ID A0A3R7JB56_9STRA Unreviewed; 4143 AA.
AC A0A3R7JB56;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=IPT/TIG domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BBO99_00001466 {ECO:0000313|EMBL:RLN84239.1};
OS Phytophthora kernoviae.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=325452 {ECO:0000313|EMBL:RLN84239.1, ECO:0000313|Proteomes:UP000285624};
RN [1] {ECO:0000313|EMBL:RLN84239.1, ECO:0000313|Proteomes:UP000285624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chile4 {ECO:0000313|EMBL:RLN84239.1};
RA Studholme D.J., Sanfuentes E., Panda P., Hill R., Sambles C., Grant M.,
RA Williams N.M., Mcdougal R.L.;
RT "Genome sequencing of oomycete isolates from Chile give support for New
RT Zealand origin for Phytophthora kernoviae and make available the first
RT Nothophytophthora sp. genome.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLN84239.1}.
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DR EMBL; MBDN02000021; RLN84239.1; -; Genomic_DNA.
DR STRING; 325452.A0A3R7JB56; -.
DR Proteomes; UP000285624; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00102; IPT; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF00630; Filamin; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13418; Kelch_4; 1.
DR Pfam; PF12777; MT; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00557; IG_FLMN; 1.
DR SMART; SM00429; IPT; 1.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000285624}.
FT DOMAIN 345..435
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REPEAT 435..551
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT DOMAIN 1365..1503
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2003..2153
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 3286..3315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2572..2599
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2822..2877
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3143..3205
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3298..3314
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4143 AA; 465474 MW; 24C19CC3322653E0 CRC64;
MPIGYGCEPE LAWIAPKQGG EIPVKRSGHS FTLKSTETET AVYMFGGCDH KSPPGPTDEL
HKLDVTNGYS WSKVISSHTE EGTPPPRWRH SAILFEKNII IFGGFAAEKR MNDLWLFNTE
LKLWEQKYAQ GFWEGLPQCR GAHSATLVGD KMYVFGGYGG NGFGRTDFND LHALDLHSYK
WQEIQANGEK PEPRSGHQTC LVKEQLLVIG GWNSFKQFQD IFVFDMPTST WSLLTTPLQF
PIWNHTCVSV AAVPHWKVFL FGGNSGDLAE SGTAQGAYLN STSVLDTGSM VWLSPPVKGE
LPKARADTSM VFDANTNHLI FFGGWANRWY NDLHVLNAAE IVGPPYSISS IEPKQGPITG
SAKVKVTGFN FTGQNATLRF AVTKGSVDVT GTVLSPTVIQ ATAPSFEKFG SLSAEVRVSL
SGGMYTNVST SFRFHSVTAA PKSLAFGPCL IAALSDNCMA EVPTTFIVQA RDKDDNPRDC
GGDEFIITLK YCDDPHVEEE KIISITDKND GTYVVTFTPA KPGKYEISVI FAGTFNGAEG
PIRGSPFTAL FQEPTDENKT KCLPPLATQK DLDSPDLIRR VMATMNKRNG EFRRILVDLR
KDIPSNDTDG LETLRKMKEI IRKLEIDKGT NHLILDQVRQ LFFNIKKNGG HVDKELVEIE
SMEKLFVDVE KQVPLTEKRT QEPTRIFSEK TEEKIIAYEK TIAQKMETLK TLDFWSSNLE
PDKGLEKIEN YLVDWNMEMK KCEENTKLCS TFGFPQLMNE SLRMMGLMRA DADAMKTVWA
IIKRAKAFFK DTQEILFKEV DVNALQIEVQ SSLKELKKIP KGIQWSDAYT SILKECQAFD
KTHPLIRCVS SSYMRPRHWK RIMVKTGEFP TPDEDPNQKL SLIMSKNLFN FSSDINEICY
EAEKEQELEL RLIELEALWA EVNWEMTTYN PGAAEEDIVP LLKVSEENFE LLETHQIDVQ
GMSASPYQSE FEPRVASLQI GLSSINEVVL LLGDIQRSWS YLEPLFIQSE EVKKQLPELT
ADFEDIDVEV RQILKKAWAT LNVQVACTEV GLIKRLESIV EKLELCKHRL KEFLDGRRRQ
FPRFYFMSEA DLLDILSNGS HPDRIMPHCS KIYLATKTLT LVDRAGGERP VATSFVAGVG
HEVVDFFEPP VLNGEAEIYL ETIMRAMRLT LFKHIERSLV AYTEMPRVDW INFKDDTNKP
MDAAQIILLA AGVHYVQEVE RSFRSIQNGE KDTLKNYNKM QEKQLEDLIK LTQSNISYAE
RQRVMVLITM DAHGRDIVAN MIRAGVEEAS HFMWQSQLKH YFSPVAGSFQ KRDMNFRGAN
NARAQILICD AGIPYDYEYL GNGPRLVITP LTDRIYVTAT QALNLMMGCA PAGPAGTGKT
ETTKDLANAL GKVCYVFNCS PEMDYKSLGN IFKGLASSGS WGCFDEFNRL VPEVLSVCSV
QFKAVCDACK ADDEKFILEN DDVALDPTVG AFITMNPGYL GRSELPEGLK ALFRPMTVMV
PDLVLICENM LMAEGFTQAK ILASKFYGLY SLLGQLLSKQ MHYDWGLRAV KSVLCVAGAF
KRAEPDIPET DLLMRALRDF NIPKIVAEDM VIFFGLLGDL FPRDSPNVDV RNDPPRKRDM
ELESMVQGAS EAIGNTPRPE FMLKVVQLSE LLAIRHCVFV MGPPASGKTE TWKTLRKARE
IMGTPMEVQD LNPKSVSTNE LYGYIVLKTR EWKDGLLSRI MRDLGSRRRD NGDEDNNPKW
IILDGDLDAN WIESMNSVMD DNRMLTLASN ERIPLKVHMR MIFEIRDLVY ATPATVSRAG
ILYISTSEGY QWRCLIDSWI DRHCQQPVDH RLRNMMFTPD TRAKFQGLFD QYIDTTLRFF
RKKVVPVVPV EETTLVTNLL NMIDCLLTPQ VLEDFTVMQN TFVFCCVWAF GSILTLSDDG
TDYSAEFSNW WKNQWKDVKL VASASNTVFD FWLDPETSKF NSWSKSPYFY TETYKSPSPI
NQITVPTTET ASIAFWLENL ISKSIPIMVC GPAGTGKTQN IMGMLKKLSK DEATAAFRYC
TINFNFYTTS AILQQTMFGQ LERKTGINLG PPGKARLIYF MDDLNLPEVD PYNTQSAISL
LRQVMEYKHW FDRVKLQTQN ILNTQVVAGM NPTAGSFLVD PRLQRHFCTF AMGMPEAPSL
VTIYETFLGG HLSGTFRKTA ANFHYEFNVR HLSNVFQGLI ASKKDRFNSS EKFILLWLHE
SERVYGDRLV CKADIEKYNQ LVQMQVKKSF ASCNTSRYYA AENSWPLIFC HFTKDGDSEY
DQIMGTNLDD LKANLQIQLR EYNNNENNTA MQLDLFDDAV KHVARIVRIL RNESGHALLV
GVGGSGKRSL ARLASHICGY TVRQITISSK YGENEFKEDL RKMHMVVVEM LSRNEEDGGV
VFMLTDSQIT NEKFLIYLND LLASGEIPDL FAMEDMDNIV NLLSPVAGTK DRKEVIKFFQ
AEIRKRLHLC LCFSPVGDDF RNRARKFPAL VNCTVIDWFQ PWPKEALLSV GREKLKEIGD
LLGSEESREG IEKFMPFSFQ SVNICAERFF QVERRHVYTT PKSYLELLQL YKKILRKKVE
EYAAAIDRLE KGLQKLKETG DTVSRLEVEL KVILEAAEDK KAVASGIAEA VNKEKANVET
ESKKAGDEAA KCAIIQTEVT EKQRSTQEDL AKAEPAVAQA MAALDSLNKK DLGECKTMSK
PPAGVDDVFS ATMVLLAGVH PNVQVTKTGK VKDVKWDTAK KQLLGNIPEY IDYLVGFKQV
VDDGKVPPMN WKEVRVFLEM EHFNYDTILT KNKAAAGLCS WVINIVMYYD IVITVEPKRQ
ALAAANTELE AANARLAEVT ALVADLQAKL DKLLAEAAAA EKEKEDAVNA VETGNRKMKL
AGTLTNDLSS ENVRWGINVL QLQKEKDLLV GDVLLASAFI SYIGPFTKPF RDELINKHWV
PYLRTAAGGE SIAMSEEANP LLILTNDAQI AQWNTQKLPS DRVSSENGAI VVTTVSMGRR
PLIVDPQLQA IAWIREMEAH NNLIIVRVGQ KMWIERLKTA IGTDGAFLIE NLSEKIDPIL
APVIQRSTSR RGARYEIQIG DASVPYNDNF HLYLHTKLGN PHYPPEIQAE CTIVNFTVTM
LGLEDQLLNL VVSKERQDLA IKREKLIQEQ NNGKIELKKL EDDILFYLAS ADDDITNNQP
LIQILSDTKH KAQRTQNNME AAKKTQESVN ITSEKYRSIA ARGSLLFFLM SDISKVHSYY
IYSLASFQQV FLSGIYRAPA LITANANEAE GSAAREGEGA ATGNAAIVVT PGENVEGGEG
SGDEENEREE PAVPDLTDEE MHSRCQVLMD SITSCVYNYV RRGLFERNKL TVATMLCLKI
LLKDGLLHDS EVEYFLISKA HPDAGNAGSA SEWLPAAIWA KLKALESAKV FQGLGDAIQN
DPDEWRKWFA TEDAERQKVP GDFVKLTTFQ RLILLRAMRP DRVTNALRTF ILESLGEEYV
TQPPFNMEST YAETNSSIPI FFVLFPGVDP TPWVETLGKA NGVSLENNNF INISMGQGQE
AYAGEALKRL STEGGWIILQ NVHLMQSWLP TLERQLEEVA TEGAHDLFRC FISAEPPPLP
DMLNIPESLL QSCIKVANEA PSDIQSNLRR AWANFGEDKV QACTKPAEFK ACLFSLCWFH
AIVLGRRRFG QQGWSRAYSF NTGDLTICAN ILHSYLDNNP SVPWDDLRYL FGEIMYGGHI
TDAWDRRTNN TYLTVLIDPG LLNGMELGPG FKSPNPNEFS FADYANYIEK NMVPEAPPLF
GLHPNAEIGY LTTTCETLCY TMVTIGGGAG GGGGGGEEGG GVDKTTVLRA IIEDLETRCP
EFFNMLDVVE AATPHLTEDH GPFVVVALQE CSRMNVLLQE IRLSLGDLKK GLNGQLNMSQ
AMEDLATAMT LNEVPGRNPF SQCKWEKKAW PSTKSLSGWF ADMVKRHEQL VMWAGDTTGG
GGNCFVTPFS IWLPGLFNPT AYTTACLQVT SRKRFMPLNQ MTVETHVTTI QDPSTISNYP
DDGVFVHGLI LEGARWSTLD EINERYPVGA SPPTECGGTL LDSNPKELLW SMPVIYVKAV
TTSPTWEPSS VGYLRHDPSI YECPVYLTRF RGHTYILLAT LPTDCGSAKW VLRGVALIFQ
DDN
//
