ID A0A3S0ZXG6_ELYCH Unreviewed; 2476 AA.
AC A0A3S0ZXG6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
DE Flags: Fragment;
GN ORFNames=EGW08_014622 {ECO:0000313|EMBL:RUS77622.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS77622.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS77622.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS77622.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS77622.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS77622.1}.
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DR EMBL; RQTK01000566; RUS77622.1; -; Genomic_DNA.
DR STRING; 188477.A0A3S0ZXG6; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd17726; BRCT_PARP4_like; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 1.20.142.10; Poly(ADP-ribose) polymerase, regulatory domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR031273; PARP4.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
DR InterPro; IPR000684; RNA_pol_II_repeat_euk.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019956; Ubiquitin_dom.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46530; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR PANTHER; PTHR46530:SF1; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF13768; VWA_3; 1.
DR PRINTS; PR00348; UBIQUITIN.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00213; UBQ; 1.
DR SMART; SM00609; VIT; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF47587; Domain of poly(ADP-ribose) polymerase; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS00115; RNA_POL_II_REPEAT; 2.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
DR PROSITE; PS51468; VIT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|RuleBase:RU362114};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|RuleBase:RU362114};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 2..97
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 395..598
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT DOMAIN 635..765
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 1377..1450
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 1548..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1576..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1715..1819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1902..1982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2051..2098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2111..2163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1589..1665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1715..1799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1906..1981
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2118..2163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RUS77622.1"
SQ SEQUENCE 2476 AA; 268082 MW; AACD5117B2C6D67E CRC64;
KMQVHVFKGL QIAVDLGTSL SFKNKSELRK AITDNGGTIS YIVTRKCHFV VTSDPEKCDI
SSKCRMAVKY GLPVLKLDYI WDCLAACKLQ PYDVYVVGGK ASSLDFKSGK ISAGKMGNQT
KEKRRGFGAH FNPSSVKVWI GNDPAQPEYD EKLHEVVKYS VWTCFNSAAD CEFSYVVELH
ASSHVRPLGA DPNKCEGAQR SECFPYRVFF QCGRTISIKT GAENQCESRY TSSAEQALDV
YAMLVNRVMG KPGAQVCRSP VRGLGSSLLR KKLAESVQVQ DGCSGQVQDL VEHVWREAMT
EVTSLLGNLS SIKLDQVEKA EAILSKISSA LETSQSDEDI QNTIREFYNT LNHKNESLES
VKIQWKKWLT KKRDLCQLVK DMVSVGEMTN YESQAVVEAK YAALRCRITA LSGTQREEVQ
NLVLSSICDG SKLSVLNVFE VWRQVEDVDF RHDLKPTKLL FHSSRVENFV GILSRGLLLP
KVIVDDYGGT RSDAGMLGSG IYFASASSTS VKYSAPSNTK GTRLLLISEV ALGATKDYTE
HDTSLISAPD GYDSTHGVGR RQDNESLFEF DEYVVYKTNQ QRMRYLVEFA TDDDMPQSLD
IATQDDTYIS SDTVHNDTKN DCSLHDVLDV ANPMDKVKAG LLGSGDQEVE LKGVHIRAKL
LDLAAEVVVL QEYYNNSSHA IEAKYVFPLT EAAAVCGFEA FINGKHVVGQ VKEKEMAHKE
YKKAISEGHG AYLMDQDEET PDVFTVSVGN LPAGACVLIK ITYITELRVE DEKVSFRLPG
TVAPWKEKSA LLQTTQTELK SHATKAMRTS VQVAVEMPFD IRTLHCPTHK VKVKQTASKA
FVELAGRQKF GSGFLLLIGL AEIHVPRMWV EQHPTKAHHR ACMLTFYPEF ELEALLGGEI
TLMLDMSNSM KETQILKLAS LVLQSIPEGF KFNIVRFGSE FEELFPAPKL RSDETMEAAQ
LFVESSRMMM GNTNMYSALR PFHLLPPGDA GSPPMMRNVF LLSDGHLLEE RLVLEEAAKF
SWHTRIFTFG ISPTCNIHTL RALARVSAGA FEYFDLKTKS KWQAKVESQV VKARQPGLTS
VSVEWRQYED PLMPPVQAPR QITALFSGSQ QIVYGYVPDC TMANLRAVVG GQEVSTVVST
SELSITQGLL VHRLTARAII QDWEAGVLAR DRTDHELTKM KLKDYVIELS KEYSIVTQLT
SFVAVEKREE NEKENLPTGP SMKELLGRET VENLPYMGWT SVPEPSVESL IEELSFEDGE
EELETLNAWR AEKTGELEKL YQAQSARGGP CSLLTLQALE VIVNSYKSLG DVDKAQRMTV
QALKDASSEI DEMVATANYP TIATILTNLR GQLSENIHVS EVAGVAIPWP KEGNGIIKVK
TLTGKTCEFS CTPNMSIKQL KDLIFGHEGY PQDTQRLIYK GKQLEDGSTL GECDADFGAL
FHLVQRLRGG GGAEDLQSFR SELSDDDSYS SSMEVALADL EEDEDFGYGL FDSSEDDTYD
EVTTEISVTE KAETKGCDES FALEEDFVTL NEEGNEVYEG LQVLPKRPVK SAAPSRPDPV
PLESVTIITD NEKKKKKKKK ALDSGTAFGS AGSGESTSQP TFASAGFGDS ANQPTFGSTG
FGGSANQPTF ASAGFGDSAN QPTFGSTGFG GSANQPTFGS AGFGGSANQP TFGSTVFGGS
ANQPTFGSTV FGGSANQQTF GSTVFGGSAN QQTFGSPGFG GSANQQTFGS AVFGGSANQP
TFGSPGFGGS ANQPTFGSAG FGGSANQQTF GSPGFGGSAN QPTFGRAGFG GSANQQTFGR
AGFGAPAAQS APASSLFGTS SPQSALGPYL FGTSENMSAP TSSLFGAPDS LSAPGPALFG
APALASSFCL TPANQPLIES AIGVELYEQS KQEPMEMIMH KKSSRLQTPP PPPPPPPAAA
FAPPQSPQSP PPPPPTAFAT PQSPQSPPPP PPTAFATSQS PQPPPPPPAA AFAPPLPPPR
LATAAAVKAP PLPPPRLATA AAALAPPLPP PRLATAAAAF TPPPLPPKRL ATAAAAFTPP
LPPPRLATAA AVKAPPLPPP PQKKSLAQAS IKKTRSLDPS IFELGMTRGK GKGPGFAQGL
RASLNKEITE HQKFGSHKSS NKFPSPPKYS SESPDLSPTS PSYSPTSPSY SPTSPAYSPT
THALSLPAPS KKCHVEVSWR SEGVGDISIA RSELWAPYQA RKSIGGLVEM SSEEFMYEGS
GATLQSQQKN LLQEMQHKLV ERRWERHSKC LYIDQDKVSL ERQEIETERA TLASSDLKRP
GDVFAPGIES SPPYKKLSQE VSLFSFGIGT DLSPARVSHG VRLSVGNVAN LFKLQMENGS
WQFTEELDDL IGVKSIQCIQ VLRTSGLSSL GLTAWDEITR MLATILALFV ILRELLPQFA
DKTNPCFADI LDHLNSVPIS DCPAVLTEGL PAIVKAVKFL IVLDKKYPAL YSRLELGSSW
FNVAVNLMHP AVVAAA
//
