ID A0A3R9NKB2_9RHOB Unreviewed; 1126 AA.
AC A0A3R9NKB2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=addA {ECO:0000313|EMBL:RSK30307.1};
GN ORFNames=EJA01_16055 {ECO:0000313|EMBL:RSK30307.1};
OS Rhodovulum robiginosum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Rhodovulum.
OX NCBI_TaxID=68292 {ECO:0000313|EMBL:RSK30307.1, ECO:0000313|Proteomes:UP000275159};
RN [1] {ECO:0000313|EMBL:RSK30307.1, ECO:0000313|Proteomes:UP000275159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12329 {ECO:0000313|EMBL:RSK30307.1,
RC ECO:0000313|Proteomes:UP000275159};
RA Gupta D., Guzman M.S., Bose A.;
RT "Draft genome sequence of a marine photoferrotrophic bacterium, Rhodovulum
RT robiginosum.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSK30307.1}.
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DR EMBL; RWGU01000051; RSK30307.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R9NKB2; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000275159; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000275159}.
FT DOMAIN 3..477
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 494..778
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 900..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1126 AA; 121954 MW; 60D33D26DA77234C CRC64;
MTRDAATERQ VQAARPDCST WLSANAGSGK TRVLTDRVAR LLLNEVPPQR ILCLTYTKAA
ASEMQNRLFR RLGAWAMLDD APLRDELRQL GVDSGIGEAM LRRARRLFAR AIETPGGLKI
QTIHSFCAGL LRRFPLEAGV SPQFSEMDDR AARHLRAEIV EEIANGPEVA AFDALAEWHT
SDDLDGLTAE IAGRRAAFAD RPDAGALWRQ FGLAPGTDAA DVLAGVFLGG EAGLLARLGR
AMAAGSTNDI RAADKLAELD PSRPDLALLK GLEGLFLTGE GAKAPFSAKI GSFPTKTTRG
TLGPDLDALD ALMARVEAAR HRRIALAAAQ RTLALHRFAA VFLPAYAARK EARGWLDFDD
LILKARALLT DPGVAQWVLF RLDGGIDHIL VDEAQDTSPV QWEVIDLLSH EFTTGYGARN
DVARTIFVVG DKKQSIYSFQ GADPEEFDRM KDHVAGRLGN VALSLQDLQL EYSFRSADAV
LRLVDCTFPE GARQGLGREM LHRAFRAEMP GRVDLWPLVE RSENPEKPHW ADPVDMLTPE
HHTARLARRV AEQIRAMVEG GAALWDAPKD GPARRRPVTE GDVLILVQRR SDLFHEIIRA
CKSEGLAVAG ADRLKIGGEM AVRDLTALLS FLATPEDSLS LAAALRSPLF GWGEGAVYDL
AQGRGKQYLW QVLRARDCAE SETLSALLDD ADFLRPYDLI DRILTRHDGR RRLIARLGEE
AEDGIDALLA QALAYERMEV PSLTGFLAWM ESDEVEIKRQ LDSAGNRLRV MTVHGAKGLE
APIVILPDTL AGEARLRAQV VAGDGGQPLW RGPADQSPPA EAEAVEALRV RQEEERARLL
YVAMTRAEQW LIVCGAGEAP KSGTSWYQKV AAGMERSGAL PFDFGFGEGK RLETGDWAAG
DLHAPDRTEP EAPALPGWAT ARATPPPRAP QPLSPSDLGG DKALPGEAAG RDAEAAKARG
TWVHALLEHL PGNPRPDRAA VAAQILAAID PPAPDAALPD LLEEAERVLD APHLAKIFAP
ETLAEVEIAA DLPAFAPRML EGTIDRLLIG PDRVLAVDFK TNAVVPASPE DVPEGLLRQM
GAYAAALAQI YPGRTVETAI LWTRAVDLMP LPDALITAAL GRAAPA
//
