ID   A0A3S4RBW0_MYCCI        Unreviewed;       105 AA.
AC   A0A3S4RBW0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Small multidrug resistance protein {ECO:0000313|EMBL:VEG44690.1};
GN   Name=sugE {ECO:0000313|EMBL:VEG44690.1};
GN   ORFNames=NCTC10485_00253 {ECO:0000313|EMBL:VEG44690.1};
OS   Mycolicibacterium chitae (Mycobacterium chitae).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1792 {ECO:0000313|EMBL:VEG44690.1, ECO:0000313|Proteomes:UP000282551};
RN   [1] {ECO:0000313|EMBL:VEG44690.1, ECO:0000313|Proteomes:UP000282551}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10485 {ECO:0000313|EMBL:VEG44690.1,
RC   ECO:0000313|Proteomes:UP000282551};
RG   Pathogen Informatics;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003942};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003942}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr
CC       subfamily. {ECO:0000256|ARBA:ARBA00007822}.
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DR   EMBL; LR134355; VEG44690.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3S4RBW0; -.
DR   OrthoDB; 21828at2; -.
DR   Proteomes; UP000282551; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3730.20; -; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561:SF0; GUANIDINIUM EXPORTER; 1.
DR   PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282551};
KW   Transmembrane {ECO:0000256|RuleBase:RU003942, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   105 AA;  10632 MW;  23BA1364A9CC245C CRC64;
     MAWLILVVSA VFEAVWAVAL GKSEGFTRLG PSLVFAVGAV ISMGGLAIAM RDLPTGTSYA
     VWVGIGASLT VAYGMVTGSE VASIAKILLI LGIVGCVIGL KLVGH
//