ID A0A3S2M5C3_ORYJA Unreviewed; 1065 AA.
AC A0A3S2M5C3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=I/LWEQ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=OJAV_G00089070 {ECO:0000313|EMBL:RVE68242.1};
OS Oryzias javanicus (Javanese ricefish) (Aplocheilus javanicus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=123683 {ECO:0000313|EMBL:RVE68242.1, ECO:0000313|Proteomes:UP000283210};
RN [1] {ECO:0000313|EMBL:RVE68242.1, ECO:0000313|Proteomes:UP000283210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS831 {ECO:0000313|EMBL:RVE68242.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RVE68242.1};
RA Lopez-Roques C., Donnadieu C., Bouchez O., Klopp C., Cabau C., Zahm M.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RVE68242.1, ECO:0000313|Proteomes:UP000283210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS831 {ECO:0000313|EMBL:RVE68242.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RVE68242.1};
RA Herpin A., Takehana Y., Naruse K., Ansai S., Kawaguchi M.;
RT "A chromosome length genome reference of the Java medaka (oryzias
RT javanicus).";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
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DR EMBL; CM012445; RVE68242.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S2M5C3; -.
DR Ensembl; ENSOJAT00000034449; ENSOJAP00000032329; ENSOJAG00000016147.
DR OMA; NREMSDL; -.
DR Proteomes; UP000283210; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.250.920; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF16515; HIP1_clath_bdg; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000283210}.
FT DOMAIN 19..147
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 773..1014
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 564..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 973..1009
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 571..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 120563 MW; 8B3CF1E888D7952E CRC64;
MNRSTRVKTR RTEANLGAER DHFEKQQLSS MGKAINSSEM PVKEKHARRI ILGTHREKGA
HTFWSYALGF PLNDNSILCW KFCHVLHKVL RDGHRNVLQD CMRHHGSLVE VGKLWSQLHD
RYGQLVALYT KLLCTKLEFH VKHPKIPPNL EVTDEVLERT AGTDVSDVFQ LTVEVFDYMD
AELRLADTVI RQLNTSIAVS SLTSGQCRLA PLIQVIQDCS QLYHFNVKLL FKLHACLPAD
TLQGHRDRFH EQFRSLKSFF NKTRDMIYFK RLIQIPKLPD SPPNFLHAAA LAKHVKPVVV
IPADEDGEQQ DDDDDDPEPL IDVSDSPASI VQAQPQVDIF DQTFGPPNGG FDDRDLQIDS
LKTELDFLKT ELEKVKSEAQ RYVTQLKSQI NSLEAELEEQ RVQKQRALVE NEQLRMELET
TLRRNIEHES VQVSYIEAEK RAQATEQRYN KLKEKHTELV SSHAELLRKS ADTVKMLSAT
QQTQEEVERT KHQLSFEIER IKQEAEMKLE EQKFELERVK RELEEKMTEV TRMKATMQNT
QKSSEQITSS MTALQAEKER LMRSVSEKEA ELSTLRQTAQ VQQSSLQLER DKSSRELVEL
QGKLKEKASQ EEKMKQKLLD EQFALLQGTI TEAENIIQDA VTKLDDPLHI RCTSSPDYLI
NRAEATLGSI DKMKKGHADY LKNMADAGGL LRSLTQFSHL AADTIVNGSA TAHQAPTDQA
DRLTSNCRGC ATQSLQFLKD LKSKTSLQRA DPASIRVIVQ KILKLGQELR PKGMDIRQEE
LGDLVDKEMA ATSAAIEEAV RRIDEMMKQA QKDTSGVKLE VNERILNNCT GLMKAIRMLV
KASTDLQKEI VESGRGAATI KEFYARNSRW TEGLISAAKA VGWGATEMVE SADKVVLHTG
KYEELIVCSH EIAASTAQLV AASKVKADRH SQKLPVLQQA SRHVNEMAAN LVASTKSGRE
HLEDKDPMDF SGMSLIKLRK EEMESQVKVL ELETMLENER QRLGDLRKKH YDLAGVPVEQ
APEGNGELLS LDNPVTMSPK PSKPALMKKP PLSQKPNIAP KVVFK
//
