ID A0A3Q7UM67_VULVU Unreviewed; 795 AA.
AC A0A3Q7UM67;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Ras GTPase-activating protein 2 isoform X2 {ECO:0000313|RefSeq:XP_025874292.1};
GN Name=RASA2 {ECO:0000313|RefSeq:XP_025874292.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025874292.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025874292.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025874292.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025874292.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_025874292.1; XM_026018507.1.
DR AlphaFoldDB; A0A3Q7UM67; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd13370; PH_GAP1m_mammal-like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037773; RASA2_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF21; RAS GTPASE-ACTIVATING PROTEIN 2; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR PRINTS; PR00402; TECBTKDOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..80
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 91..231
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 298..492
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 546..651
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 770..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 91229 MW; 012A22ECBFC43876 CRC64;
MRDCFCTINL DQEEVYRTQV VEKSLSPFFS EEFYFEIPRT FQYLSFYVYD KNVLQRDLRI
GKVAIKKEDL CNHSGKETWF SLQPVDSNSE VQGKVHLELK LNELITENGT VCQQLVVHII
ACHGLPLING QSCDPYATVS VVGPSRNDQK KTKVKKKTSN PQFNEIFYFE VTRSSSYTRK
SQFQVEEEDI EKLEIRIDLW NNGNLVQDIF LGEIKVPVNV LRNDSSHQAW YLLQPRDNGN
KSSKTDDLGS LRLNICYTED YVLPSEYYGP LKTLLLKSPD VQPISASAAY ILGEICRDKN
DAVLPLVRLL LHHDKLVPFA TAVAELDLKD TQDANTIFRG NSLATRCLDE MMKIVGGHYL
KVTLKPILDE ICESSKSCEI DPIKLKEGDN VENNKENLRY YVDKLFSTIV KSSMSCPTVM
CDTFYSLRQM ATQRFPNDPH VQYSAVSSFV FLRFFAVAVV SPHTFHLRPH HPDPQTIRTL
TLISKTIQTL GSWGSLSKSK SSFKETFMCE FFKMFQEEGY IIAVKKFLDE ISSTETKESS
GTSEPVHLKE GEMYKRAQGR TRIGKKNFKK RWFCLTSREL TYHKQPEFIE RKDAIYTIPV
KNILAVEKLE ESSFNKKNMF QVIHMEKPLY VQANNCVEAN EWIDVLCRVS RCNQNRLSLY
HPSAYLNGNW LCCLETSESA LGCKPCTAGV PADIQIDIDE DRETERIYSL FTLSLLKLQK
MEEACGTIAV YQGPQKEPDD YSNFVIEDSV TTFKTIQQIK SIIEKLDEPH EKYRKKRSSS
AKYGSEENPI VGKTS
//
