ID A0A3R8PE56_9CORY Unreviewed; 503 AA.
AC A0A3R8PE56;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245};
DE AltName: Full=Membrane protein YidC {ECO:0000256|ARBA:ARBA00031538};
GN ORFNames=CXF42_09570 {ECO:0000313|EMBL:RRQ02640.1};
OS Corynebacterium bovis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=36808 {ECO:0000313|EMBL:RRQ02640.1, ECO:0000313|Proteomes:UP000278422};
RN [1] {ECO:0000313|EMBL:RRQ02640.1, ECO:0000313|Proteomes:UP000278422}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16-2004 {ECO:0000313|EMBL:RRQ02640.1,
RC ECO:0000313|Proteomes:UP000278422};
RA Gulvik C.A.;
RT "Twenty Corynebacterium bovis Genomes.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|ARBA:ARBA00025034}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration.
CC {ECO:0000256|ARBA:ARBA00026028}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003945}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003945}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RRQ02640.1}.
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DR EMBL; PQNQ01000035; RRQ02640.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R8PE56; -.
DR Proteomes; UP000278422; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000278422};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003945};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..265
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 310..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 55098 MW; F756DFB4784D1A65 CRC64;
MSLLIYPVSV VMTFWHRILT GVLGVSDATA WAVSIVLLVL TVRLFLLPFA YRQFKSTRFL
VNLRPRVAAL EAEFADRHDP GAAREKLRRQ RELQREGGYR MRDGCVPALI QVPFFLGLYQ
LLLRISRPGD LEATEHHGVG VLDGQDVGHF LDASVAGVPL PAYSVMSDEQ FAFLGTTASD
VFHLALPLCI AASVFTTANF GYSLYRNWLT LDHNSALAIS LFRGMWLLLP VLTLFPLIFG
LGGPAPVAIM CYWVMNNLWT LAQSLGLHLT LDRIVPYTPE FMEHRDRMRD ARRARRAEVR
EARRGLARRE RERSRAVRAA SREERRAVAA RVAEESRLDQ IATDRVVHRE RYARAEVKER
RRAEAAAARA AAAAGRKDAG EGAGSGSGSG SGADDDAGAG DRDATTDNGA GDAGQQTGDR
DRTCDDAAPC DCAEAERIRT EFPEDTLDAP YGRHALPVRR SARCGGDVDT HPTPADSTDA
ATPDADSTPG TGRDDTTETD PTA
//
