ID A0A3S2PF48_ORYJA Unreviewed; 908 AA.
AC A0A3S2PF48;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN ORFNames=OJAV_G00037470 {ECO:0000313|EMBL:RVE74070.1};
OS Oryzias javanicus (Javanese ricefish) (Aplocheilus javanicus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=123683 {ECO:0000313|EMBL:RVE74070.1, ECO:0000313|Proteomes:UP000283210};
RN [1] {ECO:0000313|EMBL:RVE74070.1, ECO:0000313|Proteomes:UP000283210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS831 {ECO:0000313|EMBL:RVE74070.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RVE74070.1};
RA Lopez-Roques C., Donnadieu C., Bouchez O., Klopp C., Cabau C., Zahm M.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RVE74070.1, ECO:0000313|Proteomes:UP000283210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS831 {ECO:0000313|EMBL:RVE74070.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RVE74070.1};
RA Herpin A., Takehana Y., Naruse K., Ansai S., Kawaguchi M.;
RT "A chromosome length genome reference of the Java medaka (oryzias
RT javanicus).";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00034036,
CC ECO:0000256|RuleBase:RU362033};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IV subfamily. {ECO:0000256|ARBA:ARBA00008109,
CC ECO:0000256|RuleBase:RU362033}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362033}.
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DR EMBL; CM012440; RVE74070.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S2PF48; -.
DR Proteomes; UP000283210; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006539; P-type_ATPase_IV.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR24092:SF81; PHOSPHOLIPID-TRANSPORTING ATPASE VA; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362033};
KW Magnesium {ECO:0000256|RuleBase:RU362033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362033};
KW Reference proteome {ECO:0000313|Proteomes:UP000283210};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362033}.
FT TRANSMEM 613..637
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 644..665
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 671..695
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 716..736
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT DOMAIN 501..746
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
FT REGION 67..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 101119 MW; 39D9C57414004CBE CRC64;
MRLHSQPVSQ LPSDLSDIFD FFIALTVCNT VVVSSPNQPR QKVRMRFELK SPVKTIEDFI
KRFTPSRLTS GSNNSSSSSL NRSSNKGGSS MLSSPSAEST LTKLNEEQSS GGLEHAFSPA
PPSYEEKAFC TPEEGELRYE AESPDEAALV YAARAYKCSL VGRLPDQVTV ELPHLGKLNF
ELLHTLGFDS TRKRMSVVVR HPLTDQITVY TKGADSVIME LIRPPNTGNS KGRRQKKILC
RTQNYLNLYA ADGLRTLCIA KKVLSKEEYA RWLQHHLEAE TAIQRREELL FESALRLETN
LQLLGATGIE DRLQDGVPET IASLRKAGLQ IWVLTGDKQE TAVNIAYACK LLDPEEELLT
LNADSKEACK LLLEESLHYI QAKFLCSSGD VSSFEIYPPA PPSSHAASFS VHQLGLVIDG
RTLAYALDSS LEDKFLAVAR SCRSVLCCRS TPLQKSMVVK LVRNKLKVMT LAIGDGANDV
SMIQVADVGV GISGQEGMQA VMASDFALPR FRYLQKLLLV HGHWCYSRLA NMILYFFYKN
AMFVALIFWY QFYCGFSGSA MIDQWYLIFF NLMFSSFPQL ISGTLDKDVS AETLQQLPQL
YTSGQNSEEY KPYMFWMNMI DAFYQSLVCF FIPYFTYTDS DVDLFTWGTP ITAIALLTIL
LHLSIETKTW TWMNCLSITF SIALFFTVAL CYNASCPTCY PPSNPYWTIQ RLLQDPVFYL
LCTITPVAAL LPRYFYRACH STLFPNPVQV GRQLDKLPAD TRRNILSLSR VKMGSWLSPR
PPSLPVGKPQ SCVQKDQRSK LAPAQRGDAE SVQQGAGPES CTKNDPLLSE ELQPASTKDP
SDSGPCSGMT STPVVAQMDR VQLNLPPSRT SPCVAYVRSS EAPLSREQTP PCSHGTGQGA
EPALYTVL
//
