ID A0A3Q8VHU2_9ACTN Unreviewed; 4753 AA.
AC A0A3Q8VHU2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AZM63655.1};
GN ORFNames=DLM49_32430 {ECO:0000313|EMBL:AZM63655.1};
OS Streptomyces sp. WAC 01438.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2203204 {ECO:0000313|EMBL:AZM63655.1, ECO:0000313|Proteomes:UP000271045};
RN [1] {ECO:0000313|EMBL:AZM63655.1, ECO:0000313|Proteomes:UP000271045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAC 01438 {ECO:0000313|EMBL:AZM63655.1,
RC ECO:0000313|Proteomes:UP000271045};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP029601; AZM63655.1; -; Genomic_DNA.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000271045; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 2.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 6.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000271045};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..456
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1444..1519
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1538..1961
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2902..2977
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2996..3420
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4604..4679
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4753 AA; 498783 MW; 3FF16F9660B89BE7 CRC64;
MTDDKKLLDY LRRATAELGQ TKEALREARR ARHEPIAIVG MDCRYPGGVA SPEDLWNLVA
EGTDAITEWP ANRGWDLEGR YDPDPERTGT SYTRNGGFLH DADLFDAGFF GISPREALSM
DPQQRLLLET AWTAVERAGL DPHTLRGTRT GVYIGAIGNG YGDRSRDVPE LQALLDTGTA
DSVVSGRVSY VLGLEGPAVS VNTACSSSLV AIHLAVQALR TGEATMALAG GVTVMATLDA
YIAFSRQRGL SPDGRCKAFA DAADGTGWSE GVGVLVLERL SDARRNGHRI LGVIRGSALN
QDGASNGLTA PNGPSQQRVI KDALANAQLS PGDIDAVEAH GTGTRLGDPI EAQALLATYG
RHRERPLWLG SLKSNLGHSA AAAGVGGVIK MVMAMRHGVL PKTLHVDTPS RAVDWSAGRV
ELLTEAREWE EAGAPRRAGV SAFGVSGTNA HVILEQAPVG EPVESAGVSS GVVPWVVSGR
SVGALRAQAG RLVPLVGEDR AAVGAALWGR SVFEHRAVVV GGSAEEFAAG LRAVAEGEAL
TGGVAGPVGR TVFVFPGQGS QWSGMAVELL GSSAVFAARF GECERALEPF VDWSLAEVVR
SGVYDRVDVV QPVLWAVMVS LAAVWESVGV RPDAVVGHSQ GEIAAAVVAG ALSLEDGARV
VALRSRAIRG LAGRGGMVSV PLPVDEVRGL LPEGVWVAAV NGPLSVVVAG DPAGLETVLA
SVERARRVPV DYASHSAHVE EIRQEILDVL APVSPRASTV PFFSTVDVEW ADGTGLDAGY
WYRNLRRPVQ FEAAVRELAG DGYGAFVEVS AHPVLTMPVE ETVEDIGGDT AVLAVGTLRR
DEGGLHRFLT SAGELFVRGV EVDFTPFYGG VPPYRDLPTY AFQHKRYWLE DSIGMAESEQ
NLFWRTVEDG GLGELLGLDP RTPLSDVLPA LSDWRNRHDT RATVDSWRYR VTWKALSGGG
TGRWSGHCLL LVPETGHPLV DEVCRALEDA GATVTRVELT AADSDRRTLA RRIAEVPRPL
DRVVSLAGLD ERPHPEHAVV PVGTALTLAL VQALADAGVD ATLWCLTGGA VSTGDDGVAP
RAAQNLVWGL GRVAALEYPR RWGGLLDLAP GFDPAALVTA LAGHGDEDQL ALRPGAAYGR
RLERAPLPDG PAPAPWRPRG TVLITGGTGA VGGQIAAWLA RNGAEHLVLL SRQGSDAPGA
AELTAELESL GARVTTAACD VTDRGQLAAL VADLEARGEP VRSVMHTAGA GRLVPLPDTD
LAEFGDTLHA KVLGAAHLDE LIGEVDAFVL FSSISAVWGS ADHGAYAAAN AYLDGLAENR
RARGLAATSV VWGIWAPQDG KGMAANLAER QLRGRGIPFM RPALAIEGFQ QVLDRDETVV
VVAAVDWGRF APVFTSARPS PLISDLPDAR AALAGQDDDT TALGTAGSPL LDRLRPLSAA
EQRELLAELV RTQAAAVLGH DSAAEIEPGR ALRELGFDSL TAVELRNRLN AATGLRLPVT
VVFDHSSAAA LAGHLRDELL GTAAAPAVPV AVTVPAGDDP VVIVAASCRY PGGVRSPEDL
WRLLAEGRDA ISELPGDRGW DLGGVYDTDP DRPGTTYSRA GGFVYDAGLF DPAFFGISPR
EALAMDPQQR LLLETSWEAL ERGGIDPTAL RGTPTGVFVG ASYQGYGGGG ERVPEEAEGH
LIAGISSSVL SGRVAYALGL EGPALTVDTA CSSSLVAVHL AAQALRSGEC SLALAAGATI
LGSTLSFTGF SRQRGLAADG RCKPFGAEAD GFGIAEGVGV LLLERLSDAR RNGHPVLALV
RGSAVNQDGA SNGLTAPNGL SQQRVIQQAL ANAGLDPADV PVVEAHGTGT KLGDPIEAQA
LLATYGQDRD ADRPLRLGSV KSNIGHTQAA SGVAGIIKML QAMRHGTLPR TLHADVPSPF
VDWSAGTIEL LTEARPWEGP RRAGVSSFGM SGTNAHVIIE QADPVEEPAA EDDGPAPTVA
WTLSGRTEEA VRDQARALLD RLDTELLDAG PLDIAHSLAT RAAFERRAVV VGAHREELAA
GLRAVRDGEA PVHTADAGRR TVFVFPGQGT QWTGMALELL ESAPVFAERF AECERALAPH
LDWSPSEVLR SGDYEQVDRI QPVLFSVMVS LAALWRSCGV EPDAVVGHSQ GEIAAACVAG
ALSLEDAATV VALRSKALTA LAGQGTMMFV AMAAEPLRER VSAWGGRIGV AAVNGPASAT
VSGDPEALEE LSAALSDEGV LRWPIPGADF AAHSAQVERI HDELLRVLDG VTPRPAAVGF
WSTTAGAWLD GSALDAAYWY RNLRETVEFD RAVHQLIADG YDTFVEVSPN PVLAIWVQQA
MEAADGGVVV GTLHREAGGP DRFLTSLGEL YACGAAVDWS AVHRGGRRVD LPTYPFQRQH
YWLVPRPLAP RDLPAAEDTA AWHYRVEWRV RHDLPSRRAT GDWLVVTPDG TDVTAHLEAL
RRHGLTPLVV PWEAADDRTT GAARLRAAAD GHEPAGVLSL LGLTDRPWSD ETVLPAALPM
TVALLGALGD AGIDAPLWAA TRGAVSVGPA DPVTAPAQAA LWGLGGAAGV EYPDRWAGLV
DLPAVLDDQA AQRLLAVLTG EPGEDQVALR PSGVHCRRLA HADRPGPAPA RPWQPGGTVL
VTGGLGALGG HVARWLATAG AEHLLLTGRR GADTPGADEL TAELRALGVH VTVAACDVAD
RDAVAELLAG IPAETPLTAV VHAAGVLDDG VVDSLTADRA AGVARPKADA ALVLHELTRE
TDLSAFVLFS SLASTLAGTG QGGYAAANAF LDALALHRRD LGLPATSVSW GLWGGRSLTD
EAVAARLVRD GLPAMDPARA VAALPQAVGS GEPHVIVSDF AWDRFVAAFT SLRPSPLIAD
LPEVAALTAQ AAPERTAAPD RAALLELVRT AAAEALGHDG ADAIGRDRVF KDLGCDSLTA
VELRNKLSAA TGLRLPVTLV FDHPTPAAVV DHLMTELGEP DVRTGTATDA AAAGTDDPVA
VVGLSCRFPG GVRTPEDFWR LISEGGDAIT PFPTDRGWDL DALYDPDPGH HGTTYVREGG
FLHDLADFDP AFFGISPREA ATIDPQQRLL LETTWEAFER VGIDPRSVKG SRTGVFVGSS
YHDYGLRVRN APEEVEGYLG IGSAGSVASG RISYTFGLEG PAVSVDTACS SSLVAIHLAA
QSLRSGECTL ALAGGAAAMA TPTSFIEFSR QRGLSADGRC KPFAAAADGT AWAEGVGLVV
LERLSDARRH GHPVLALVRG SAVNQDGASN GLTAPNGPSQ QRVIRDALTS ARLTPAELDV
VEAHGTGTKL GDPIEAQALL ATYGQDRDRP LLLGSVKSNI GHAQAAAGIA GVIKMVLAMR
HGTVPATLHV DEPSPFVDWS AGRVDLVTEN TPWPETGHPR RAAVSSFGVS GTNAHTILEQ
APDDEPAATA GRREPLPVPL VLSARSAPAL RAQADLLDRH LADHPDLRLA DVAHTLATAR
AHLEHRAVVP HGDRDAVRAA LRSVTGSVPP AEPRVAFLFA GQGSQRPGMG LRLHREFPVF
AAAFDAVCAA LDPLLDRPLH EVLGAADPED AGLLDRTAWT QPALFAVEVA LFRLTEHWGL
CPDLLLGHSV GELAAAHVAG VLSLPDAALL VAERARLMQA MRADGAMVSV MAPEETVLPY
LAEYGDRVTV AAVNSTVATV VAGDEDAVLG LADRLAADGR KTRRLRVSHA FHSPHMDAML
EEFGQVAARL EYHPPRIPVV SNVTGEIAGA DELCTPDYWV RHVRGTVRFL DGVRALERAG
VTAYVEIGPD GSLTAPAQDC LEHPAVLIPL LHRDRDETEA VTAALGRYHA EVAAPDWERV
LEDRDVRRVP LPTYAFQRER HWLDDTAGAG DVTSAGLLAT GHPLIGAAVE VAGTDTYVFT
GRLSPHDTPW LADHEVFEEA LFPATAFLEL AVRAADEVGC ARVDELSLAA PLVLPEDGAV
VLQMRVGPQD ADGTRGLEVF SRPQHAPDGE GWTRHADGVL SPGATPVAPA AATLTQWPPP
GAELVDVTGL YERFAESGFA YGPAFQGLTA VWRRGEEVFA EAALPASLRS EAGRFGLHPA
LLDSVLHSLA FGVLSGSGRA WLPFAWSGVT LHAAGAAAVR LRMAPTGDSS MSVVLADGTG
APVATAESLA LRPAAPARTA TGGGRTHRTL FRPEFTEIPL PAAPSPVPAF ETRGYEPGQD
AAAVRRATRR ALADIRDWLA ADRAGAKLVF TTRGAVPATP DSDVTDLAGA AVWGLVRSAQ
TEHPDRFVLV DHDYEDRDQA AAAVARVLAG AEPQIALRDG RAYAHRIARV PVGAADAAPQ
WERGGTVLVT GGTGAIGAHV SRHLVTAHGV KRLLLTSRTG PAGEGTARLH RELTALGAHV
EVAACDVADR DALAALLAGV PSEHPVTAVV HTAGVVQDGI VASITDEQLD ATLRPKVDAV
LNLQDLTGPD LSAFVVFSSI AGVFGGMGQA NYAAANAFLD ALAHHRRARG LPAASLAWGL
WANDTGMSGH LDANDFKRIA RGGIIPFPPA EGLELFDTAL AEDHPVLLPL RLDTDAVQAQ
GEVPAVLRGL VRPAVRRTAA GTGADGAAGL ARRLSAMTDT QRRRALLDLV RDHAATVLGF
ADAGSLDVDR GLLEVGFDSL TAVELRNRLG AASGLRLPAT LLFDHPTCRA VAGHLADELA
PGPDTGQLPG LAELERLSTL LDDERHREEL TGRLHDLLAK ARGAAGGDVV EERLDAADDD
EIFAFIDNEL GMS
//
