ID A0A3Q7WT62_URSAR Unreviewed; 3110 AA.
AC A0A3Q7WT62;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 10-FEB-2021, entry version 10.
DE SubName: Full=centromere protein F {ECO:0000313|RefSeq:XP_026364928.1};
GN Name=CENPF {ECO:0000313|RefSeq:XP_026364928.1};
OS Ursus arctos horribilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=116960 {ECO:0000313|Proteomes:UP000286642, ECO:0000313|RefSeq:XP_026364928.1};
RN [1]
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JAN-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_026364928.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_026364928.1};
RG RefSeq;
RL Submitted (OCT-2020) to UniProtKB.
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DR RefSeq; XP_026364928.1; XM_026509143.1.
DR KEGG; uah:113262693; -.
DR Proteomes; UP000286642; Genome assembly.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000286642}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1892..2032
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2128..2267
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2310..2449
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2966..3009
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 245..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2901..3110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 273..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 386..413
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 418..438
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 463..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 509..615
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..643
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 651..671
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 686..713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 725..759
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 839..866
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 899..947
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 955..996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1029..1077
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1118..1159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1202..1243
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1293..1320
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1397..1417
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1550..1613
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1789..1851
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1889..1909
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1931..1958
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1966..1996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2013..2082
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2139..2201
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2209..2275
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2293..2313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2321..2457
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2500..2600
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2608..2674
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2679..2713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2715..2735
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2750..2822
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2830..2860
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2868..2888
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 246..273
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2912..2928
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2951..2980
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3020..3076
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3110 AA; 357184 MW; CBD6AC0B4A925F12 CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
CKSELERSQQ AAQAADVSVY SSSTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKASQAIPQS TMNHRDIARH QASSSVFSWQ QEKTPTRLSL NALKTPIRRD
FSASHFSGEQ EVTPSRSTLQ TGKRDANSSF CDNSSNSHLL DQLKAQNQEL RNKISDLELH
LQGQEKEMKG QANKCQELQL QLEKAKAELI EKEKALNKSR DELVRSTAQY DQASAKCTAL
EQKLKRLSED LSCQRQNAES ARCSLEQKLK EKEKEFQEEL SRQQRTFQAL DQESTQMKAR
LTQELQQAKN THNILQADLD KVTSGKYQLE KTLEEFKQKF CRAEQALQAS QVKENELRRS
SEEAKKEYSL LKGQSEQRAR EVCHLEEELR KAKQSLSQSQ NVAEEIRAKN ASQETMLRDL
QEKVNQQENS LTLDKLKLAL VDLEKQRDCS QDLLKKREHH IEQLNDKLSK MEKESEALLI
ALELKKKEYE ELKEEKTLFA RWKSENEQLL SQLESEKGSL QSKINHLETC LKTQQIKSHE
YNEKVRTLEM ESENLHVEIR NLHNMIDSKT VEVETQKQAY ADLQQKAEFS DQKHKKETEN
MCLKISELTG QVEDLEHKLQ LLSSEVIDKD QRYQDLQAEY ESLGDLLKSK DSSLVTNEAH
HRSLLAFEQQ SAMNNSFVNI IGEQGSTPSE RSKCHLEALP SPKSSAILQN RVLSLEFSLE
SQKQMNSDLQ KQCEELVQIR GEIEENLIKA EQMHQSFVAE TSQRISKLQE DTSVHQNAFA
ETLVALENKE REIQLLNEKL ETEQAEIQEL KKSNHLLQES LKALQLLSET LSSEKKEMSS
TISLNRKEIE NLTQENETLK EINATLNQEK INLLQKSESF SNCIDERDKS ISELSNQYKQ
ERLILQQRCE ETGRAFEDLS EKYQAAQEKN SQLECLLNEC TSACENRQKE LDHLKETFAR
EQEVFVTKLA LAEETNQNLV LELGAVQQDL RSEIADIQNN SKSEADGLKQ EIMTLKEEHS
KMQRELNALM QENEHLMMLM ETKQEHQILE SEAISDSVER ESEINKCHVQ LPMDLEVKDP
SLDCYNAQLM QLEAKRRNRE LKLQESEKDK ERLQHELQTI GIELETGNLQ RDSQSQELSG
PKDCDIGTEE KYISVLHELS ASQNDNALLQ CSLQTAMSKL SELEKMCEML QVEKLELMSE
LNDSRSECIT ATSKMAEEME KLVNEVKIPN DENDLLQGEL VKDMVEGESD ERQNEQKRAS
SNPLDDSNCY EHLTLSNKEV QMHFAELQEK FSSLQSEHKV LYDQHRQVSS KMSELQSYVD
TLKAENSILS TSLRNFQGDL VKEEMLGPKE GHFLSLSFSC VTDSPSLTRL GESSFCKDLL
DQTGETSLLN NLEGTISANQ SNIEEGSCCS PGEEKNLTRK EILSAPARSV EELETLCQMY
LESLKKLEDK IESQEIMKNK EIKELEQLLS SEREELDCLR KQYLSENEQW QQKLTSVTME
MESKLAAEKK QTEHLSFELE VARLQLQGLD LSSRSLLGPD IEEALQVGNN SCDVKESEEH
TLETKERTPK HDIHQICEEG VQQDLNLEME KVTKTSPVRF TEEWSREQSL ETPAEDKTEG
CLERISDLSF SGPNALVPMD FLETQVTIQN LQLQVKESSN ENLRLLHIIE ERDKKVESLL
NEIKELDSKL HVQKAQITAK MEACIELEKM VEELKKEKSN LSERLESFSC DKQKLHQRTE
SLEGLSSSLE ICADKLSHAI IEDSVAKVND NWRERFLDVE NELKRIQSEK GSIEHHALSL
EADLETVQTE KLYLEKDNEN QQNVIIRLEE ELSVVTSERN RLHGELDTLS KENKELDLMS
EKMKQKIREL ESHQGEGHID VAGAEVRDQT QLIETLSSDV TKLLEENTHL QEQLQNVEKD
SQALSLVKSE LEIQIEQLSR EKESLARESE SLQTRLHESE HEKLTVTKAL EGALLEKGEV
AVRLSSTQEE VYQLRQGIEK LRVRIEADDK KQLHVLEKLR VSERKADSLQ DKVENLEREL
QMSEENQELV ILDAESSKAE VEALKTQMEL MTKSLGDLEL DLGTIRFEKE NLVKQLQEKQ
GQVSELDTLL SSLKGRLEEE EQEKIEMREE SKAALEMLQT QLKELNEEVI ALCHDQEIQK
VEEQSLDPSV QEIHQLRNSI EKLKVRLEAD EKEQLQVLGK LTESEHHVDL LKDRVENLER
ELERSRENQE RVILEAENSK AEVGTLKAKI EEMAQTLRDL ELDLVHIRSE KENVIKELQK
EQGRVSELEI LNSSFENLLQ EKEQEKVQMK EESKIAVETL QTQLKELNEK VAALCHDQDT
WKAQAQSLRS QVDALGYEKA QLLQGLDEVK NNYLNVQSSA NGLLQQVEDG KQKLEKKDEE
ISILKNQVQD REQLASKLSQ VEGEQQLWKK QKVELENLMV ELEEKIRVLQ SKNDTLQDTL
EALQDSHRDL EKELELTKME NVSFVEKVNA MTGKETELQR EMREMAQKTT ELKEEYFGEK
NRLTEELNIM SQEIKSSKGQ LKELMLENSE LKKNLDYIHK DQMEKEEKVQ EERAEYQLQL
QEAEKKHQAL LLDTNKQYEM EIQTYREKLS SQEECLSLQK AEVDLLKSSK EELNNSLKAT
TQILEELKKT KADNVKYTNQ LKKENERAQG KIKLLIKSCK QLEEEKEMLQ KELSHLEAAQ
EKQKTGTVVD SNVEDLMAEI KELKETLEEK NKEADEYLDK YCSLLISHEK LEKAKEMLET
QVARLSSQSK LNLQHSPLLN SVVPEASPAP SATEKKLSSS QSKASGKRQR STGIREDGGG
TAPSTPETFS KKSRKAVKSG IHPAEDARDT EFEPEGLPEV VKKGFADIPT GKASPYVLRR
TTMPTRTSPR LAAQKLAPSP LSLNKENHAE TSQPTAGGSR SQKVKVAQQS PADSSAPFRE
PTTRSLSVSN LPERSPANSP REGLRAKRGR LAPSPEAVPE SKSSENCRVQ
//
