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Database: UniProt
Entry: A0A3S3NY50_9ACAR
LinkDB: A0A3S3NY50_9ACAR
Original site: A0A3S3NY50_9ACAR 
ID   A0A3S3NY50_9ACAR        Unreviewed;       517 AA.
AC   A0A3S3NY50;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN   ORFNames=B4U79_05134 {ECO:0000313|EMBL:RWS08356.1}, B4U79_08858
GN   {ECO:0000313|EMBL:RWS08233.1};
OS   Dinothrombium tinctorium.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC   Trombidioidea; Trombidiidae; Dinothrombium.
OX   NCBI_TaxID=1965070 {ECO:0000313|EMBL:RWS08233.1, ECO:0000313|Proteomes:UP000285301};
RN   [1] {ECO:0000313|EMBL:RWS08233.1, ECO:0000313|Proteomes:UP000285301}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UoL-WK {ECO:0000313|EMBL:RWS08233.1};
RA   Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA   Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT   "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT   transferred genes associated with secondary metabolism.";
RL   Gigascience 0:0-0(2018).
RN   [2] {ECO:0000313|EMBL:RWS08233.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UoL-WK {ECO:0000313|EMBL:RWS08233.1};
RA   Dong X.;
RT   "Trombidioid mite genomics.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436,
CC         ECO:0000256|RuleBase:RU003431};
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RWS08233.1}.
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DR   EMBL; NCKU01003071; RWS08233.1; -; Genomic_DNA.
DR   EMBL; NCKU01003008; RWS08356.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3S3NY50; -.
DR   STRING; 1965070.A0A3S3NY50; -.
DR   Proteomes; UP000285301; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0007635; P:chemosensory behavior; IEA:UniProt.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProt.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0010038; P:response to metal ion; IEA:UniProt.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF300; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000313|EMBL:RWS08233.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000285301};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          1..257
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          337..467
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   517 AA;  58898 MW;  EB74B95354B822C9 CRC64;
     MRETSHENLT RFVGACIDGP IAIIEEYCPK GSLRDVLANS SLNLDWIFRY SLISDIVSGL
     HFLHYSDHIF HGRLKSTNCL VDSRFCVKIS DFGLRELRGI NIFHRNVASD IEMTAATSST
     SITALSIDFS GFQRESDDVY APLYVSPDLI SVRCKCLKSK NKTKICSECY DRFQKGDVYS
     FAIILQEIIT RKEPFYPYSA ELNIPDIVSK ILSEDIRPIV SKDKCSIDLH CLMTRCWARD
     ADYRPDFGAI KRDMRTLAKS ASVKEDLIAN ATLTEKLLQR MEHYANDLES IVEQRTKELN
     EEKKKSEELL YQILPRVVAN QLKMGESVVP DYFDSVSIYF SDIVGFTTIC SESTPMQVVD
     LLNDLYTCFD SIISDFDVYK VETIGDAYMV VSGVPERNGN EHVRQIARMA LRIRECVEKF
     EIRHRENEKL MIRIGIHTGP CCAGVVGHKR PRYCLFGDTV NTASRMESTG EALKIHISES
     SKRCLDVFGT FQLTQRGIIN IKGKGLMNTY WLINEIL
//
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