GenomeNet

Database: UniProt
Entry: A0A3Q8SAL8_9BACL
LinkDB: A0A3Q8SAL8_9BACL
Original site: A0A3Q8SAL8_9BACL 
ID   A0A3Q8SAL8_9BACL        Unreviewed;       305 AA.
AC   A0A3Q8SAL8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=MBL fold metallo-hydrolase {ECO:0000313|EMBL:AZK46306.1};
GN   ORFNames=EIM92_09055 {ECO:0000313|EMBL:AZK46306.1};
OS   Paenibacillus lentus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1338368 {ECO:0000313|EMBL:AZK46306.1, ECO:0000313|Proteomes:UP000273145};
RN   [1] {ECO:0000313|EMBL:AZK46306.1, ECO:0000313|Proteomes:UP000273145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25539 {ECO:0000313|EMBL:AZK46306.1,
RC   ECO:0000313|Proteomes:UP000273145};
RA   Kook J.-K., Park S.-N., Lim Y.K.;
RT   "Genome sequencing of Paenibacillus lentus DSM25539(T).";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Counteracts the endogenous Pycsar antiviral defense system.
CC       Phosphodiesterase that enables metal-dependent hydrolysis of host
CC       cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
CC       {ECO:0000256|ARBA:ARBA00034301}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic CMP + H2O = CMP + H(+); Xref=Rhea:RHEA:72675,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58003,
CC         ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00034221};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72676;
CC         Evidence={ECO:0000256|ARBA:ARBA00034221};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic UMP + H2O = H(+) + UMP; Xref=Rhea:RHEA:70575,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57865,
CC         ChEBI:CHEBI:184387; Evidence={ECO:0000256|ARBA:ARBA00034227};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70576;
CC         Evidence={ECO:0000256|ARBA:ARBA00034227};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP034248; AZK46306.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3Q8SAL8; -.
DR   KEGG; plen:EIM92_09055; -.
DR   OrthoDB; 9761531at2; -.
DR   Proteomes; UP000273145; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:AZK46306.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000273145}.
FT   DOMAIN          21..95
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF00753"
FT   COILED          149..176
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   305 AA;  34403 MW;  D90FC47397B8A307 CRC64;
     MTYVIDFLNV GFGEAAVVRI EDGQRSYCLV VDAGDADCHK HARRCSLEQY VREYGINKID
     ALILTHFHKD HIGGVREVLG HVPIGEILLH VPLPSHLLNS RLSDHSTPIL ASLSLYIAIL
     KQAKELGIPV RQISEPFALS ELAVEFRLLT PNQAKLQQLQ AELESLEVEA LNRQQERLTR
     IDRMLNDTAL AVLIRYKHNP AALLTSDVGL DFWSPYESEI KDVYLLQAPH HGDAQRISQA
     LLHTVSPKVV VVSADDEGTY QLPHPEFEVA VTEHSAARIY YTEEAGSRHR IIRMDLNERT
     IHLIK
//
DBGET integrated database retrieval system