ID A0A3S4PLR2_9MAGN Unreviewed; 449 AA.
AC A0A3S4PLR2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=phosphoribosylglycinamide formyltransferase 1 {ECO:0000256|ARBA:ARBA00012254};
DE EC=2.1.2.2 {ECO:0000256|ARBA:ARBA00012254};
DE AltName: Full=5'-phosphoribosylglycinamide transformylase {ECO:0000256|ARBA:ARBA00041682};
DE AltName: Full=GAR transformylase {ECO:0000256|ARBA:ARBA00041324};
GN ORFNames=CKAN_02130800 {ECO:0000313|EMBL:RWR92108.1};
OS Cinnamomum micranthum f. kanehirae.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Magnoliidae; Laurales; Lauraceae; Cinnamomum.
OX NCBI_TaxID=337451 {ECO:0000313|EMBL:RWR92108.1, ECO:0000313|Proteomes:UP000283530};
RN [1] {ECO:0000313|EMBL:RWR92108.1, ECO:0000313|Proteomes:UP000283530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chaw 1501 {ECO:0000313|Proteomes:UP000283530};
RC TISSUE=Young leaves {ECO:0000313|EMBL:RWR92108.1};
RX PubMed=30626928; DOI=10.1038/s41477-018-0337-0;
RA Chaw S.M., Liu Y.C., Wu Y.W., Wang H.Y., Lin C.I., Wu C.S., Ke H.M.,
RA Chang L.Y., Hsu C.Y., Yang H.T., Sudianto E., Hsu M.H., Wu K.P., Wang L.N.,
RA Leebens-Mack J.H., Tsai I.J.;
RT "Stout camphor tree genome fills gaps in understanding of flowering plant
RT genome evolution.";
RL Nat. Plants 5:63-73(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-
CC ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-
CC formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide;
CC Xref=Rhea:RHEA:15053, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453,
CC ChEBI:CHEBI:143788, ChEBI:CHEBI:147286, ChEBI:CHEBI:195366;
CC EC=2.1.2.2; Evidence={ECO:0000256|ARBA:ARBA00036742};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-
CC formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-
CC ribosyl)glycinamide (10-formyl THF route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005054}.
CC -!- SIMILARITY: Belongs to the GART family.
CC {ECO:0000256|ARBA:ARBA00038440}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWR92108.1}.
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DR EMBL; QPKB01000009; RWR92108.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S4PLR2; -.
DR STRING; 337451.A0A3S4PLR2; -.
DR UniPathway; UPA00074; UER00126.
DR Proteomes; UP000283530; Unassembled WGS sequence.
DR GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd08645; FMT_core_GART; 2.
DR Gene3D; 3.40.50.170; Formyl transferase, N-terminal domain; 2.
DR HAMAP; MF_01930; PurN; 1.
DR InterPro; IPR002376; Formyl_transf_N.
DR InterPro; IPR036477; Formyl_transf_N_sf.
DR InterPro; IPR004607; GART.
DR InterPro; IPR001555; GART_AS.
DR PANTHER; PTHR43369; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; 1.
DR PANTHER; PTHR43369:SF2; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; 1.
DR Pfam; PF00551; Formyl_trans_N; 2.
DR SUPFAM; SSF53328; Formyltransferase; 2.
DR PROSITE; PS00373; GART; 2.
PE 3: Inferred from homology;
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000283530};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RWR92108.1}.
FT DOMAIN 81..257
FT /note="Formyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00551"
FT DOMAIN 258..433
FT /note="Formyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00551"
SQ SEQUENCE 449 AA; 48785 MW; 71ED53158CA446A2 CRC64;
MESSRLSINF SPNPSNRLPK LQSQTHLNFP SQKCFFCKTH LDLKIVLHRK VTQKAFQCKN
KAESGDFVAT GDDSGYGFRR KKLAAFVSGG GSNFRSIHEA TCRGRIHGDV AVVVTDKPGC
GGAEYAREEG IPVLLFPKTS TLNEGLSAVD LVSSLREFEI DFVLLAGFLK LIPVELVRAY
PKSILNIHPS LLPSFGGKGY YGLKVHKAVI ASGARYSGPT IHFVDEHYDT GRILAQRVVP
VLANDTAKEL AARVLHQLAA FVSGGGSNFR SIHEATCRGR IHGDVAVVVT DKPGCGGAEY
AREEGIPVLL FPKTSTLNEG LSAVDLVSSL REFEIDFVLL AGFLKLIPVE LVRAYPKSIL
NIHPSLLPSF GGKGYYGLKV HKAVIASGAR YSGPTIHFVD EHYDTGRILA QRVVPVLAND
TAKELAARVL HQDLKQGPGS RTFNNVKKC
//
