ID   A0A3S0ILW0_9BACI        Unreviewed;       378 AA.
AC   A0A3S0ILW0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase {ECO:0000313|EMBL:RTR35360.1};
GN   ORFNames=EKG37_05635 {ECO:0000313|EMBL:RTR35360.1};
OS   Bacillus yapensis.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=2492960 {ECO:0000313|EMBL:RTR35360.1, ECO:0000313|Proteomes:UP000271374};
RN   [1] {ECO:0000313|EMBL:RTR35360.1, ECO:0000313|Proteomes:UP000271374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XXST-01 {ECO:0000313|EMBL:RTR35360.1,
RC   ECO:0000313|Proteomes:UP000271374};
RA   Yu L., Xu X., Tang X.;
RT   "Bacillus yapensis draft genome sequence.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RTR35360.1}.
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DR   EMBL; RXNT01000003; RTR35360.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3S0ILW0; -.
DR   OrthoDB; 9803887at2; -.
DR   Proteomes; UP000271374; Unassembled WGS sequence.
DR   GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:RTR35360.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271374}.
FT   MOD_RES         195
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   378 AA;  41210 MW;  CC4D86A0DFB1A604 CRC64;
     MKRKTRLIHG GISGDPATGA VSVPIYQVST YKQEGVGGHK GFEYSRTGNP TRHALEELIK
     DIEGGHAGFA FGSGMAAITA VIMLLNSGDH VVLTDDVYGG TYRVMNKVLN RFGIESTFVD
     TSNLEEIEKA IKENTKAIYI ETPTNPLLKI TDIREAANIA KKHDLLTIVD NTFSTPYWQN
     PIELGADIVL HSATKYIGGH SDVVAGLVVV NNEKLAQDLH FVQNSTGGVL GPQDSWLLMR
     GIKTLGVRME ETEANTREIV AFLEKHSRVK KVYYPGLESH PNHEIAKKQA TGFGGMISFD
     IGSEAAADEL LRKVKYFTLA ESLGAVESLI SVPARMTHAS IPQERRAELG ITDGLVRISV
     GLEDVEDLIE DLKQGLES
//