ID   A0A3S4B6Y8_9PEZI        Unreviewed;       806 AA.
AC   A0A3S4B6Y8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=cysteine--tRNA ligase {ECO:0000256|ARBA:ARBA00012832};
DE            EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE   AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN   ORFNames=TT172_LOCUS5824 {ECO:0000313|EMBL:SPQ23405.1};
OS   Thermothielavioides terrestris.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Thermothielavioides.
OX   NCBI_TaxID=2587410 {ECO:0000313|EMBL:SPQ23405.1, ECO:0000313|Proteomes:UP000289323};
RN   [1] {ECO:0000313|EMBL:SPQ23405.1, ECO:0000313|Proteomes:UP000289323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Huttner S., Dainat J.;
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; OUUZ01000010; SPQ23405.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3S4B6Y8; -.
DR   Proteomes; UP000289323; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:InterPro.
DR   Gene3D; 1.20.120.1910; Cysteine-tRNA ligase, C-terminal anti-codon recognition domain; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   HAMAP; MF_00041; Cys_tRNA_synth; 1.
DR   InterPro; IPR015803; Cys-tRNA-ligase.
DR   InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00435; cysS; 1.
DR   PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF01406; tRNA-synt_1e; 1.
DR   PRINTS; PR00983; TRNASYNTHCYS.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          18..452
FT                   /note="tRNA synthetases class I catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01406"
FT   REGION          287..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          480..510
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          708..742
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   806 AA;  89274 MW;  D5F3797824EB03E4 CRC64;
     MASITVHNSL KPGPPVPFVP REEGKVSWYA CGPTTYDLSH LGHARNYVST DIIRRILMHH
     FGFKVNFVMN YTDIDDKIII KARRKRLLEL EKEKPYTAEQ VRELVFKAFQ AYAASNLPLL
     TGADLPALDE HSYLQRRDAA YGSVLAGGTL SGEGKPGDAE AKVKMHLSNM DSAAKSLREG
     SGFDGAEEVL LPYLDSLYKE TIDTSDQTIF TDLTQAMEKA FNDDMAALNV LPPDAVTRVT
     EYVPQIVAFV QKIIDKGFAY EANGSVYFDI AAFEKAGNTY ARLRPESRND KALQEEGEGS
     LSKSLEGKKR PGDFALWKKS KPGEPYWPSP WGAGRPGWHI ECSVMASDKL GQQMDIHSGG
     IDLAFPHHDN ELAQSEAYFH ESGKGEHTWV NYFLHMGHLS IAGSKMSKSL KNFQTIQDAL
     ATTYTARNMR IVFLMGRWND GVEISQDMRK QADNWENTVD NFFTNIKAKL AAAGPAVDGI
     KDLSLEDSKA RGLIEELEQA KKDVDAALRN SFDTPGAMQV ILRLVRDANI YMNDKSGEPS
     LQALEAVARW VTKIVGIFGL DASAQPPYDG LGWAAAGAAS TANLDPRTAV QPYATAYAKV
     KADVQALNLS EASVQNLLDQ QNPEAEFVEL EKSGERDLEK LALPYLRATS RLRDELRAIA
     AGLEPQAKKA VLALSDRIRD YDLTDLGVQL DDQADKPSLI KFVPAAKLIA AREEKAALLA
     EKARQKEEAR KAREKAEEEK WAKAKVPPQE MFKGDAKYLE WDADGLPTKL ADGSEVPKSQ
     AKKLKKDWDR QKKLHDEYLA KFGASA
//