ID A0A3R7P1S7_PENVA Unreviewed; 1002 AA.
AC A0A3R7P1S7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Smoothened {ECO:0008006|Google:ProtNLM};
GN ORFNames=C7M84_008556 {ECO:0000313|EMBL:ROT73034.1};
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT73034.1, ECO:0000313|Proteomes:UP000283509};
RN [1] {ECO:0000313|EMBL:ROT73034.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT73034.1};
RA Zhang X., Yuan J., Li F., Xiang J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROT73034.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT73034.1};
RA Sun Y., Gao Y., Yu Y.;
RT "The decoding of complex shrimp genome reveals the adaptation for benthos
RT swimmer, frequently molting mechanism and breeding impact on genome.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT73034.1}.
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DR EMBL; QCYY01002079; ROT73034.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R7P1S7; -.
DR STRING; 6689.A0A3R7P1S7; -.
DR Proteomes; UP000283509; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProt.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF35; SMOOTHENED HOMOLOG; 1.
DR Pfam; PF01534; Frizzled; 2.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000283509};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1002
FT /note="Smoothened"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018547147"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 123..250
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 355..497
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 47..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 110577 MW; 0B9DCB731EABA6E3 CRC64;
MLPRNEAMGN APPHVLVGVL VLITAVISQT AASAITPNTD TLADVSETKT TTESLGKGNS
GNGVSDTLPM IRTNRSKAFV KPTDAPDDTF VGNERASVDP FSFSPEGPFP ASFNDSQNVD
PCKQNAHCEP LEETTCLGVR LPYGQTSLNL TGLPSQQVAR EHLEFWSRLR NIPRCWAVVQ
PLLCAVFLPR CEESSVQLPS QKMCVITRGP CRLVEEDWPP YLRCKEDFPH KCKNSARELK
FNTTGQCVPP LVATEEESSW YEGVKGCGIQ CANPIFTSQE HEDLHQFVAT IGGICLACAA
LTVLTYLIDW RAANKYPVLI IFYINGCFLI ASIGFMVQFH PGVRQDLTCP AGLCGEELER
RAAYFHLIAW SLPLVLTITI MALAEVEADS LAGICFLSSA IHIRIGFLLL PVILIVIIGG
FFLGRGMMKL IYLKMECCTI ISDNANSKIV ETIIRLAIIT ITLVTFTAIT VYCHIYQYKN
QHLWDDALRD YIMCVSNITA DVQDSSRTPC KIAERPSINL YKLHLLALFG AGIIMSSWCW
TPNTIQAWKR FFRRVAGVPS EEPLRLAKHK VIAQAFAKRH DLNNMGRLSI SLHSMHDDPI
GLNFEMNSMT SGDLSSAWAH AIPHLMTRRG ALVGSTALGL RRNSVDSEYS VSRRFSLESG
CNNRSSRRHS LDSQMSFHVS DAERLAALHT AARFGRRKRR DWFSLKRGRR MNAWDRRGSN
TSDDSNLGSM ILPAVTMNQD TLFTNMMKRL NLSSDDPTRS ERTIPSAPPA KSVNLNVVPL
PGQAPLESED DVGAENHAYA DNDSITHTVL NNVLKSVELK RQENYTRAAT ALEEGLLTSA
QGRVSSRRGF TTESRESRGV SIGVQASLIG SPAVIMVDKG VQVSSPLFSR GSQASQTHDW
ELSPTHAYKL QDSGKKTMGE TSFMSQRKLQ NNERPGTPVT KLPKKLNVSN DKSATNKNIN
SSHGSHKRSA SARSGNISGK SRRSRGESAD VITVLDMDED SD
//