ID A0A3S3MSV5_9MAGN Unreviewed; 3773 AA.
AC A0A3S3MSV5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=CKAN_00252700 {ECO:0000313|EMBL:RWR74208.1};
OS Cinnamomum micranthum f. kanehirae.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Magnoliidae; Laurales; Lauraceae; Cinnamomum.
OX NCBI_TaxID=337451 {ECO:0000313|EMBL:RWR74208.1, ECO:0000313|Proteomes:UP000283530};
RN [1] {ECO:0000313|EMBL:RWR74208.1, ECO:0000313|Proteomes:UP000283530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chaw 1501 {ECO:0000313|Proteomes:UP000283530};
RC TISSUE=Young leaves {ECO:0000313|EMBL:RWR74208.1};
RX PubMed=30626928; DOI=10.1038/s41477-018-0337-0;
RA Chaw S.M., Liu Y.C., Wu Y.W., Wang H.Y., Lin C.I., Wu C.S., Ke H.M.,
RA Chang L.Y., Hsu C.Y., Yang H.T., Sudianto E., Hsu M.H., Wu K.P., Wang L.N.,
RA Leebens-Mack J.H., Tsai I.J.;
RT "Stout camphor tree genome fills gaps in understanding of flowering plant
RT genome evolution.";
RL Nat. Plants 5:63-73(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWR74208.1}.
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DR EMBL; QPKB01000001; RWR74208.1; -; Genomic_DNA.
DR STRING; 337451.A0A3S3MSV5; -.
DR Proteomes; UP000283530; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05170; PIKKc_SMG1; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR031559; SMG1.
DR InterPro; IPR039414; SMG1_PIKKc.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RWR74208.1};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000283530};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1191..1778
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1993..2333
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3741..3773
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3561..3612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3624..3646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3562..3594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3628..3642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3773 AA; 418675 MW; A48BF33C2182E61D CRC64;
MQGLHHHQQQ QLAALLSVAL PKDDSSTSED DDSSRLAALN SLHRAILYPP NSLLVSHSSS
FLSQGLSQLL SDKSFSVRQL AAIAYGALCS VVCSSPLASN GRQNHAITGA VVDRFISWAL
PLIRDVTVGN GAAELALAGL REFLNIGDTS RLEVYVLPIL EACKELLEDE RTSLNLLHQL
LGILTLISVK FGQCFLPHFI DIVDLLLGWA LVPDLSESDR STIMDSFLQF QKHWLSNLQF
SMGLLSKFLG DMEALVQDGS VGTPQQFRRL LALLSCFLTV LQVTASGMLE MNLLEQISEP
LLKMLPQLLV CLSTVGKKFG WSKWAKESLR CLILLAEISC EKFSTFYLMA VEILFHSLSE
DSSTSSLGFG NIPSFQVHGV LKANMQLLSL QKLSLLPSSV KKILQFSSPL SQLRLHPNHL
VAGSSAATYL FLLQHKSDGV VKQAIFSLTE ELEFLKDMIG KICGGQNQVD SQCNLDLGSG
KCYSDLELFA LVKFDLKILL SCVCSRADGS LVDQMDVATP HYERSVMLAS FIFEKLNPFE
SPIQGDAEMQ LHVLKTLHKF SEVEFSTKCA ITKLVQKTNS LDIDSELQKQ ATSENMYSNL
VIEYLRKYSM YIVRALNALP LAVKLEGLEW VHSFCEAVIA MKLDSSLIHN SCEPCKFASI
SNTLLFSVLE AASDREFKVR SHVASILELL LQAKLIHPGH FYSVTTVVLD KLGDPDTSIK
NAFVRLLSIA LPITVYACGA FEDDEVGAPC GVGSIGFKNR AYMQWRQVFA LNQQPQQFQS
QQLVSVLSYI SQRWKVPLSP WIQRLVYSCH YKKDLLSSQQ EETGNLGANG LWVDVKVVGT
MLDKVCPVNN VAAAWWAIHE AARHCINMRL RTNLGGPTQT FAALERMLLD IAHVLQLDTE
QNEGKLNVGA ARVHLLPMRF MLDFVEALKK NVYNAYEGSS VLPCVGRQSS LFFRANKKVC
EEWFARICEP MMNAGLAMQC HAATVHYCAI RLQDLQSLVA LALKDKPRTQ VAEYLHNLRA
RYAGDVMRIL RHMALALCRS REPESLVGLQ KWVMVTFSSL FVEDTQLIIA QPGSSFAFSW
ITGLVYQAHG QYEKAAAHFC HLLQSEEALN SMGSEGVQFA IARVIESYTA LSDWKSLETW
LLELQALRSK HAGKSYSGAL TTTGNEINAI HALARFDEGD MQAAWGFLDL TPKSSSELTL
DPKLALQRSE QMLLQAMLRR GVGKMDKVHK EIENAKLMLE ETLSVLSLDG LTEAAAYATQ
LHCIFAFEES CKNNGQDEPK QLSAIVSSLH QVLQYPITKV HQDCALWMKV LRVYRTVLPT
SLITLQLFQK LIGLARKQKN FMMAHRLNHF LRTHLVEFHE GKYTELFSKN LQYESILLAY
AEDKYEDALT SLWSLVRSYM MSPSLTASDA NNILKAKSCL KLSTWLSQKH LYRNVENVFY
QMQGDFVDFR TPDSASVSRS RISAPDLSCN LILEEIVGTA TKLSTRFCPV MGKSWLSYAS
WCYNQARGSI TALNTIVHSL SPILHPEVLP DRFQLKAEEV SRVEAIITKL FHRSIDVRSA
SDVGEEQIIW PGSDEYLKNE TSLKAMVQQT VYLIQEAAAA PGVEDCDGEF PSAVLTSQLQ
MSFLHANMGI ENADIESSVN ELVDIWWSLR RRRVSLFGHA AHGYLQFLTH ASFKLQDRYL
ASSDLDSVKQ KTGNCTLRAT LYILHILLNY GVELRDILEP GLATTPLLPW QEITPQLFAR
LSSHPSHVVR KQLEALLMML AKSSPWSIVY PTLVDVNACE GEPSEELQHI MGCLGKLYPK
LIQDVQLVIN ELGVVTVLWE EQWLSTLQDL HTDVIRRINM LKEEAARIAE NVTLSQSEKN
KINAAKYSAM MAPIVVALER RLASTSRKPE TAHETWFHTE YGEQLKSAIL AFKTAPLSAA
ALGDVWRPFD AIAASLAAYQ RKSLISLSDV APQLAALSYS EVPMPGLEKQ ISIPDSTAGP
STDLQGIVTI SSFSEKVTVL STKTKPKKLV ILGSDGQKYT YLLKGREDLR LDARIMQLLQ
AVNGFMHSHA DTRSRSIAIR YYSVTPISGR AGLIQWVDNV ISIYSVFKSW QNRVQLAQLS
AVGAGNMTNA VPPIPRPSDM FYGKIIPALK EKGIRRVISR RDWPHDVKRK VLLDLMKDTP
RQLLHQEIWC ASEGFKAFSS KLKRFSGSVA AMSMVGHVLG LGDRHLDNIL MDFQSGDVVH
IDYNVCFDKG QRLKIPEIVP FRLTQTIEAA LGLTGIEGTY RANCEAVVGV LRKNKDILLM
LLEVFVWDPL VEWTRGDGHD EAAIGGEERK GMELAVSLSL FASRVQEIRV PLQEHHDLLL
ATLPAAESAL ESFLDVLNQY EVVSALFYHA DQERSNLLLR ETSAKSIVAE ATSNSEKMRT
SFEVQAQEFT QAKAAAAEIA KEAAMWIDQH GRVIDALRSG SIPEVQACLK LSDMEEALSL
ISAVVVAGVP LTVVPEPTQA QCHDLDREVS QLIVELDGGL SCALQALQTY ALALQRVLPL
NYITTSPVHG WTQILQLSLN SLSSDTLAIA RRQAAELIAK AQGGSLESVK QRHEDLGLQI
ETYVTKTEKV KEECSDLVNS IGTDNEAKSK DRLLSAFTKY MQSAGYLRKE DYGSKDFKAQ
GEVGEKKAKV LSVLHIATGS LYKEVRSKVL DILSNSSRRI GVMPGEDSSL QISITSFNEF
EEQIEKCVLV SDFVNEIQQL IGMDIPIIST ETDNIQYSFG GNWASIFHAS ILSCRILIGQ
MVEVVLPELL SSVVSYNSEV MDTFGSLSQI RGSIDTALER LVEVQLERAS LTELEQNYFV
KVGLITEQQL ALEEAAMKGR DHLSWEEAEE LATQEEACRA QLDQLHQTWN QKDKRTSSLI
KKEANLKNAL VSAEQQFLSL VSVEQGADPR ITRSKVLLAT LARPFSKLES IDQALSPSGA
YDSYSSGSNF NMADFFSSGF SLSESIWKCA GLLSNHAFFI WKICTIDSFL DSCIHGMSST
LDHNLGFDQL YNILKKKLEI QLQKHLDQYL RERVAPALLV WLESESEHLK QLTEATKDFV
SDQLKRDGAA VRKVQRALDE YCTAHETARA ARSAVSLLER QVCELTESLR KTSLEMVQME
WLHDISLPYI HKKHIIPHDF LSDDKLTPTI LNLNRPKLLE NIQSSISAIA GSLEGLQACE
RTSLSAEGQL ERAMGWACAG TSGTGITSVK NSGIPSAFHD HLMKRRQLLW ASSGQASDIL
KICTSLLEFE ASRDGLFQLP GDVSAGRTTS DGRSWQQAYL NALTRLDITY HSFTRAEQEW
KVAQSSMEAA ASGLFSATNE LCIASVKAKS ASGDLQGTLR GMRDLAYEAS VALSAFGHVS
RGHTALTLEC GSMLEEVLAI TEGLHDVYTL GKDAAAVHAS LMEDLSKVNM ILLPLESMLS
TDVTALADAI ARERESKMEI SPIHGQALYQ SYFLRLKEAC HPLRPLVASV TSSVKELHAT
VTRLARTASI HAGNLHKALE GLGESQVVRS QEIGLSRPEL GDDAVLFNKN SPFSDDDRQG
VSEVMGLDEF SLQDEGWVSP PDCIYTSSQG SSSTSTGLSR SDNSSSQASA AEQLSEGGNA
EGAVGISNSV PFTDTDVQES SIAENLESQY VEDRKGDNIS DCSKHNPSEQ FQALSVSNGG
TITHSDTRHH MEKEIAEKVT SFDGRNEASI LNRVKGLGGN HDDPSYMDSV NRIARGKNPY
ALSVLRRVEM KLDGRDIEEN RQMNISEQVD HLLKQATSID NLCNMYEGWT PWI
//
