ID   A0A3R7JET6_9EURO        Unreviewed;       385 AA.
AC   A0A3R7JET6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 9.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=CFD26_102731 {ECO:0000313|EMBL:RLL96204.1};
OS   Aspergillus turcosus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1245748 {ECO:0000313|EMBL:RLL96204.1, ECO:0000313|Proteomes:UP000215289};
RN   [1] {ECO:0000313|EMBL:RLL96204.1, ECO:0000313|Proteomes:UP000215289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMR AF 1038 {ECO:0000313|EMBL:RLL96204.1};
RA   Parent-Michaud M., Dufresne P.J., Fournier E., Martineau C., Moreira S.,
RA   Perkins V., De Repentigny L., Dufresne S.F.;
RT   "Draft genome sequences of two Aspergillus turcosus clinical strains
RT   isolated from bronchoalveolar lavage fluid: one azole-susceptible and the
RT   other azole-resistant.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLL96204.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NIDN02000119; RLL96204.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3R7JET6; -.
DR   STRING; 1245748.A0A3R7JET6; -.
DR   Proteomes; UP000215289; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000215289}.
FT   DOMAIN          14..282
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   385 AA;  42598 MW;  24F2F3C81B17E8E0 CRC64;
     MTREHSPLRL STVLVTGGSG GLASQILHLF SQRGCKSLHS IDLRQPSHLL NGVTYHLGDL
     TDVDAMRQIF HKVKPDVVIH TASPKFDTPN HIMYKVNVEG TKNLVRIAQE SGTHSFVYTS
     SASVISDGKT DLKNADETFP IILGDQQPEF YVHTKALAET YVLSQNRRSG DTDTSPHFLT
     CAIRPSGIFG VGDQVVLPGI LDAYFRGQTK VQIGDNRNLF DFTENTNVAY GHYLAAAALV
     GCQNDLPLPG DEAKVDGEAF FITNDEPRCF WDFTRLVWGY AGDTTRPEQV WVISRPWALV
     LAGLLEWVFW ALGLGEAPLT RTKVRLSCMT RYFCIDKAKE RLGYKPLVGL EDGLRTAVED
     CVRRRMAAQS QASPLLAGNG KEKGQ
//