ID A0A3R9UDE3_9BACI Unreviewed; 1428 AA.
AC A0A3R9UDE3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Lactocepin {ECO:0000313|EMBL:RSK28653.1};
GN ORFNames=EJF36_18260 {ECO:0000313|EMBL:RSK28653.1};
OS Bacillus sp. HMF5848.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=2495421 {ECO:0000313|EMBL:RSK28653.1, ECO:0000313|Proteomes:UP000274811};
RN [1] {ECO:0000313|EMBL:RSK28653.1, ECO:0000313|Proteomes:UP000274811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMF5848 {ECO:0000313|EMBL:RSK28653.1,
RC ECO:0000313|Proteomes:UP000274811};
RA Kang H., Kang J., Cha I., Kim H., Joh K.;
RT "Bacillus sp. HMF5848 Genome sequencing and assembly.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSK28653.1}.
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DR EMBL; RWIV01000001; RSK28653.1; -; Genomic_DNA.
DR OrthoDB; 9798386at2; -.
DR Proteomes; UP000274811; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02133; PA_C5a_like; 1.
DR CDD; cd07475; Peptidases_S8_C5a_Peptidase; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR Gene3D; 2.60.40.1710; Subtilisin-like superfamily; 1.
DR InterPro; IPR034216; C5a_Peptidase.
DR InterPro; IPR010435; Fn3_5.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR001119; SLH_dom.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF06280; fn3_5; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF00395; SLH; 3.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51272; SLH; 3.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000274811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1428
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038939459"
FT DOMAIN 1247..1308
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT DOMAIN 1309..1371
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT DOMAIN 1372..1428
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT ACT_SITE 170
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 236
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 572
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1428 AA; 151310 MW; 43C9F653949B2D9B CRC64;
MKLKQLFTLL TAILLIFSNA AGYVASAASQ STEKVRVIVE LDQEPGIAYA KKANKKFGDL
SDAEKATLQN KALRQQSYVK QDMNNSKIDI TYKESFTTIF NGFSGEVSAQ DVAKIKQLPN
VKNVYVAHEY KRPAVVADPQ MSSSTNMVTA QKVWGELGYK GEGMVVAVLD TGIDPWHKDM
VLSDETVPAL SEEAVNTFIA EKGLPGKYFT EKVPYGFNYA DENDEILDLG PAASMHGMHV
SGTVGANGNF DDGGVKGVAP EAQLLAMKVF GNDPEMPSTY SDIYVKAIDD AIALGADVIN
MSLGASAAFV KPDDPEQQSI RRAVESGVLV AISAGNSGQI AYGSDMNPFA ANPDIGVVGS
PSLSDESLSV ANLQNEYIEL DAFDFGEGEN AGKATFLSAS SVHPNDLETK TYEIVYAGLG
RLPGDSEADP NADDFKGLDL EGKFALIQRG ETLFVSKALN AQAAGAAGVI IFNHSPGYVT
MASDPAVTIP QLFILQEHGD AINALLDGGD NVSITFSGEK MNALNPEAGK LNDSTSWGVT
PSLDFKPEIT APGTSIKSTV NNDKYELMTG TSMAAPHVAG GAALVLQKMK EDIAAVTGAE
RVQMAKNILM NTATPIADLG TYNAGYGVGN PYSPRRQGAG LMDLYAALQT PVVVTDVTSG
VGKVALKEIG DSATFTLQAE NFGSSDVSYV VSGNVLTDMV MGGTNMLEAQ GIFKNGTIGA
DAPWVGEFPI SFKSAAISEV EGEQVLTVPA GGKVTFEVTV DLADTIDWVY NSPLDEVFDN
GYFVEGFVSL KDRSDMLPEL TVPYVGFHGE WSDAPVLDSF GSSSFFGESG LVSDAVEYAE
GVEAGDADAE PMYDYLGTDP LTGEVSLSRV AISPNGDGVR DAVVPLVSFL RNAKEVVVTV
MDGDGNKRTL MTGQEFSKHY FNGVGDTLST FLEQAKWDGT INNMPVVDGK YYLEFKARVD
ESDARWQTTL ISVLVDTMGP SVDANYDALT KELTIAGNDA GGSGVAYYDV LVNRVSVLTE
GPLAADTTSY TLDSVKEGDV VTVVAYDYAG NAGKAVATGD DVIPFVTAVT PAALDSVNSR
VVTVEGYVVD DSDVAELTVA GKAVELVWDP VENHYDFVAE VVFEQDGVQS FMISASDIAG
NDISFKRSVI VDSSAPAVTV DAPLFVDGDV GTAVVKYNVS DNFNELRVYE NGSEVYRDMM
DYPLVMKAGS YAGTANVKLH DGENTFVIEA YDVAGNVVTR EVNIYRGYAE VAAFVDAGWA
AEEVGFLQRL GILSGVSEDR FGAGDAVTRA DAVQWLAASL ELDVTSDVAD PGFSDVDVAH
PAYAAIAAAK AAGIVSGNGG KFNPDAALTR AQMAKILAVA FDLDVVAVDV ELFSDVMESH
WARGYVDALF VAGITTGKAD GSFAPEAFTT RAELAVFLAR ALDDRFKD
//
