ID A0A3S1H0E0_ELYCH Unreviewed; 727 AA.
AC A0A3S1H0E0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=EGW08_022496 {ECO:0000313|EMBL:RUS69738.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS69738.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS69738.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS69738.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS69738.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX15/PRP43 sub-subfamily. {ECO:0000256|ARBA:ARBA00024333}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS69738.1}.
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DR EMBL; RQTK01001588; RUS69738.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S1H0E0; -.
DR STRING; 188477.A0A3S1H0E0; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17973; DEXHc_DHX15; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044756; DHX15_DEXHc.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974}.
FT DOMAIN 81..246
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 271..451
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 727 AA; 82814 MW; 20EFF3D2F255BC93 CRC64;
MSKRRIDVGD SMSSKRNREE DGSGDKKDES SKSKSIFEQF NIPRPTLQLN PFTGLPFTAR
YYELFRKRSQ LPVWEYKERF TDMVTKHQTI VLVGETGSGK TTQIPQWCLE WVRARNPKKG
VACTQPRRVA AMSVAQRVSE EMDVCLGQEV GYSIRFEDCT SSKTLMKYMT DGMLLREAMS
DPLLEAYGII MLDEAHERTL ATDILMGLLK EVAKQRSDLK IIIMSATLDA GKFQTYFDNA
PLMSVPGRTH PVEIFYTPEP ERDYLEAAIR TVIQIHMCEE IEGDMLLFLT GQEEIDEACK
RITREVESLG KEIGDLKCIP LYSTLPPNLQ QRIFEAAPPK KANGAIGRKV VVSTNLAETS
LTIDGVVFVI DPGFAKQKVY NPRIRVESLL VTAISRASAQ QRAGRAGRTK PGKCFRLYTE
KAYKKEMQEN TYPEILRSNL GTVVLQLKKL GIDDLVHFDF MDPPAPETLM RALELLNYLA
ALDDDGEITE LGSMMAEFPL DPQLAKMVIA SCDNNCSNEV LSITAMLSVP QCFVRPMEAK
KAADEAKMRF AHIDGDHLTL LNVYHAFKQN HEDHQWCYDN FINLRSLKSA DSVRQQLARI
MDRFNLKRSS TDFTSRDYYL NIRKALVSGF FMQIAHLERT GHYLTVKDSQ VVQLHPSTVL
DHKPDWVLYD EFVLTTKNYI RTVTDVKPEW LVKMAPQYYD MSNFPMCEAK RQLERIIAKL
QSGRGGN
//
