ID A0A3S0C3D6_9ACTO Unreviewed; 884 AA.
AC A0A3S0C3D6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=EKN07_00495 {ECO:0000313|EMBL:RTE50666.1};
OS Actinobaculum sp. 352.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinobaculum.
OX NCBI_TaxID=2490946 {ECO:0000313|EMBL:RTE50666.1, ECO:0000313|Proteomes:UP000273303};
RN [1] {ECO:0000313|EMBL:RTE50666.1, ECO:0000313|Proteomes:UP000273303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=352 {ECO:0000313|EMBL:RTE50666.1,
RC ECO:0000313|Proteomes:UP000273303};
RA Zhu W.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RTE50666.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RQSN01000001; RTE50666.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S0C3D6; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000273303; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000273303}.
FT DOMAIN 90..374
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 375..660
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 24..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 111..118
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 884 AA; 95939 MW; A87DD341EF3C1D40 CRC64;
MSSTNSASRD AYLDSMERLR ARIARYQAGS DGDDPLAVGT DGDTSPSSAS SGITANGAAE
APSAPAEGST SAAGAAISPA ARARMAGILS GLNPRQREAV EHAGGPLLVV AGAGSGKTRV
LTSRIAYLIA SGRALPGQVL AITFTNKAAK EMRERLETML GGLSRAMWIS TFHSACVRIL
RAEHAALGMR STFTIYDAAD SQRLMNMVCR EEGIDHRAFP PKKLARQVSD LKNELTTPQQ
AADRASDQAG QVLAQAYAGY QQRLRQANAM DFDDLIMSTV ELLQTRPDLA EHYRRRFRHI
LVDEYQDTNH AQYVLIRTLT GTEDDPVHGE LTVVGDADQS IYAFRGATIR NIEDFEDDFP
RATTILLEQN YRSTQSILSA ANAVISHNQH RRAKNLWTDQ GDGEKLVGYV ADSEADEANF
VVEEIDRLRE TAGYRYGDVA VFYRTNAQAR AVEEMFVRSG IPYRVIGGTR FYERREIKDA
LAYLHAVVNP DDTVSLRRVL NMPKRGLGDR AEEAVASHAA RFGISFGAAL EDVAHPDARG
EVSGLTARAR SSISNFVAVL EKGRAMAAEG EAPADILDEV LDEAGYLKML RSSDDPQDES
RLENLAELHS VAAEFRTADP EGTLEQWLDQ ISLVSDSDQL ADGEYGEGET TLMTVHTAKG
LEFPAVFVTG LEDGTFPHMR SMDDPAELAE ERRLAYVALT RARQRLYLTR AATRAAWGAP
QEFPPSRFLE EIPPELVDWR REQSSQDILR SSWRGADTWG ENYGRRGSGG ASYESRFDDD
GPVFGAGKGF VPGKLGLREA STEKAGTAVL ADGPDAEDSA GSSAGSGGAD THGLAVGDDV
RHKSFGAGRI VSFEGSGKST VAKVNFRSGA TKRLMLRFAP LEKI
//