ID   A0A3Q7UUV0_VULVU        Unreviewed;       266 AA.
AC   A0A3Q7UUV0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Patatin-like phospholipase domain-containing protein 4 isoform X1 {ECO:0000313|RefSeq:XP_025871065.1};
GN   Name=PNPLA4 {ECO:0000313|RefSeq:XP_025871065.1};
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025871065.1};
RN   [1]
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JAN-2019) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_025871065.1}
RP   IDENTIFICATION.
RC   STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025871065.1};
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_025871065.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_025871065.1; XM_026015280.1.
DR   AlphaFoldDB; A0A3Q7UUV0; -.
DR   KEGG; vvp:112932354; -.
DR   OrthoDB; 5395310at2759; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050253; F:retinyl-palmitate esterase activity; IEA:InterPro.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07222; Pat_PNPLA4; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR033562; PLPL.
DR   InterPro; IPR033902; PNPLA4.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR12406; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED; 1.
DR   PANTHER; PTHR12406:SF7; PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..189
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   266 AA;  29468 MW;  793B6DD0A22C4068 CRC64;
     MEVPGACIAR MKHINLSFAA CGFLGIYHLG AASALCRHGK KLLKDVKAFA GASAGSLVAS
     VLLTAPEKLE ECNEFTYKFA EEIRRQSFGA VTPGYDFMAR LRSGMELILP PNAHELAHNR
     LHVSITNTKT RENYLVSSFS SREDLIKVTQ VLLASSFVPI YAGLKPVEYQ GQKWVDGGLT
     NSLPILPVGR TVTISPFSGR LDISPQDKGQ LDLYINITNQ DIMLSVANLV RLNQALFPPS
     KRKMESLYQD GFDDAIKFLL KENWFE
//