ID A0A3Q7Y9B6_CICAR Unreviewed; 2123 AA.
AC A0A3Q7Y9B6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN Name=LOC105851746 {ECO:0000313|RefSeq:XP_027188657.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_027188657.1};
RN [1] {ECO:0000313|RefSeq:XP_027188657.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_027188657.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_027188657.1; XM_027332856.1.
DR OrthoDB; 625762at2759; -.
DR Proteomes; UP000087171; Chromosome Ca3.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171}.
FT DOMAIN 1825..1986
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 33..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2123 AA; 242725 MW; 0EAEB65FE75DF0BF CRC64;
MEELEQNQEV MRMDVNQLKD KVDQILEAIQ ALSRKGNIDE NPPAVNEEQQ TTPSHPPGFT
PTIQQPRTRT IQFPMYGLPP GYTPPLVVNP MENNPNHLNP QNTQPSENIP YIAPQVPHFD
TNGKWHQPHI GDDTQSKEKF HVLEERIKAI EGYNVYGLEA FDMCLVPDVT IPAKFKVPDF
EKYKGNTCPK NHLTMYCRKM ASHAHNDKLL IHFFQDSLSG ASLSWYMHLE RNQIRSWKDL
ADAFLKQYRY NVDMAPDRMQ LQNSLKKDNE AFKEYAQRWR EMASQVEPPL SEREMVGMFM
DTLQSPFYDK MIGSMSSNFS DLVMIGERIE SGMRSGKIVC AATSVKRPQT TFTKKKEGDT
NAVMVNPRIS YFPPINSYRP PIFQPPIPQN PYIPYPYGAV GHSIEDCQAL KSKVQELINA
KWLTFKEDNP NIGSNPLPGH GNASVNFIED GIDQHAVDGH VFTMGSCVEN NISFPKPLEI
LYKKENLKST HNKPNAIIVQ TPIPFPYGNT KAVPWKYEVT SHLADHQPSD DCEPKGTEVT
NISGIGGMTR SGRVYTPEQL RKKEVNGEKG KEDMYHTIKG QEISKKTVSE EEASEFLKFV
KQSEYKVVDQ LNQTPSKISV LSLLLNSEAH RRALMKVLNE AHVTHDITVD QFDGVVGNIT
ASSCLSFSDN ELPAEGTEHN KALHISMRCH DHILARVLVD NGSSLNVMPK SHCQSYLLIS
KLFVEGACLK RSALVVKAFD GSRRQVVGEI DLPIQIGPHI FGITFQTMDM DIKPAYSCLL
GRPWIHAAGA VTSTLHQKLK FIVNNKLVII SGEEDMIVSH LSSTSYIENT EEAIETSFQA
LEIANAVFRG EEYRLKEPKL STTSLKFTKS MLEGGVCXLG KLIEIPEKNN RYGLGYVPTQ
ADKEKVAKGK RENWTLNSQK IPIYDIRQAF QSAGIIYAHQ VAVTEEDHVD GDTLKLVYPC
PPNISLNNWK ILEFPVFVNS FENEYVENSS AITISCNFGH LINHADEDCE DDCELPSELK
ALIEQEAKII QPYQEPIEVI NLGTEHDKKE VKVGMSMKEG EXEKLVKLLI DYVDVYTWSY
QDMPRLDTNI VEHKLPLKPE YTPIKQKLRR MRPDMSLKIR EEVKKQFDAG FLAVAKYPQW
VANRMCVDYR DLNKASHKDD FPLPHIDVLV DSTAQYSLFS FMDSFSGYNQ IKMAPEDMEK
TTFITQWETF CYKVIPFGLK NAGATYQRAM VTLFHDMMHK EIEVYVDDMI AKSQTEEDHV
VNLQKLFERL RKFKLRLNPA KCTFGVRSGK LLGFIVSQKG IEVDPDKVRA IQEMPAPRTE
KEVRGFLGRL NYIARFISHL TATCEPIFKL LRKDQKVEWN ENCQKAFEKI KQYLSKPPIL
VPPVPGKPLI MYLTVLDESM GCVLGQHDES GRKEHAIYYL SKKFTSCETR YSLLERTCCA
LAWAARRLRQ YMLCHTTWLV SKMDPIKYIF EKPALTGRIA RWQMLLSEYD LVYVTQKSIK
GSALAEYLAH QPVEDYQSMQ CEFPDEDIMN LVEEIESSDK EKWRLVFDGA SNALGHGIGA
ILISPENQFT PFTARLCFDC TKNIAEYEAC VMGIKAAIES NVKFLEVYGD SLLVIHQTKG
DWETRDSKLI PYHTHIKELT EQFEKITFHH IPREENQLAD ALATLSSMFK ITTNQDVPVI
KIQQRDKPAY CLSIEEELDG KPWFYDIKSY VKNKEYPLGI SENDKRVLRR LSMNFFLNGD
VLYKRNHDMV LLRCVDKAEA GKIIQEVHEG SFGTHANGHT MARKILRAGY YWLTMESDCF
SHVKKCHKCQ IYADKIHVPP TSLNVLTSPW PFSMWGMDVI GLIEPKASNG HRFILVAIDY
FTKWVEAASY ANVTRSVVVR FIKRELICRY GLPNKIITDN ATNLNNKMMK ELCDNFKIQH
HNSSPYRPKM NGAVEAANNN IKKIIQKMVE AYKDWHEMLP FALHGYRTFV RTSTGSTPFS
LVYGMEAVLP IEVEIPSIKV LMETKLEEAE WVQSRYDQLN LIEEKRMIAL CHGQLYQKRL
KKAYEKKIRP REFXEGELFQ EGELVLKKIL PIKKDSRGKW TPNYEGPYVV KKAFSAGALI
LAEMDGDELP LPVNSDAVKK YYA
//
