ID A0A3S0A7T5_9ACTN Unreviewed; 453 AA.
AC A0A3S0A7T5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=MFS transporter {ECO:0000313|EMBL:RSR95536.1};
GN ORFNames=EF917_25330 {ECO:0000313|EMBL:RSR95536.1};
OS Streptomyces sp. WAC00469.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2487415 {ECO:0000313|EMBL:RSR95536.1, ECO:0000313|Proteomes:UP000269080};
RN [1] {ECO:0000313|EMBL:RSR95536.1, ECO:0000313|Proteomes:UP000269080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAC00469 {ECO:0000313|EMBL:RSR95536.1,
RC ECO:0000313|Proteomes:UP000269080};
RA Culp E., Yim G., Waglechner N., Wang W., Pawlowski A.C., Wright G.D.;
RT "Unmasking the antibiotic production potential of Actinomycetes through
RT CRISPR/Cas9 inactivation of ubiquitous gene clusters.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSR95536.1}.
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DR EMBL; RPRX01000130; RSR95536.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S0A7T5; -.
DR OrthoDB; 9775268at2; -.
DR Proteomes; UP000269080; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06173; MFS_MefA_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR010290; TM_effector.
DR PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR PANTHER; PTHR23513:SF11; STAPHYLOFERRIN A TRANSPORTER; 1.
DR Pfam; PF05977; MFS_3; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000269080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 103..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..423
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 47664 MW; 0A781495E55D6BB5 CRC64;
MSTGSGDNSA PAPTTHDSQT STDSPRNSSM FSSLKIRNYR LFFLGQVVSN TGTWMQRIAQ
DWLVLSLTGS SAAVGITTAL QFLPMLLFGL YGGVLVDRLP KRPTLLCTQS VMALTGLALA
GLTLSGHVQV WHVYLAAFVM GLATVLDNPA RQTFVSEMVG PQQLQNAVSL NSANFQSARL
IGPAVAGVMI TSVGTGWAFL VNGLSFAAPI TGLLLMRARE LHVVERAPRG KGQLREGLRY
VAGHPNLLWP IVLVGFIGTF GFNFPVWLSA YADDVFHAGA GAYSLFNTVM AVGSLAGALL
AARRGTARLR LLIAAAAAFG ALEIVAAVAP EYWLFALLMA PIGVFGLTVN VTANTTVQMG
TAPAMRGRVM SLFMMVFVGG TPLGAPLVGW MTDTWGARAG FAVGGAISLV AAVTIGLLLA
RAGGLRLSVG WNHGHPQVRF VPKEGREELA PAA
//
