ID A0A3S2LYF5_ORYJA Unreviewed; 1063 AA.
AC A0A3S2LYF5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Signal peptide, CUB and EGF-like domain-containing protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=OJAV_G00220750 {ECO:0000313|EMBL:RVE56399.1};
OS Oryzias javanicus (Javanese ricefish) (Aplocheilus javanicus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=123683 {ECO:0000313|EMBL:RVE56399.1, ECO:0000313|Proteomes:UP000283210};
RN [1] {ECO:0000313|EMBL:RVE56399.1, ECO:0000313|Proteomes:UP000283210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS831 {ECO:0000313|EMBL:RVE56399.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RVE56399.1};
RA Lopez-Roques C., Donnadieu C., Bouchez O., Klopp C., Cabau C., Zahm M.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RVE56399.1, ECO:0000313|Proteomes:UP000283210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS831 {ECO:0000313|EMBL:RVE56399.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RVE56399.1};
RA Herpin A., Takehana Y., Naruse K., Ansai S., Kawaguchi M.;
RT "A chromosome length genome reference of the Java medaka (oryzias
RT javanicus).";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CM012459; RVE56399.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S2LYF5; -.
DR Ensembl; ENSOJAT00000011726; ENSOJAP00000010956; ENSOJAG00000004509.
DR OMA; YQDVEGQ; -.
DR Proteomes; UP000283210; Chromosome 23.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000283210};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 74..114
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 157..193
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 353..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 394..432
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 874..986
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 398..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1063 AA; 117345 MW; C3A4D7B079ED6746 CRC64;
MHAHAPCLPL THARTHTQPR APSCSPDAVR GAARNPRIAQ QSAAWGAPVF SRDACLFLLL
INTCGLMGNV GPADVDECAE SSDDCHIDAL CQNTAKSYNC ICKPGYKGDG KQCEDTDECD
NDYNGGCVHE CINIPGNYRC TCYDGFMLAH DGHNCLDVDE CLDNNGGCQQ VCVNTMGSYE
CQCTEGFFLS DNQHTCIHRS DDGMNCMNKD HGCAHICREA PGKGGVTCEC RPGFELAKNQ
KDCTLTCHYG NGGCQHTCDD TDTGPVCGCH QKYALHSDSK TCIEKDEAAI ESSEFNATSV
ADVDKRVKRR LLMETCAVNN GGCDRTCKDT ATGVRCSCPV GFTLQSDGKT CKDIDECQEN
NGGCDHFCRN TVGSFECSCQ KGHKLLTDER TCQDIDECSF ERTCDHTCIN YPGSFQCLCK
KGYVLYGLTH CGDIDECSIN NGSCEYGCIN TQGSYECLCP LGMKLHWNKK DCIEAVKCLP
NGKPAPRAQL TCTKSAGAEV CSLSCPSNAL FLADSENSYT LSCGVPIQPG RPLQKRNVTS
TLPTCADTLA PPIKHKTRFK IKDAKCHLRP RNKEKHREIS KQIVSGGQFP CTDDCQVTFV
NLKCDSSKRR RRGRKSPSKE VSLITAEFEM EMNEEEASDV CNVDCVRAKM KVKLQNAMRT
LRKSINKQQF YIQFSGTEYE VAQKPSRITD GAEICSTGQV FRDEKCVSCG VGTFYSGEQE
QCVPCPPGTY QDTEGQLSCE PCPSTDGQGI VGAKNVSQCG GQCPAGQFSS DGFHPCQPCP
QGTYQPEPGR VLCFRCGGGL MTKNEGSVSF RDCEAKVHCA PGHYYNSTTH RCIRCQAGTY
QSEFGQNYCI TCPGNTTTDF DGATNVSHCK NQLCGGELGE FTGYIESPNY PGDYPSNVDC
VWTINPPHKR RILIVVPEIF LPIEDDCGDV LVMRKSALPT SITTYETCQT YERPIAFTSR
SRKLWIQFKS NEVNSGKGFQ VPYVTYDEDY QKLIEDIVRD GRLYASENHQ EILKDKKLIK
ALFDVLAHPQ NYFRYTAAES KEMFPRSFIK LLRSKVTRFL QPY
//
