ID A0A3R9NUP4_9RHOB Unreviewed; 783 AA.
AC A0A3R9NUP4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=EJA01_03475 {ECO:0000313|EMBL:RSK38000.1};
OS Rhodovulum robiginosum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Rhodovulum.
OX NCBI_TaxID=68292 {ECO:0000313|EMBL:RSK38000.1, ECO:0000313|Proteomes:UP000275159};
RN [1] {ECO:0000313|EMBL:RSK38000.1, ECO:0000313|Proteomes:UP000275159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12329 {ECO:0000313|EMBL:RSK38000.1,
RC ECO:0000313|Proteomes:UP000275159};
RA Gupta D., Guzman M.S., Bose A.;
RT "Draft genome sequence of a marine photoferrotrophic bacterium, Rhodovulum
RT robiginosum.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSK38000.1}.
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DR EMBL; RWGU01000039; RSK38000.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3R9NUP4; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000275159; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000275159}.
FT DOMAIN 32..312
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 313..587
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 53..60
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 783 AA; 86991 MW; 4D24A460144AAB32 CRC64;
MSSIEEDDAF EAAAQGSLSA RAMVARPAPY LDELNPAQRQ AVEALDGPVL MLAGAGTGKT
KALTARIAHL LWTGTARPNE ILAVTFTNKA AREMKNRVGR LMGEAVEGMP WLGTFHAICV
KLLRRHAELA GLKSNFTILD TDDQIRLMKQ LIVAANIDEK RWPARQLAGI IDHWKNRAWT
PEAVPAGEAS AFNSRGVELY AEYQARLKTL NAVDFGDLLL HMLTIFQAHD DVLAQYRRWF
RYILVDEYQD TNVAQYLWLR LLAGGHRNIC CVGDDDQSIY GWRGAEVGNI LRFEKDFPGA
QVIRLEQNYR STPHILAAAS GVIAANKGRL GKTLWTEAEE GEKLRLIGHW DGEEEARWIG
EEAEAMQRGT RGLNPYSLDD MAILVRASHQ MRPFEDRFLT IGLPYRVIGG PRFYERMEIR
DAMAYFRLAV SPDDDLAFER IVNTPKRGLG DKAQQKIQTM ARSNGVPLVD GARLLIESGG
LTGKGARELG KLIAGIGRWH GAVLDARESH IELAERILDE SGYTEHWQND KTPEAPGRLE
NLKELVKALE EFENLQGFLE HVALIMDNET EEGGAKISIM TLHAAKGLEF PVVFLPGWED
GLFPSQRSMD ETGLKGLEEE RRLAYVGVTR AEEVCTVSFA ANRRVYGQWQ SALPSRFIDE
LPEDHVDVLT PPGLYGGGYG AAAPMGSGLE DRASRADVYN SPGWKRLQAR SAERPVSQPR
ESRSMVIDAE AVSAFALGDR VFHQKFGYGQ VTAIEGDKLD VEFDKAGPKK VVARFVTSAD
VPF
//
