ID A0A3Q7UQ46_VULVU Unreviewed; 2788 AA.
AC A0A3Q7UQ46;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ankyrin-3 isoform X1 {ECO:0000313|RefSeq:XP_025869330.1};
GN Name=ANK3 {ECO:0000313|RefSeq:XP_025869330.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025869330.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025869330.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025869330.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025869330.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_025869330.1; XM_026013545.1.
DR KEGG; vvp:112931058; -.
DR OrthoDB; 5474900at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08803; Death_ank3; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR037971; Ank3_Death.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 22.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 73..105
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 106..138
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 139..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 172..195
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 234..266
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 267..299
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 300..332
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 333..365
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 366..398
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 399..431
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 432..464
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 465..497
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 498..530
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 531..563
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 564..596
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 597..629
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 630..662
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 663..695
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 696..728
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 729..761
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 762..794
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1017..1172
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1174..1321
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 2380..2464
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1554..1575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2142..2191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2212..2246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2335..2357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2525..2565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2636..2675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2717..2755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2147..2164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2165..2181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2219..2236
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2525..2541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2649..2671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2731..2745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2788 AA; 303370 MW; 3690EDCE4B4A3961 CRC64;
MAHAASQLKK NRDLEINAEE ETEKKRKHRK RSRDRKKKSD ANASYLRAAR AGHLEKALDY
IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV DAATKKGNTA LHIASLAGQA
EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE NHLEVVKFLL DNGASQSLAT EDGFTPLAVA
LQQGHDQVVS LLLENDTKGK VRLPALHIAA RKDDTKAAAL LLQNDNNADI ESKSGFTPLH
IAAHYGNINV ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD
GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV QLLLQHNVPV
DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG FTPLHIACKK NRIKVMELLL
KHGASIQAVT ESGLTPIHVA AFMGHVNIVS QLMHHGASPN TTNVRGETAL HMAARSGQAE
VVRYLVQDGA QVEAKAKDDQ TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA
REGHEDVAAF LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT
PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL LEYGADANAV
TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP LHLAAQEDRV NVAEVLVNQG
ANVDAQTKMG YTPLHVGCHY GNIKIVNFLL QHSAKVNART KNGYTPLHQA AQQGHTHIIN
VLLQNNASPN ELTVNGNTAL AIARRLGYIS VVDTLKVVTE ETMTTTTIIE KHKMNVPETM
NEVLDMSDDE VRKANAPEML SDGDYISDVE EGDRCTWYKI PKVQEFTVKS EDAMTGDTDK
YLGPQDLKEL GDDSLPAEGY MGFSLGARSA SPKISLRSFS SDRSYTLNRS SYARDSMMIE
ELLVPSKEQH LTFTREFDSD SLRHYSWAAD TLDNVNLVSS PVHSGYSSPL PQYDSRFLVS
FMVDARGGSM RGSRHHGMRI IIPPRKCTAP TRITCRLVKR HKLANPPPMV EGEGLASRLV
EMGPAGAQFL GPVIVEIPHF GSMRGKEREL IVLRSENGET WKEHQFDSKN EDLTELLNGM
DEELDSPEEL GKKRICRIIT KDFPQYFAVV SRIKQESNQI GPEGGILSST TVPLVQASFP
EGALTKRIRV GLQAQPVPDE IVKKILGNKA TFSPIVTVEP RRRKFHKPIT MSIPVPPPSG
EGGVNGYQGD STPNLRLLCS ITGGTSPAQW EDITGTTPLT FIKDCVSFTT NVSARFWLAD
CHQVLETVGL ATQLYRELIC VPYMAKFVVF AKMNDPVESS LRCFCMTDDK VDKTLEQQEN
FEEVARSKDI EVLEGKPIYV DCYGNLAPLT KGGQQLVFNF YAFKENRLPF SIKIRDTSQE
PCGRLSFLKE PKTTKGLPQT AVCNLNITLP AHKKETESDQ DDEAEKADRR QSFASLALRK
RYSYLTEPGM KTVERSAGAT RSLPTTYSYK PFFSTRPYQS WTTAPITVPG PAKSGFTSLS
SSSSNTPSAS PLKSIWSVST PSPIKSTLGA STTSSVKSIS DVASPIRSFR TISSPIKTVV
SQSPYNIQVS SGTLVRAPTV PEASPLKGLA SNSTFSSRTS PVTTAGSLLE RSSITMTPPA
SPKSNIHMYS SSLPFKSIIT SAAPLISSPL KSVLSPAKSA VDVISSAKVT MASSLSSPVK
QIPGHAEVAL VNGSISPLKY PSSSTLINGC KATATLQEKI STATNSVSSV VNAATDTVEK
VLSTTTAMPF SPLRSYVSPT PSAFQSLRTP PASALYTSLG SSISATTSSV TSSIITVPVY
SVVNVLPEPA LKKLPDSSSL TKSAAALLSP VKTLTTETRP QSHVSRTSSP LKSSLFLAPS
ALKLSTPSSL SSSQEILKDV AEMKEDLMRM TAILQTDVPE EKPFQPELPK EGRIDDEEPF
KIVEKVKEDL VKVSEILKKD VCVDNKGPLK SPKSDKGLSP EDDWIEFSSE EIREARQQAT
VSHSPSLPER VQVKAKAASE KDYNLTKVID YLTNDIGSSS LTNLKYKFED AKKDGEERQK
RILKPAIALQ EHKLKMPPAS MRPSTSEKEL CKMADSFFGT DTILESPDDF SQHDQDKSPL
SDSGFETRSE KTPSAPQSAE STGPKPLFHE VPIPPVITET RTEVVHVIRS YEPSAGDAPP
GQPEEPVSPK PSPTFTELEP KPTASSIKDK VKAFQMKANG EDDDHSRVLS KGMRVKEETH
ITTTTRMVYH SPPGSEGASE RIEETMSVHD IMKAFQSGRD PSKELAGLFE HKSAVPPDVH
KSAAETAAQH AEKDNQMKPK LERVIEVHIE KGPQSPCERT DIRMAIVADH LGLSWTELAR
ELNFSVDEIN QIRVENPNSL ISQSFMLLKK WVTRDGKNAT TDALTSVLTK INRIDIVTLL
EGPIFDYGNI SGTRSFADEN NVFHDPVDGY PSLQVELETP TGLHYTPPTP CQQDDYFSDI
SSIESPLRTP SRLSDGLVPS QGNVEHSADG PPVVTAEDTS LEDSKLEDSM PLTEMPDAVD
VDESQLENVC LSWQNETSSG NLESPAQARR ITGGLLERLD DSPDQCRDSI TSYLKGEPGK
FEANGSHPEV TPETKTKSYF PESQNDVGKQ SAKETLKPKI HASGRVEEPA SSLAVYQKAL
EETSKFVIEE PKPCVPVSMK KMSRTPPADG KPRLNLHEEE GSSGSEQKVK SPGTALTRMT
ACCYKQGEGY KVKTTKKEIR HVEKKSHS
//
