ID   A0A3R9W9U3_9ACTN        Unreviewed;       445 AA.
AC   A0A3R9W9U3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Squalene cyclase C-terminal domain-containing protein {ECO:0000259|Pfam:PF13243};
GN   ORFNames=EF918_34150 {ECO:0000313|EMBL:RSS56399.1};
OS   Streptomyces sp. WAC06614.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2487416 {ECO:0000313|EMBL:RSS56399.1, ECO:0000313|Proteomes:UP000277644};
RN   [1] {ECO:0000313|EMBL:RSS56399.1, ECO:0000313|Proteomes:UP000277644}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAC06614 {ECO:0000313|EMBL:RSS56399.1,
RC   ECO:0000313|Proteomes:UP000277644};
RA   Culp E., Yim G., Waglechner N., Wang W., Pawlowski A.C., Wright G.D.;
RT   "Unmasking the antibiotic production potential of Actinomycetes through
RT   CRISPR/Cas9 inactivate of ubiquitous gene clusters.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the terpene synthase family.
CC       {ECO:0000256|ARBA:ARBA00006333}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSS56399.1}.
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DR   EMBL; RPRY01000522; RSS56399.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3R9W9U3; -.
DR   OrthoDB; 3852853at2; -.
DR   Proteomes; UP000277644; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00688; ISOPREN_C2_like; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277644};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..445
FT                   /note="Squalene cyclase C-terminal domain-containing
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018538326"
FT   TRANSMEM        418..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          85..252
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          28..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          386..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..414
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  44472 MW;  8E3605F053B4C7C7 CRC64;
     MYVRRSAAVL AASVALCASA APAALADPSP AASAAPSAPA NQPPAAPAAP TGLYGTGDPT
     YDGVFRQSLS LLAQHSVGVR PAPAAVSWLT GQQCANGSFA AFRADPTKAC DATTMADTNA
     TAAAVQALAA LGGHQDAVTK AVDWLKSVQN EDGGWSYGPG TAMDSGTDAN STGIVIGALA
     AAGEEPDKVR SKKNVAGGTA LQWLQIRCQQ EGETGPTPSG AFAFQADKSG KLLPNADATA
     AAVLGVLGTG MAVQTPTGDA AKKDFTAVNP LSCKMGPGDG QLSADNGAKY LADTMAATGH
     HLMSAMPGAT DQPDFGNTAD AVVALAAAGY PAAAAQPLSW LQQNAAGWAK TAGPAAYAQL
     ILAARATGAD PRAFGGTDLV AALNAQGPAP QTDKPQPEQQ KNEEKKKEQK KEDSGSSIGW
     MIGAGAAAGV GIGFLLSGRR KKQQP
//