ID A0A3S0IED4_9BACL Unreviewed; 940 AA.
AC A0A3S0IED4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:RTE11106.1};
GN ORFNames=EJQ19_04030 {ECO:0000313|EMBL:RTE11106.1};
OS Paenibacillus whitsoniae.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=2496558 {ECO:0000313|EMBL:RTE11106.1, ECO:0000313|Proteomes:UP000276128};
RN [1] {ECO:0000313|EMBL:RTE11106.1, ECO:0000313|Proteomes:UP000276128}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MER 54 {ECO:0000313|EMBL:RTE11106.1,
RC ECO:0000313|Proteomes:UP000276128};
RA Seuylemezian A., Vaishampayan P.;
RT "Bacillus ochoae sp. nov., Paenibacillus whitsoniae sp. nov., Paenibacillus
RT spiritus sp. nov. Isolated from the Mars Exploration Rover during
RT spacecraft assembly.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RTE11106.1}.
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DR EMBL; RXHU01000013; RTE11106.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S0IED4; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000276128; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000276128}.
FT DOMAIN 686..702
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 612..619
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 940 AA; 103324 MW; 00B90E1C5D850185 CRC64;
MAAYTPMIQQ YLAVKAQVPD AFLFFRLGDF YEMFFEDAIN ASRELEITLT GREGGVDEKI
PMCGVPHHSA ETYMARLVEK GYKVAICEQT EDPAQAKGVV KREIVRIVTP GTVMDSKLLG
EASNNYIVSL AGDVQGYAFT ACDISTGELY ATQLQGSWEL VLDEMNVYNP SEIVTDSGLI
AKIRDSGAAW GRNLVLTEWT RADEGLLEEH FAEDSARQEL TPLSRHGVAL LLAYLKETQK
RALTHVKHIR IYEPAQYMTM DPFTRRNLEL VETVRERAKK GSLLWLLDKT VTAMGARMLR
RWIEKPLMSV ARIEERLEAV NLLYNQLIVR EDVKSALKEV YDLERLVARI SYGNANARDM
VALKHSLMQV PTLQQVCAAS GSETLRKLVA DMDDCADVMA WIASAIVDEP PVSIRDGGMI
REGYQPYLDQ LREASTNGKQ WIAELERKER EATGIKSLKI GYNKVFGYFI EVTKANMSAL
QEDRYERKQT LANAERYVTP ELKEKESLIL EAQDKMVDLE YELFTELRDR ISQHISRLQK
LAEVIATADV YQSLAAVSAA QHFKRPEIGE GFDLEIKEGR HPVVEAVIQD GSFIANDTSL
VQEEGRILLI TGPNMAGKST YMRQVAVICL MAQIGCFVPA ASARIPVTDR IFTRIGAADD
LIGGQSTFMV EMMDIQVMTE KATRQSLVII DELGRGTSTG EGMAIAQAVI EFLHDRIGCK
TLVSTHFHEL AHLEESLANL RNHCMAVKES GRQVTFLRKL IPGAASTSYG IYCAEIAGLP
QDIIQRSYVL LQGFEERAAA AAQSAAGVEP GAAHSAGAVK ERPSAAYDAG FAAGLAAASS
AGLAAEPVTA ASSEPESLAA VTAAQESAST AAAASGSAAP SAGGIQQLSL FDDEDAPPVQ
KKKLDPKSQQ VLDQLKDVDL INMTPLQALN LVYELKQKLH
//
