ID A0A3R7QHL0_PENVA Unreviewed; 929 AA.
AC A0A3R7QHL0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Integrin alpha 8 {ECO:0000313|EMBL:ROT67722.1};
GN ORFNames=C7M84_014185 {ECO:0000313|EMBL:ROT67722.1};
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT67722.1, ECO:0000313|Proteomes:UP000283509};
RN [1] {ECO:0000313|EMBL:ROT67722.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT67722.1};
RA Zhang X., Yuan J., Li F., Xiang J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROT67722.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT67722.1};
RA Sun Y., Gao Y., Yu Y.;
RT "The decoding of complex shrimp genome reveals the adaptation for benthos
RT swimmer, frequently molting mechanism and breeding impact on genome.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT67722.1}.
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DR EMBL; QCYY01002770; ROT67722.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R7QHL0; -.
DR STRING; 6689.A0A3R7QHL0; -.
DR Proteomes; UP000283509; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000283509};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..929
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018544053"
FT REPEAT 46..106
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 333..394
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 403..463
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 519..665
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 673..808
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 820..916
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 820..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 929 AA; 102926 MW; 5FB40CD0191E425B CRC64;
MVRLRSLEKG RWRGQGAKWH SLHPTLALLC ALALQQTVAF NVNLDDAQVL QPPSQTGIHF
GFSLAHFVNG TERRLLVGAP LANTSKDVSQ PGALYACDLG SSPSCTQLEV DWRNTDDKYK
SWISEDKKEH QGLGFSVVCA PRWHAYESVT GGLKDLASGI CFSARAPNFD KFTAFSPAYD
VIGMNTKFAS YDNNGTCQVG LSVSYSQETE TVSFGSPGCW SWQGDVWNIH KDTLTDKDTF
HRAQKIDFKD VDLTSSPDGR YSSLADLYLG YSVASITYAS KPAVVSAMPR AVSTHDLKVV
EKNKVFGPVI LIFEEDQSKL NVLDTIKPPL NESNNFEATK DSMFSYFGYS LTTADVNGDG
LDDLVVGAPL YHNDSHHDQG AVFVYMQKRF DYGGDGVVGA EMKLEPNSPL RMGHDSYGRF
GSCVASVGDL GGDGYQDIAV GAPFLESGGK VFIYLGSRDG LGKTPSQVID AMDMPSSVRP
LDGFGFAIAQ KMPDATGNGF DLGIGVFNSD KVLVFKTKEV IAVEWNVTFS GKMNLTSSTC
IMAGDTSAGK YPCVDMKTCF LYRVLNTKTK TKQTLEFTIK LEADIKQQKK RLLFNNGRAE
TNLIFNQEKD QMSCQEEKVY AKRDIEELIQ PFVIQAEVDM KGASQSVILD EQATRVLEEE
LPILVQCEGG VADKCESDLE LTYTSNTTYA LKKMESIPVT FRLTNRGEVA YNTRLVINSN
GDLISKEQAD SAGGVVCETK HKPPKIECKI DAIFKKGEKE FEVVMMPHQN FFGSLERHLA
FFTVEAEAET TSVQKNPDAA KTKFQIPIIV KGNLDLTKEN SNPSHVSYNS SYDKSPAEAS
NEQELGEQVI HKYKIYNSNP IRSTHQVDDF WPLKIDGLYL LYLLDNPTIT GIKASCHYEN
GEVDKYNISK RIPDPTEETT FSRDLLRWR
//
