ID A0A3S3R0D3_9ACAR Unreviewed; 1202 AA.
AC A0A3S3R0D3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Histone-lysine N-methyltransferase EHMT2-like protein {ECO:0000313|EMBL:RWS16657.1};
GN ORFNames=B4U79_09382 {ECO:0000313|EMBL:RWS16657.1};
OS Dinothrombium tinctorium.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombidioidea; Trombidiidae; Dinothrombium.
OX NCBI_TaxID=1965070 {ECO:0000313|EMBL:RWS16657.1, ECO:0000313|Proteomes:UP000285301};
RN [1] {ECO:0000313|EMBL:RWS16657.1, ECO:0000313|Proteomes:UP000285301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-WK {ECO:0000313|EMBL:RWS16657.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Target cell membrane {ECO:0000256|ARBA:ARBA00004175}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS16657.1}.
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DR EMBL; NCKU01000194; RWS16657.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S3R0D3; -.
DR STRING; 1965070.A0A3S3R0D3; -.
DR Proteomes; UP000285301; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0044231; C:host cell presynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10543; SET_EHMT; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF4; G9A, ISOFORM B; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Membrane {ECO:0000256|ARBA:ARBA00023298};
KW Methyltransferase {ECO:0000313|EMBL:RWS16657.1};
KW Neurotoxin {ECO:0000256|ARBA:ARBA00022699};
KW Presynaptic neurotoxin {ECO:0000256|ARBA:ARBA00023028};
KW Reference proteome {ECO:0000313|Proteomes:UP000285301};
KW Target cell membrane {ECO:0000256|ARBA:ARBA00022537};
KW Target membrane {ECO:0000256|ARBA:ARBA00023298};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Transferase {ECO:0000313|EMBL:RWS16657.1}.
FT REPEAT 686..718
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 719..751
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 752..785
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 786..818
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 819..851
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 852..884
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 974..1037
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1031..1150
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 25..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1202 AA; 131292 MW; 4C80D5A74B181704 CRC64;
MSLVLPSEDE KRGVPSSVDA NVSAVSGEFG STSQQSTADS LSTSKSVCDM LQDTLRNMPN
KGSARKGFAR SVAPSSAQHE AQAKFKPDRP ASSSSAVAST AAGAVTGIVV APSAAELAAS
AVVTGARSHN RARKSFANDQ HSSGAKAVDN AAPGNITVSA SSLPSSSHDE KNENHSSAPS
SLSGVLSGKK RKRYYKGATY NLFLSKKVKK RTAQQRVKTK NDNGSNAGTD TLGEESNQSF
TAGTGSEVES ISSNDENNED SCDKPADQEV VENGEQVNGD VSADNADKKD VEMTDMAGVN
NFAPDLGAEN NEPIDEQNVQ LLQSAAEQSE SLTEERGENL ECSGINVPQA ITYPLPKRSA
GSSQSVTKGG SSSAASVNQN ESNSAKSNDQ KILLRISSTG SVQSASSLIS SSYNGGGDQA
IKFFVMNDPK NTAPFGTCLC SEKPIANKNE TTKGKPLFCQ AIDSFDGKLI GCCNQARLTS
LFRASKRVPY RVFCEVHLAR LRRHHCCPGC GVFCSQGEFL ECFCIKKQVH LFHKSCQIVQ
GIGPNKQHCP HCNNVSDLRC VRLEMNGAIN NVYYLSQNPI LKTPRAKITL CKLKELPALT
GPMDDPGVEY IIPETKKILS LAGLPLGPSR KQLENLLTAL SVEKQSPSIR FTNKNFYAVS
KTGEVDKVLG LLAQGFDPNY TFEENDNETP LHTAAAAGHL VIVHLLIQAG ASPNVLNKNM
DTPLTLAVIN KHPAVVKYLI KAGAAPDIRA EDGMTALHLA SKNGSFESVF HIINAGKMNI
NLQDDGGWTP LVWATEHKHL GIVKLLISKG SDPNILDDEE NSGLHWAAYS GDVNIAYIYI
EMGVDVNAIN IHGDTPLHVA ARRDNYECVV LLLSRGADLT LLNKNNESPL MCCVKNSQSA
MALKINCELR RFASIRKLNS DRLLHRDIAK GKEYYQIPIV NGVDNEPIPV DFMYVIENCE
TSPINIDRVI TSLQSCKCED DCTSDSCICA AISFRCWYDR DGKLVPEFNL MDPPMIFECN
RACSCWKSCY NRVVQFGVRT QSKGWGVRPL KDIPKGTFVC EYIGEIITDS EADRREDDSY
LFDLDNRDGE TYCLDARFYG NVSRFINHAC SPNLTPVKVF VDHQDLSYPR IALFANRDIK
AFEELGFDYG EKFWVIKYRW FTCDCGFSEC KYSKETIGLT LENYYKRIRE EQTQDVSAMQ
DS
//
