ID   A0A3R9WRU5_9ACTN        Unreviewed;       954 AA.
AC   A0A3R9WRU5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Peptide synthetase {ECO:0000313|EMBL:RSS80836.1};
GN   ORFNames=EF918_12385 {ECO:0000313|EMBL:RSS80836.1};
OS   Streptomyces sp. WAC06614.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2487416 {ECO:0000313|EMBL:RSS80836.1, ECO:0000313|Proteomes:UP000277644};
RN   [1] {ECO:0000313|EMBL:RSS80836.1, ECO:0000313|Proteomes:UP000277644}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAC06614 {ECO:0000313|EMBL:RSS80836.1,
RC   ECO:0000313|Proteomes:UP000277644};
RA   Culp E., Yim G., Waglechner N., Wang W., Pawlowski A.C., Wright G.D.;
RT   "Unmasking the antibiotic production potential of Actinomycetes through
RT   CRISPR/Cas9 inactivate of ubiquitous gene clusters.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSS80836.1}.
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DR   EMBL; RPRY01000069; RSS80836.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3R9WRU5; -.
DR   OrthoDB; 2472181at2; -.
DR   Proteomes; UP000277644; Unassembled WGS sequence.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR001031; Thioesterase.
DR   PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43767:SF10; SURFACTIN SYNTHASE SUBUNIT 1; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277644}.
FT   DOMAIN          557..635
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          640..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   954 AA;  101202 MW;  25D9053E8143D204 CRC64;
     MRPTTPPSTL SDLLLAAAER YPGSGLRHCH GAARLGHRDQ SHPELLARAR RILTGLRARG
     LRPQDKIVIV LEGSEEFLPT FWAAVLGGFV PCPVAPPSGD PAAWAERLRH VVALLDGPLV
     VTTAALAGQL PRDAAGAAVA ALEELDGPEA DELYRAAPGD TAVLMLTSGS SGAAKAAMLS
     HAALLASMAA KNGHHRLTAA DTSLNWVSFD HVAALLECHL LPLSTGSRQV HAPASAVLGD
     PLEFLRLIDR HGVTMTFTPN FLLGQINAAA GRLAASGERL DLGRLRHVVS GGEAVVVATG
     ETFLRTLEPY GLAPDALWPA FGMTETCAGS VYSRGAFPAA DRGREFAHLG TAVAGLRMRI
     VDEDGRELPD GAAGELQFHG PMLTSGYHND PGATAEAFTA DGWLRSGDLG RIDEGRLTLV
     GRSKDSVIVN GVSHYSHDVE TVLGRLDGVT AARVAAFPTR PAGSDTEQLV VAFAPDLPAG
     DEAGLHRVMS AVRSTVVMHW GFRPALVLPL AADAFPLTSL GKIQRTLMRR RLESGAYDGE
     RRAARELQVR MLGGHTAPEG PVERAIAEIY AELFGAGPDT ISATASFFDL GGTSLDILRL
     RGKVAQRLGV SGLEVVTVLT APTVRALAAR LAGRTAAAAP ATGSVTAPAP DPAPATDPAG
     APAGSGPAPY EPVVALQTGG DRTPLFCVHP GVGEVLVFVG LAAYFAGDRP FYALRARGFN
     EGEKPFVSFE EMVDTYVAAI RARQPQGPYA VAGYSYGAAV AFEIAKVLEA DGERVDFVGS
     FNLPPHIKYR MEELDFPETA AHLAAFLDLV DKEQAAALPA LLRGRPREEQ VAHLVSLAPP
     QRLAELDLDE EKFAAWAEVA DALTDLGRGY EPAGTVRSMS VFHAEPLRGT REDWLANELR
     RWDEHTTGAN RYLEVPGEHH TLMGPRHVAA FQEVLRRELD DRLAEADAIA AARR
//