ID A0A3R5X0C4_9FIRM Unreviewed; 612 AA.
AC A0A3R5X0C4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=BlaR1 family beta-lactam sensor/signal transducer {ECO:0000313|EMBL:RGS82328.1};
GN Name=blaR1 {ECO:0000313|EMBL:RGS82328.1};
GN ORFNames=DWX73_01310 {ECO:0000313|EMBL:RGS82328.1};
OS Coprococcus sp. AF21-14LB.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Coprococcus.
OX NCBI_TaxID=2292231 {ECO:0000313|EMBL:RGS82328.1, ECO:0000313|Proteomes:UP000285019};
RN [1] {ECO:0000313|EMBL:RGS82328.1, ECO:0000313|Proteomes:UP000285019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF21-14LB {ECO:0000313|EMBL:RGS82328.1,
RC ECO:0000313|Proteomes:UP000285019};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M56 family.
CC {ECO:0000256|ARBA:ARBA00011075}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGS82328.1}.
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DR EMBL; QRVX01000003; RGS82328.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R5X0C4; -.
DR Proteomes; UP000285019; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd07341; M56_BlaR1_MecR1_like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR008756; Peptidase_M56.
DR PANTHER; PTHR34978; POSSIBLE SENSOR-TRANSDUCER PROTEIN BLAR; 1.
DR PANTHER; PTHR34978:SF3; SLR0241 PROTEIN; 1.
DR Pfam; PF05569; Peptidase_M56; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000285019};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..318
FT /note="Peptidase M56"
FT /evidence="ECO:0000259|Pfam:PF05569"
FT DOMAIN 398..599
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 612 AA; 69541 MW; E1E871F8BA31B187 CRC64;
MILNDSFWYF LDRFGTHFFL CNLFIGLFVG LLAGFKRLFQ TYLSSGARYR LWFFFLALLP
LPFLPRELFA LLKKIPYGSF SQAAQTGLAF RETSQNSGTF VSAFNELNDF AVSVRSSVPS
LLPILFSILW GIGVLVMLLI TVRSVLHLRA LKHSALPIAD PELVHLYLRC CQEIHFTKKV
PLYRTDSLTS PAAAGVWNPC IYLPDTVIAD SAIEELRFIL LHELQHIKQK DGIIICLTSL
ASIFYWCNPA VHYALREIRF CRELACDTAV LHCLKSSEYR TYGITLLNFA EKSSLRHTAM
TAGIYSGKHQ MKQRILNIAA FHRQTKCQKF QSLLCCLTAA FLFFGFLPVF AFAGMEQDTY
KLPEEIQNIS FLNLSDIFDD YDGSFVLYDT KDDSWKIYQP QLAKTRVAPN STYKIYDALL
GLETGIITSE NSLRSWDKTP CPFPEWETDQ TLATAMKNSV NWYFHSLDSQ IGRERIQSFL
QKIHYGNQKM SSDLSLYWTD ASLKISPIEQ VLLLKSFHNN DFSFAPKHIA AVQDAIRISS
SPDAVLYGKT GTGRIDGQDV NGWFIGYVEM PDRTCYFATN IQGNSNTTGQ KASEITASLL
SKFHIYPQDG QQ
//
