ID A0A3Q7V3M1_VULVU Unreviewed; 544 AA.
AC A0A3Q7V3M1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=ETS-related transcription factor Elf-2 isoform X6 {ECO:0000313|RefSeq:XP_025874255.1};
GN Name=ELF2 {ECO:0000313|RefSeq:XP_025874255.1};
OS Vulpes vulpes (Red fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX NCBI_TaxID=9627 {ECO:0000313|Proteomes:UP000286640, ECO:0000313|RefSeq:XP_025874255.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_025874255.1}
RP IDENTIFICATION.
RC STRAIN=TameXAggressive cross {ECO:0000313|RefSeq:XP_025874255.1};
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_025874255.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_025874255.1; XM_026018470.1.
DR AlphaFoldDB; A0A3Q7V3M1; -.
DR Proteomes; UP000286640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR022084; TF_Elf_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF10; ETS-RELATED TRANSCRIPTION FACTOR ELF-2; 1.
DR Pfam; PF12310; Elf-1_N; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000286640}.
FT DOMAIN 160..242
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 58740 MW; 6064BCDEA3329242 CRC64;
MMQDVAEEQE VETENVETVE ASVHSSNAHC TDKTIEAAEA LLHMESPTCL RDSRSPVEVF
VPPCVSTPEF IHAAMRPDVI TETVVEVSTE ESEPMDTSPI PTSPDSHEPM KKKKAQRASQ
IIRSSAIVGR KPKTQQSPIS NGSPELGIKK KPREGKGNTT YLWEFLLDLL QDKNTCPRYI
KWTQREKGIF KLVDSKAVSK LWGKHKNKPD MNYETMGRAL RYYYQRGILA KVEGQRLVYQ
FKDMPKNIVV IDDDKSETCN EDLAAATDEK SLERVSLSAE SLLKAASVRG GKNSSLNCSR
AEKGVARVVN ITSPGHDTPS RCPTTTASVS ATTAPRTVRV AMQVPVVMTS LGQKISTVAV
QSVNAGAPLI TSTSPTTATS PKVVIQTIPT VMPASSENGD KITMQPAKII TIPATQLAQC
QLQTKSNLTG SGSINIVGTP LAVRALTPVS IAHGTPVMRL SVPTQQASGQ TPPRVISAVI
KGPEVKSEAV AKKQEHDVKT LQLVQEEKPA DGNKTVTHVV VVSAPSAIAL PVTMKTEGLV
TCEK
//
