ID A0A3Q7UZF8_VULVU Unreviewed; 2575 AA.
AC A0A3Q7UZF8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Nuclear receptor corepressor 2 isoform X6 {ECO:0000313|RefSeq:XP_025872955.1};
GN Name=NCOR2 {ECO:0000313|RefSeq:XP_025872955.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025872955.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025872955.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025872955.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025872955.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR RefSeq; XP_025872955.1; XM_026017170.1.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Receptor {ECO:0000313|RefSeq:XP_025872955.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 427..478
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 608..659
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 611..655
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 612..659
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1181..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1460..1492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1527..1628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1787..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1908..1940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1981..2053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2085..2129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2166..2185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2236..2331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2448..2561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..819
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1017
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1474..1490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1604..1628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1787..1810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1811..1836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1837..1890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1908..1932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2167..2185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2314..2331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2486..2500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2575 AA; 280407 MW; 9C1155DAB48DEA45 CRC64;
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARPHTDVGLL EYQHHPRDYT SHLSPGSIIQ
PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM EFIESKRPRL ELLPDPLLRP
SPLLAAGQPG ASEDLSKDRS LAGKLEPVSP PSPPHADPEL ELVPPRLSKE ELIQNMDRVD
REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA
AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG
LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM
KVYKDRQVMN MWSEQEKETF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK
SLVRRSYRRR GKSQQQQQQQ QQQQQQQQQM PRSSQEEKEE KEKDKEAEKE EEKPDVENDK
EELNKEKTDD TSGEDNDEKE AVASKGRKTA NSQGRRKGRI TRSMANEANS EEAITPQQSA
ELASMEMNES SRWTEEEMET AKKGLLEHGR NWSAIARMVG SKTVSQCKNF YFNYKKRQNL
DEILQQHKLK MEKERNARRK KKKAPAAASE EAAFPPVVED EEMEASGASG NEEEMAEEAE
ALHASGNEVP RGECSGPATV NNSSDTESIP SPRTEAAKDT GQNGPKPPPG PGTDVLPPEP
PTPPPEDALV SSEPGPAPET TNPPTPPPAP ASPTAPPPVV PKEEKEEEDA AAPLVAEEEE
QKPPVAQEMA VDMGKTEEPG EASPAEPIKS ECKEEATEEG PDKGKGGSEP SAEAEATPEG
ALKVEKKEGG GPGGKAPTAK GAGAPQDSDS SATCSADEVD EPEGGDKNRL LSPRPSLLTS
TSDARASASP QKPLDLKQLK QRAAAIPPIQ VTKVHEPPRE DAAPPALPPP QPLQPENDTP
QQPSSSPRGK SRSPVPPADK EAEKPVFFPA FAPEGQKLPT EAPCWTSGLP FPVPPREVIK
ASPHTPDPSA FSYAPPGHPL PLGLHDSVRP VLPRPPTISN PPPLISSTKH PSVLERQMSA
ISQGMSVQLH VPYSEHAKAP VGPITMGLPL AMDPKKLAPF SGVKQEQLSP RGQAGPPESL
GVPTAQETSV LRGTSLGSVP GGSITKGIPS TRVPPESPIS YRGSITHGTP ADVLYKGTIT
RIIGEDSPSR LDRSREDSLP KGHVIYEGKK GHVLSYEGGM SVSQCSKEDG RSSSGPPHET
AAPKRTYDMM EGRVSRAISS ASIEGLMGRA IPPERHSPHH LKEQHHIRGS ITQGIPRSYV
EAQEDYLRRE AKLLKREGTP PPPPPPPRDL AEAYKARPLE ALGPLKLKPA HEGMVATVKE
AGRSIHEIPR EELRRTPELP LAPRPLKEGS ITQGTPLKYD TGTSSAGSKK HDVRSIIGSP
GRTFPPVHPL DVMADARALE RACYEESLKS RPGAAGSSGG SITRGAPVIV PELGKPRQSP
LTYEEHGAPF AGHLPRGSPV TTREPTPRLQ EGSLSSSKAS QDRKLTSTPR EIAKSPHSAV
PEHHPHPISP YEHLLRGVSG VDLYRGHIPL AFDPTSIPRG IPLDAAAAYY LPRHLAPNPT
YPHLYPPYLI RGYPDTAALE NRQTIINDYI TSQQMHHNAA TAMAQRADML RGLSPRESSL
ALNYAAGPRG IIDLSQVPHL PVLVPPTPGT PATAMDRLAY LPTAPQHFSS RLSSSPLSPG
GPTHLTKPSA TSSSERERER DRDRERERER EKSILTSTTT VEHAPIWRPG TEQSSGSSGS
GGGGSSSGGS RPASHSHSHQ HSPISPRTQD AIQQRPSVLH NTGMKGIITS VEPSTPTVLR
STSTSSPVRP AATFPPTTHC PLGGTLDGVY PTLMEPVLPP KEAPRVARPE RPRADAGHAF
LAKPQARVGL EPASPPSKGS EPRPLAPPSS SHSAIARTPA KSLAPHHAGP DQPAPPTSAT
DLHREKTQSK PFSIQELELR SLGKTTLTAA TFIDAIIMRQ IAHDKGPREG GSLANDSPRD
GYHGGSYSPD GVEPISPVSS PSLTHDKGLP KHLEELDKSH LEGDLRHKQP GPGKLSGEAA
HLSHLRPLPE SQSSSSPLLQ TTPGVKGHQR VVTLAQHISE VITQDYTRHH PQQLNAPLPA
PLYSFPGASC PVLDLRRPPS DLYLPPPDHG APARGSPHSE GGKRSPEPSK MSALGSSEDA
IEPVSPPEGL AEPGHPRSTM YPLLYRDGEQ TETSRMGSKS PGNTSQPPAF FSKLTESNSA
MVKSKKQEIN KKLNTHNRNE PEYNIGQPGT EIFNMPAITG AGLMTCRSQA VQEHASTNMG
LEAIIRKALM GKYDQWEEPP LSANAFNPLN ASASLPAAIP ITAADGRSEH ALTSPGGGGK
AKVSGRPSSR KAKSPAPGLA SGDRPPSVSS VHSEGDCNRR TPLTNRVWED RPSSAGSTPF
PYNPLIMRLQ AGVMASPPPP GLPAGSGPLA GPHHAWDEEP KPLLCSQYET LSDSE
//
