ID A0A3R6VXP9_9CLOT Unreviewed; 271 AA.
AC A0A3R6VXP9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=5-proFAR isomerase {ECO:0000256|ARBA:ARBA00031376};
GN Name=hisA {ECO:0000313|EMBL:RHU79211.1};
GN ORFNames=DXC26_17240 {ECO:0000313|EMBL:RHU79211.1};
OS Clostridiaceae bacterium OM08-6BH.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae.
OX NCBI_TaxID=2292274 {ECO:0000313|EMBL:RHU79211.1, ECO:0000313|Proteomes:UP000284832};
RN [1] {ECO:0000313|EMBL:RHU79211.1, ECO:0000313|Proteomes:UP000284832}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OM08-6BH {ECO:0000313|EMBL:RHU79211.1,
RC ECO:0000313|Proteomes:UP000284832};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- SIMILARITY: Belongs to the HisA/HisF family.
CC {ECO:0000256|ARBA:ARBA00009667, ECO:0000256|RuleBase:RU003657}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RHU79211.1}.
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DR EMBL; QUKV01000022; RHU79211.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R6VXP9; -.
DR Proteomes; UP000284832; Unassembled WGS sequence.
DR GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:InterPro.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd04723; HisA_HisF; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011858; His6-like_euk.
DR InterPro; IPR006062; His_biosynth.
DR InterPro; IPR044524; Isoase_HisA-like.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR02129; hisA_euk; 1.
DR PANTHER; PTHR43090; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR PANTHER; PTHR43090:SF2; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR Pfam; PF00977; His_biosynth; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW ECO:0000256|RuleBase:RU003657};
KW Histidine biosynthesis {ECO:0000256|ARBA:ARBA00023102,
KW ECO:0000256|RuleBase:RU003657}; Isomerase {ECO:0000313|EMBL:RHU79211.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000284832}.
SQ SEQUENCE 271 AA; 30223 MW; 7CF3F0E7ECA32863 CRC64;
MEFRPCIDIH NGCVKQIVGG SLKDEGNQAS ENFVSEQDAA FYAELYRKQG IRGGHVILLN
KESSKYYEAT RQQAFGALRA YPGGLQIGGG IHPENAEEYL EAGASHVIVT SYVFRDGQMD
REHLNRMVRT VGPEHLVLDL SCRRKGDQYY IVTDRWQKFT NVVLTPEVLD ELAGCCSEFL
IHAVDVEGKA RGIEKPLAEM LGAWNGIPVT YAGGIGGFED LRELKTLGRN RLNVTIGSAL
DLFGGPMNYE ETVKFIAQQG EKWYNTDNIK K
//
