ID A0A3R7MMD6_PENVA Unreviewed; 1085 AA.
AC A0A3R7MMD6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Glycine cleavage system P protein {ECO:0000256|RuleBase:RU364056};
DE EC=1.4.4.2 {ECO:0000256|RuleBase:RU364056};
GN ORFNames=C7M84_016558 {ECO:0000313|EMBL:ROT65479.1};
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT65479.1, ECO:0000313|Proteomes:UP000283509};
RN [1] {ECO:0000313|EMBL:ROT65479.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT65479.1};
RA Zhang X., Yuan J., Li F., Xiang J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROT65479.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT65479.1};
RA Sun Y., Gao Y., Yu Y.;
RT "The decoding of complex shrimp genome reveals the adaptation for benthos
RT swimmer, frequently molting mechanism and breeding impact on genome.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC glycine. {ECO:0000256|RuleBase:RU364056}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC ChEBI:CHEBI:83143; EC=1.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043839,
CC ECO:0000256|RuleBase:RU364056};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR603437-50, ECO:0000256|RuleBase:RU364056};
CC -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC T, L and H. {ECO:0000256|RuleBase:RU364056}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|RuleBase:RU364056}.
CC -!- SIMILARITY: Belongs to the GcvP family. {ECO:0000256|ARBA:ARBA00010756,
CC ECO:0000256|RuleBase:RU364056}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT65479.1}.
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DR EMBL; QCYY01003082; ROT65479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R7MMD6; -.
DR STRING; 6689.A0A3R7MMD6; -.
DR EnsemblMetazoa; XM_027372358.1; XP_027228159.1; LOC113820096.
DR Proteomes; UP000283509; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR CDD; cd00613; GDC-P; 2.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 2.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 2.
DR HAMAP; MF_00711; GcvP; 1.
DR InterPro; IPR003437; GcvP.
DR InterPro; IPR049316; GDC-P_C.
DR InterPro; IPR049315; GDC-P_N.
DR InterPro; IPR020581; GDC_P.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR00461; gcvP; 1.
DR PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF21478; GcvP2_C; 1.
DR Pfam; PF02347; GDC-P; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 2.
PE 3: Inferred from homology;
KW Mitochondrion {ECO:0000256|RuleBase:RU364056};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU364056};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR603437-50,
KW ECO:0000256|RuleBase:RU364056};
KW Reference proteome {ECO:0000313|Proteomes:UP000283509};
KW Transit peptide {ECO:0000256|RuleBase:RU364056}.
FT DOMAIN 131..553
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
FT DOMAIN 900..1021
FT /note="Glycine dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21478"
FT MOD_RES 823
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR603437-50"
SQ SEQUENCE 1085 AA; 119802 MW; 23AB48EB0B24968B CRC64;
MPYCPEKRVS LSPSSTMYFY PVLVWRGEGE DARVKSLRVH NVAGSSRWQV AGGFAIEDTG
SEAATDTRAA VRVARCCPVM LDHLARSQGR TVARIVARKV NRGQLGQIRS QGSAAASTTS
LLPAADDFCV RHIGPRKDDQ KRMLESLGYE SLDALTDAAV PENIRLGRDL KVQEPIGEHA
LLGRIREISE KNEIWRSYIG MGYHNCRVPH AILRNIFENP GWTTQYTPYQ PEVAQGRLES
LLNYQTMVTD LTGLPVANAS LLDEGTAAAE AVGLAYRQNK RRKVYLSDKL HPQTLAVVRT
RAIPLGLEVL IGDVFDIDFT NRDVSAVLFQ YPDTEGTVHD FTQVIENAQS NGTMVVCATD
LLAVTVLAPP GDLGVDIAVG TSQRLGVPLG YGGPHAGFFA CKSNLVRLMP GRMIGVTRDA
NGKDSYRLAL QTREQHIRRD KATSNICTAQ ALLANMSAMF AVYHGPKGLK DIANRIHNAT
IILSRGLQSA GHIIENDVFF DTIRVNPTLA TSEIRMRAQQ KEINLRYFRD ETVGIALDET
VEKQDLDDLF WVFNCKNVTA EKVASNLSGA ALPKEHISNT NFARKSDFLT HSIFNTYHSE
AQLVRYLKTL ENKDVSLVHS MIPLGSCTMK LNSTTEMMPC SFPHFTEIHP FVPPEQALGY
RLLFEELEHD LCEITGYDKI SFQPNSGAQG EYAGLRAIMS YLDARGEGHR NVCLIPTSAH
GTNPASAQMA GMKVEAVNVD KEGSIDFRHL TAKIEKHRKN LACLMITYPS TNGVFEETVK
DVCQMVHDAG GQVYLDGANM NAQVGLCRPG DIGGDVSHLN LHKTFCIPHG GGGPGMGPIG
VKAHLVPYLP SHPIVDPMAL MKKKARSFGV VSAAPYGSAA ILPISWAYVK MMGPKGLREA
TQVAILNANY MANRLQKYYK VLYTGNCGLV AHEFILDMRE FKKTAGIEAT DIAKRLQDYG
FHAPTMSWPV AGSLMVEPTE SEDKAELDRF CDALILIREE IRDLEEGRSD PKCNPLNMSP
HPLVTVTSSN WDRPYSREQA AFPAPFVRPE SKWWPTVGRI DDIYGDRNLV CTCPPMETYC
SPFED
//
