ID A0A3R7HUP4_9ACTN Unreviewed; 564 AA.
AC A0A3R7HUP4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:RKM91412.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:RKM91412.1};
GN ORFNames=DC095_009970 {ECO:0000313|EMBL:RNC74952.1}, SFRA_028065
GN {ECO:0000313|EMBL:RKM91412.1};
OS Streptomyces xinghaiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1038928 {ECO:0000313|EMBL:RKM91412.1, ECO:0000313|Proteomes:UP000028058};
RN [1] {ECO:0000313|EMBL:RKM91412.1, ECO:0000313|Proteomes:UP000028058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19609 {ECO:0000313|EMBL:RKM91412.1,
RC ECO:0000313|Proteomes:UP000028058};
RX PubMed=25477406;
RA Bekker O.B., Klimina K.M., Vatlin A.A., Zakharevich N.V., Kasianov A.S.,
RA Danilenko V.N.;
RT "Draft Genome Sequence of Streptomyces fradiae ATCC 19609, a Strain Highly
RT Sensitive to Antibiotics.";
RL Genome Announc. 2:0-0(2014).
RN [2] {ECO:0000313|EMBL:RKM91412.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 19609 {ECO:0000313|EMBL:RKM91412.1};
RA Danilenko V.N., Bekker O.B., Vatlin A.;
RT "Genome sequencing of Streptomyces fradiae ATCC 19609.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RNC74952.1, ECO:0000313|Proteomes:UP000245280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OlgR {ECO:0000313|EMBL:RNC74952.1,
RC ECO:0000313|Proteomes:UP000245280};
RA Danilenko V.N., Bekker O.B., Vatlin A.;
RT "Genome sequencing of Streptomyces xinghaiensis (fradiae) OlgR.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKM91412.1}.
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DR EMBL; JNAD02000017; RKM91412.1; -; Genomic_DNA.
DR EMBL; QFBD02000003; RNC74952.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R7HUP4; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000028058; Unassembled WGS sequence.
DR Proteomes; UP000245280; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR041040; 3HCDH_RFF.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF18321; 3HCDH_RFF; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:RKM91412.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028058}.
FT DOMAIN 64..242
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 245..342
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 409..474
FT /note="3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-
FT fold"
FT /evidence="ECO:0000259|Pfam:PF18321"
FT DOMAIN 475..559
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 57801 MW; 019620CCA30F960D CRC64;
MTAAEPTPAP GGEARADSVR LSGDAAPTAP APAPAAPAPA SAPAAAGTAP ATAQATAPLG
TDRTVAVVGT GTMGAGIAQV ALVAGHPVRL YDAVPGRAAE AAEGIAARLG RLVEKGRMTP
AGRDAARARL TPAAGIAELA DAALVVEAVA EDAEVKRGLF TALEEVVADD CLLATNTSSL
SVTAVAGALR RPGRFLGLHF FNPAPLLPLV EVVSGFATDA PAADRAYATA AAWGKTPVRC
TDTPGFIVNR VARPFYAEAF RVYEERAADP ATIDAVLRES GGFRMGPFEL TDLIGQDVNE
AVTHSVWESF FRDPKFTPSL AQRRLVQSGL HGRKSGRGWY AYDEGAERPA PPTAPPCEAP
AGVTVHGDLG PAAPLPGLIE EAGIGITRGE AARPGAGAGF IALPNGTRLA LADGSPATTD
EAGMYIKFDL ALDYRTAARI ALAPSERADP EAVAAAIGLF QALGKQVSVV GDVPGLIVAR
TVALLVDFAA DAVGRGVASA EDTDTALRLG VNYPRGPLEW GDALGAGWVR DVLLNLHRVY
PTGRYAPSPY LLRRAAAGQN LLES
//
