ID A0A3R7LS44_PENVA Unreviewed; 1130 AA.
AC A0A3R7LS44;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Toll-6 {ECO:0000313|EMBL:ROT61494.1};
GN ORFNames=C7M84_020722 {ECO:0000313|EMBL:ROT61494.1};
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT61494.1, ECO:0000313|Proteomes:UP000283509};
RN [1] {ECO:0000313|EMBL:ROT61494.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT61494.1};
RA Zhang X., Yuan J., Li F., Xiang J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROT61494.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT61494.1};
RA Sun Y., Gao Y., Yu Y.;
RT "The decoding of complex shrimp genome reveals the adaptation for benthos
RT swimmer, frequently molting mechanism and breeding impact on genome.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT61494.1}.
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DR EMBL; QCYY01004139; ROT61494.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R7LS44; -.
DR STRING; 6689.A0A3R7LS44; -.
DR Proteomes; UP000283509; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF210; CHAOPTIN-RELATED; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000283509};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 674..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 722..857
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 894..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 126331 MW; 624728632021E2FA CRC64;
MMIAARFPLE FCGFDRARPR SGLENVEELA INNCKLDSLP PGTLSSLGRL RSLAVTTHNG
EWAALAMEVV SGSLPLTLER VSLAHNNIWT LPPRAFCGPN SLHHLDLSHN RLQDVHELGF
MDQVQLDILM MNMSNTSFSE HSAVFSNLDE ESSAESHDDL FKGLRRLVIL DLSWNSLTTI
TKLLFRDLTS LQRLVLSHNA IQSLEDDSFT SLSNLYALDL SHNLLLTLGE ANLRGLVGLS
LIHLANNSLF EIHPHAFRHS SNLKQVFLSH NHLQAIPKAL ENLSFIKTLD MSYNNIVSIQ
PFHFGGLGNL EMLNTLDLSM NSLQRINPKS VSMRVASGKH TSAQIYLSGN PLICDCEMEW
LYNSFRSTLT TTPEATEVTF LQPRIDDLAR VTCTLLHSRE DTTVMTRVLE TSAANYLCPY
TTHCFTLCQC CDFIACDCQM KCPDACSCFH DDTWSINLVD CSGGHLDRLP DRVPMDATVV
LLDGNNLQIL HAHHFIGRHS IQQLYLNNSQ IQTLQNRTFH GLTSLQVLHL QDNMIVQLNG
FEFSGLHHLK ELYLQNNRLS FINNATFIGL KSLEVLRLDN NFIIDFPVWL LSNNRYLASV
TLGNNPWDCD CQFVESLREW QKQQSHLLIN PEDVFCVHGD SGVVGPSIIL PEYSCTEAQH
GVTQYKFGQQ ELPFLAGGLC GGVALISALV VMAMLVARRR AAAANKLGIN GSPAYCQEED
GKVFDSYISY SANDASFVRD VLATKLENSC PSYKLCLHSR DFSENSRLSE FITQSLGFSR
RTIIVLSKNY IDNEWKNAIF KKAHVDGLKD NDMGIIAIYY DNVSYSSFDS DLKNIMRRCI
KLRWGDKNFW KKLSEAMPIK QTYAGLPVYV SENSYKSSTL PTLIPPSSLP LPSSSSVLTS
TTGLTTPSEI GHRPSCQQEP PATTYKAPPP PRPCYTPPSC DYIVMTGRDC RDPQCTCHRH
SHTAYTYVDG DSSSLHTYTS LEPFTLPDPH VPESYTRGHS PASSHYSALE PPVRRTVRAS
KRKKKRPLSQ NCPPVHCDTL ENPAFTEDVH GELPSNGTFR RTKSLRASRG NQERHSDYST
DHSSDRSSGR SYDHSVTSGG GVVDRNDALY MGLADSPPEP TMVTTEECFV
//
