ID A0A3Q7V007_VULVU Unreviewed; 811 AA.
AC A0A3Q7V007;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=PH and SEC7 domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_025873125.1};
GN Name=PSD2 {ECO:0000313|RefSeq:XP_025873125.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025873125.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025873125.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025873125.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025873125.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR RefSeq; XP_025873125.1; XM_026017340.1.
DR AlphaFoldDB; A0A3Q7V007; -.
DR STRING; 9627.ENSVVUP00000013676; -.
DR KEGG; vvp:112933991; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF329; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 297..500
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 550..663
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 34..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 691..718
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 63..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..306
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 89271 MW; 04ED0880850C32DC CRC64;
MACRDSRGQV EKILRLDQVV GSPRNIQHRE EAVAAMEEDK LSSGEGGTAW DPSLEPEEEP
GVQNGMTHSQ DLNSSYNSPG HEMRGTLVDT EESMQGPDMA LRGLSLGLSF TNGPVLGPDS
NTLEDSAESR AWRVGGLAEG DNAPRNLCLD TEDPQLGLGG PGEPDVRDGF SATFEKIVES
ELLRGTQYSS LDSLDVLSLT DESDSCVSFE APLTPLIQQR ARDSPEPGAG LGTGEMGPEG
DMGAAGGDGE LGSPLRRSIS SSRSENVLSR LSLTAVPNGF HEDGPQGPGG DEEEEEEEEE
EEDTDKLLNS ASDPSLKDGF SDSDSELSSS EGLEPGSTDP LANGCQGVSE AARRLARRLY
HLEGFQRCDV ARQLGKNNEF SRLVAGEYLS FFDFSGLTLD RALRTFLKAF PLMGETQERE
RVLTHFSRRY CQCNPEDSTS EDGIHTLTCA LMLLNTDLHG HNIGKKMSCQ QFIANLDQLN
DGQDFAKDLL KTLYNSIKNE KLEWAIDEDE LRKSLSELVD DKFGTGTKKV TRILDGGNPF
LDVPQALSAT TYKHGVLTRK THADMDGKRT PRGRRGWKKF YAVLKGTILY LQKDEYRPDK
ALSEGDLKNA IRVHHALATR ASDYSKKSNV LKLKTADWRV FLFQAPSKEE MLSWILRINL
VAAIFSAPSF PAAVSSMKKF CRPLLPSCTT RLCQEEQLRS HENKLRQVTS ELAEHKCHPI
ERGVKSKEAE ENRLKEHYLT FEKSRYETYI HLLAVKIKVG SDDLERIEAR LATLEGDDPS
LRKTHSSPAL SQGHGTVTGS KATKDTTGPD T
//