ID A0A3S1BPR6_ELYCH Unreviewed; 729 AA.
AC A0A3S1BPR6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Prolyl endopeptidase {ECO:0000256|RuleBase:RU368024};
DE EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
DE Flags: Fragment;
GN ORFNames=EGW08_020382 {ECO:0000313|EMBL:RUS71860.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS71860.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS71860.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS71860.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS71860.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000721};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the peptidase S9A family.
CC {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS71860.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RQTK01001149; RUS71860.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S1BPR6; -.
DR STRING; 188477.A0A3S1BPR6; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368024};
KW Protease {ECO:0000256|RuleBase:RU368024};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW Serine protease {ECO:0000256|RuleBase:RU368024}.
FT DOMAIN 38..280
FT /note="Acylamino-acid-releasing enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19283"
FT DOMAIN 512..724
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RUS71860.1"
SQ SEQUENCE 729 AA; 81265 MW; 9D2F7843172B6E51 CRC64;
EKELVSVYRE VVGYPSLTGA KVTLGGDAKN QLLTLESYWS QRDLERKERA VSLRTHTINI
TSGDVLSSSG PQEVKNELWN KMSPSGSLRA VVRVCKDKKN EDKQYVEIFD TKRKLKTIDV
QSLEKHGKII DNDGQFGTFE WSSSEGHLLY MAEKKVPVSK GFFDPKAFKD DPIGGEDAED
DLKDAKAIGK EEALVGEEFV YQESWGEQLV ERIHPVICIL DIDACTISVL ENLPENVSPG
QAMWAPDDAG VVVCAWEHEP FRLGLKHCCQ RRSALYYIDL QKVTVEILSE PERAVRFPRF
SPDMSRLIYL DTPVGGGHLQ CVRLVKVAWP SLKREVVVDI VRSAPALEFP GLFCAGMNRD
VWFEDSVHLA MSSHFRSRLA VFIINTDSGK IQRVQIDGEE GCMSLLCVTK NIVVLQCSTP
NTPAHLVFGK VEDPSDMSKT NWVYPDGRPE TLDWLSWTII PHSVPKERVN EKYPSLDYES
ILCLPKLEKS DGLPPLIVFS HGGPNTSFDS AFNDIVAFFS RCGYATVMVN YRGSLGFGQD
SVDSLLGCIG TQDVKDVESA MVEVVAKGVA DGNRIFAFGG SHGGFLSTHL IGQYPDTFKA
AATRNPVTNL VSMFSTTDIM AWIFYQAGLP FDFKSLADDT LLPKLWKASP IAYVDQVKTP
LLLMLGQEDR RVPPSQGVEF WRCLKARNVP VRMQSYPGNN HSISSVDAEA DCMINTMVWF
NKHLPGKQA
//
