPS SDTGHPHDSV LSTQRSLVCP VQQTYASMVT SCHLPQLQCR DESAGKEQQM
IPSSIMHQPF QVTPTPPVGS SYQPMQTNVY NGPTCLPVNA ASSQEFDPVL FPQDAALPTL
INLGCQPPSS IPFHSSNSGP TGHLLAHTPH SVQTLPHLQS LGYHCSNTGQ RSLSSPGTDQ
VTGQPSPQLQ PITYGPSHSG SATTASPAAS HPLASSPLSG PPSPQLQPMP YQSPSSGTAS
SPSLTTRMHS GQHSTQAQST GQGGLSAPSS LICHNLCDPA SFPPDEATVN IKPEPEEQEP
NFSTIGLQDI TLDDDQFMSD LEHQPSGSAE KWPNHSELSC PAPFWRI
//
