ID   A0A3R8K2N2_9BACT        Unreviewed;      1055 AA.
AC   A0A3R8K2N2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 11.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:RRJ97519.1};
GN   ORFNames=Ga0100231_003060 {ECO:0000313|EMBL:RRJ97519.1};
OS   Opitutaceae bacterium TAV4.
OC   Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae.
OX   NCBI_TaxID=278959 {ECO:0000313|EMBL:RRJ97519.1, ECO:0000313|Proteomes:UP000078325};
RN   [1] {ECO:0000313|EMBL:RRJ97519.1, ECO:0000313|Proteomes:UP000078325}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAV4 {ECO:0000313|EMBL:RRJ97519.1,
RC   ECO:0000313|Proteomes:UP000078325};
RA   Rodrigues J., Kotak M., Lin J.;
RT   "Draft genome sequences of strains TAV3 and TAV4 (Verrucomicrobial:
RT   Opitutaceae) isolated from a wood-feeding termite and in silico analysis of
RT   their polysaccharide-degrading enzymes.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RRJ97519.1}.
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DR   EMBL; LXWU02000002; RRJ97519.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3R8K2N2; -.
DR   Proteomes; UP000078325; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078325}.
FT   DOMAIN          546..617
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1055 AA;  115338 MW;  F53DA36D89E6518A CRC64;
     MLPRTFLTQL IPARVAEATR RLHAQIWQPL PDEAAGIKVA HTPVYREFRD APGLKPSDFT
     PVPEGVSNWG PKYAQRWYKV SLPASIPPPP PLPAASAKGK GKSAANNTDK RTRYLVWNDQ
     AEGTIYIDGV PYSGLDIAHP YIPIPAGTRE LLVESICIRS GIWLGGEATP LDQDGSRYTA
     PGLVLRNDDA WNAYFDLIVL LDLIECEHRD YQPVVGTPKR FTDPVRFSAP AFRASPLFRR
     LCTRLDAAID VLDRDGPAAL SNELKKIYAD FPAESDATGM KAVLTGHAHI DLVWLWPERI
     GERKAVHSWS TQVRLMKEYP EFKFGYSQPA SYDAVKRISP ELHAQVKKLV KAGRWDATGA
     SYVECDTQMP CGEALLRSLR IGQAGFTELR GNPAKVFWLP DVFGYSGCMP QLLVGLGVKG
     FFTSKLSWST VNRFPHTSFR WRGPDGSEIP SHIVLLHDYN EAVNIKNLRE DALHHQQAGI
     HNEFLQPTGY GDGGGGTTEI MIERARRVNS LAGVPKTQWG NIEPFFDRLN EIKDQLPAVT
     GELLLELHRG VFTTHGALKS AFRRIERALQ IQEAAHVVTG SGPIDDYAWR RAAFSHFHDY
     IPGSSIWEVY AEAIPELEKL SAEAIDAAGK VLSTGASAKN ASDKKKSAAA TGLFNPLPIA
     RTWVTDDGRA YELAPLSGAP LAELAAPARI ATPKASLAAS GTATLTSERV TARFDKNGQL
     TALSVDGHNV ALSAVSGKIT QLAAYPDHPA AFEAWDVDRT AIVTGQAAQL AGKGKPAITQ
     TNALTTTISY DYTIAKQSTI TVRYSLTAGE SVLRVAYDID WQDSLMWLKA IFATDYRGRE
     ARYGAPYGSV LRGQWPGYPR EEANWEVAGS RWMTLLDDAQ SEGLALFTES KYGFTVHNGT
     VGLSLLRSAL ITEADHHPKI RETERPFYSD LGQHHIEIAL GRFASDAPLA EQPAVLADTL
     YTPCLPYNGA PVNAGLVSID GAPSLAPSWA EPVKDGWVLR LHETLGRNGT VSVKLANGWK
     AEPLALDGTS LGKPSVGGID LPFTQYKVLS VKISR
//