ID A0A3Q9WJW8_9MICC Unreviewed; 458 AA.
AC A0A3Q9WJW8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Cystathionine beta-synthase {ECO:0000256|ARBA:ARBA00026192};
DE EC=4.2.1.22 {ECO:0000256|ARBA:ARBA00012041};
DE AltName: Full=Beta-thionase {ECO:0000256|ARBA:ARBA00030337};
DE AltName: Full=Serine sulfhydrase {ECO:0000256|ARBA:ARBA00031579};
GN ORFNames=MN0502_26210 {ECO:0000313|EMBL:BBE23738.1};
OS Arthrobacter sp. MN05-02.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=1571833 {ECO:0000313|EMBL:BBE23738.1, ECO:0000313|Proteomes:UP000283134};
RN [1] {ECO:0000313|EMBL:BBE23738.1, ECO:0000313|Proteomes:UP000283134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MN05-02 {ECO:0000313|EMBL:BBE23738.1,
RC ECO:0000313|Proteomes:UP000283134};
RA Ii KM., Kono N., Paulino-Lima IG., Tomita M., Rothschild LJ., Arakawa K.;
RT "Complete genome sequence of Arthrobacter sp. Strain MN05-02, a UV-
RT resistant bacteria from Sonoran Desert.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-homocysteine + L-serine = H2O + L,L-cystathionine;
CC Xref=Rhea:RHEA:10112, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384,
CC ChEBI:CHEBI:58161, ChEBI:CHEBI:58199; EC=4.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001175};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
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DR EMBL; AP018697; BBE23738.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3Q9WJW8; -.
DR UniPathway; UPA00136; UER00201.
DR Proteomes; UP000283134; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004122; F:cystathionine beta-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:UniProt.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0019343; P:cysteine biosynthetic process via cystathionine; IEA:InterPro.
DR CDD; cd01561; CBS_like; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR005857; Cysta_beta_synth.
DR InterPro; IPR001216; P-phosphate_BS.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR01137; cysta_beta; 1.
DR PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR PANTHER; PTHR10314:SF194; CYSTATHIONINE BETA-SYNTHASE; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00291; PALP; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS00901; CYS_SYNTHASE; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000283134}.
FT DOMAIN 339..401
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 458 AA; 48629 MW; 49C45C5C4270920C CRC64;
MKYANSIVDL IGNTPLVRLN SVTDGIAATV LAKVEYLNPG GSVKDRIAAK IIDAAEAEGK
IKPGGTIVEP TSGNTGVGLA LVAQQRGYNC VFVVPDKVGE DKRNVLKAYG AEVVVTPTAV
APDSPHSYYG VSDRLVREIP GAYKPDQFSN QNGPLSHYET TGPEIWNDTD GKLTHFVTGV
GTGGTITGTG RYLKEVSADR DGGPVRIIGA DPDGSIYSGG TGRPYFVEGV GEDMWPESYD
PSIPDEIHGV TDAESFEMTR RLAREEGLLV GGSCGMAVVA ALRVAKDLTA DDVVVVLLPD
GGRGYLGKIF NDDWMKSYGF LSGGGEASVG EVLRAKSGSL PDLVHTHPTE TVRDVIAILA
EHGVSSVPVL SQKPPVRMGE VLGSVDERSL TEKIFNGEAQ LTDQISQHMD AKLPLIGSLE
SVETARERLQ DSDTLMVTHV GSPVGILTRH DLLTYMSK
//
