ID A0A3Q8VDV0_9ACTN Unreviewed; 566 AA.
AC A0A3Q8VDV0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Bifunctional 3'-5' exonuclease/DNA polymerase {ECO:0000313|EMBL:AZM60889.1};
GN ORFNames=DLM49_16180 {ECO:0000313|EMBL:AZM60889.1};
OS Streptomyces sp. WAC 01438.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2203204 {ECO:0000313|EMBL:AZM60889.1, ECO:0000313|Proteomes:UP000271045};
RN [1] {ECO:0000313|EMBL:AZM60889.1, ECO:0000313|Proteomes:UP000271045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAC 01438 {ECO:0000313|EMBL:AZM60889.1,
RC ECO:0000313|Proteomes:UP000271045};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; CP029601; AZM60889.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3Q8VDV0; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000271045; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:AZM60889.1};
KW Hydrolase {ECO:0000313|EMBL:AZM60889.1};
KW Nuclease {ECO:0000313|EMBL:AZM60889.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000271045}.
FT DOMAIN 311..525
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 102..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 61273 MW; 70B454F40D0E32FB CRC64;
MADRWALAPA EEGGVDVAPL GPDGLPAGPV RREADLAEAV RSRPGVARWV WRSTAEVYPR
LLATGVRVER GYDIEAAETL LLGHEGRYGE PRSAAAALAR LRGSPVPPDP PQRHAEPGAQ
SPLFEPSGTP LPLADLLAVY AEQQRRTDAT AHPDRMRLLT AAESAGMLVA AEMNRAGLPW
RADVHRAVLH DLLGERYAGG GEPRRLAELA DEVSAAFGRR VRPDLPADVV KAFAQAGIKV
SSTRRWELET VEHPAVKPLI EYKKLYRIWV AHGWSWLQDW VRDGRFRPEF LAGGTVTGRW
VTNGGGALQI PKVIRRAAVA DPGWRLVVAD ADQMEPRVLA AISRDPGLME VAGRETDLYQ
SVSERAFSGD RAQAKLAVLG AVYGQTSGDG LKNLAALRRR FPRAVAYVDE AARAGEEGRL
VRTWLGRTCP PAARATDDAA EEAGIPLASP AEDDRSADAR PWVPGYASTD ARARGRFARN
FVVQGSAADW ALLLLAALRQ TLAGMAAELV FFQHDEVIVH CPEEEAATVA EAIRQAADLA
GRLTFGETPV RFPFTTAVVE CYADAK
//
