ID A0A3S1B7Z8_ELYCH Unreviewed; 1754 AA.
AC A0A3S1B7Z8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|SMART:SM00181};
GN ORFNames=EGW08_018025 {ECO:0000313|EMBL:RUS74219.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS74219.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS74219.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS74219.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS74219.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS74219.1}.
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DR EMBL; RQTK01000854; RUS74219.1; -; Genomic_DNA.
DR STRING; 188477.A0A3S1B7Z8; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00058; Ldl_recept_b; 12.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS51120; LDLRB; 14.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1754
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018535829"
FT TRANSMEM 1388..1408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 119..161
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 162..207
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 208..250
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 299..338
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 386..428
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 429..471
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 472..516
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 517..559
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 607..646
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 692..734
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 735..777
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 778..820
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 821..863
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 911..954
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 1004..1048
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1095..1138
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1139..1181
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1229..1268
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1448..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1706..1754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1574..1594
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1599..1626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1639..1657
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1658..1678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1754
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1294..1309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1312..1324
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1319..1337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1331..1346
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1754 AA; 195038 MW; 6BF163A67DBD887F CRC64;
MGQSSVTCTL VCVAWILSLC NGELIIFANH KDIQVVDGAS VPSSGGKPMA RNATPEILIS
NLDDATAIDF LFEENMVFWT AANMVAIKRM NIKTSRNPKT TVSKDLQSLD GLACDWVSRK
LYWSDSETNR IEVSTLDGKF RKVLYWERLD RPGPIALDPE NGYMYWTDYG ETPKIERAGM
DGNEETRTII IGEDISWPTG LALDYEMSRV FWVDVKLKSI FSCDFDGGNR QAVIEGTLKQ
PFSITVSSRN IYWTDWQRNA IHSCNKFTGS GCYIVLDKIY APMALQVYSP ARQPRGHNMC
GDSNGGCSHL CLLSPVPPYF TCACPTGVRL LSDNRTCADG AEKMLFLARR TDLRQISLDT
PDYTDVVIPI KNIIHAIALD YDSVTGYIYW TDDEVRTIQR SYINGSGQEI VTNTEVSRPE
GIAVDWIAQN LYWTDTGTDR IEVARVNGSS RKVLISDGLE EPRALCLDPA NGHMYWTDWG
ETKPMIARAY LDGTHRQEII STGVKWPNGL ALDLTEGRLY WGDAIKDRIE SANLDGTDRK
VLVSDKLPHI FGFSVLDEYI YWTDWQSRSI ERVNKWTGKN RTSIVDELPD VMGLKAAHIT
RPKSTNICAI NNGQCSHLCL YRPKPLRHVC ACPMGLELRA DGKTCIVPDA FLLFSSRSDI
RRLSLETSYN NQPIPIQGVQ KAMAIDFDIS DNRIYWTDGE LQQISQAFMN GSSLQHIIQF
GLDSPEGLAV DWVAHNIYWA DTGKDRIEVS RLDGSSRRAL VWRNLEDPRA LALDPPSGYL
YWSSWGSEPV LERANMDGTN RKVLVSKVGR IQDLTIDYID RRLYWTDLWD HSIRSSDLLG
GDIRLVAQSE IEHPMGLSQY ENFVFWTDPK RGTIERASKL DGTNRTVILR ELDGVMDILV
FHASRQAGTN ACGSYNGGCS HLCLAHPADD PSNTTHHCAC PTHYTLSGDR RTCSAPRQYL
LLSTRNSTIR LVIGGKNAVD NPEVTLPING MKNIKALDYD PVGEYIYWIE GRQKVIKRAH
DNGTMMDTVV SDADNTFQPY DIAVDPYART IYWTCNENDV INVTRIDRLK SPIGVIMQSE
GDFKPRSLVI YPEKGRMYFT NMVKPPRIEQ ALMDGTERTP LFSSALEHPQ SLTIDKHEQK
LYWADQRLNR IEIADLTGGN RRVLVDGQVG NPRGLAVYGK FLYWLSKEQN HVERIHKKTG
NQRLWVRSRL RGLSDLISVE HSTLTDWHPC HPSKAPGCSH LCFMGDDEKA QCSCPMHLML
KKDKKTCSEP PRCASHEFKC RSGSVQCIPK VWKCDSTPEC EDQSDEENCP GCGEDQFECD
SGECISQALR CDGINSCSDG SDELSCCVED QEGTCPCVDC PSGQADCSNG NPCPSKASQD
RGKTSKNYTI AFVAVGVFFV VVVLFVFVCK HKAAGVRRGS APLVVDEDIM MVKKPLNPAG
GPLLLLPGSA DSDGGQGRSL SPHSTVLLSR GKSQATGLSI GSDGSVVGGP GGPPPFYDRN
HVTGASSSSS TVTHYPHETL NPPPSPVTDR SVYTAPSGDV YVSLNSLAST AILEQQPMVT
GGSISNNLTT GNKSRRRNNH RRHHHHHHHH HHIPTQPLLP QPSLASAGNG GTSGLPATTT
PCSTDICEDS EPYHQPVNPQ HHSHHHHHHH HHHKRGSVSS SSAVPLHTST PASNKKHSSS
RTSRARKAHA KKLNYYINNS GVDYNYDSDP YPPPPTPHSH YFSDEVSCPP SPSTERSYFN
PYPPPPSPVA NSDC
//
